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The solvation process of an alkali ion (Na$^+$, K$^+$, Rb$^+$, Cs$^+$) inside a superfluid $^4$He$_{2000}$ nanodroplet is investigated theoretically using liquid $^4$He time-dependent density functional theory at zero temperature. We…
Living organisms continuously harness energy to perform complex functions for their adaptation and survival while part of that energy is dissipated in the form of heat or chemical waste. Determining the energetic cost and the efficiency of…
Site-specific information on how adenosine triphosphate in the aqueous phase (ATP$_{(aq)}$) interacts with magnesium (Mg$^{2+}_{(aq)}$) is a prerequisite to understanding its complex biochemistry. To gather such information, we apply…
Cardiovascular disease affects millions of people worldwide and its social and economic cost clearly motivates scientific research. Computer simulation can lead to a better understanding of cardiac physiology, and for pathology presents…
Templated copying is the central operation by which biology produces complex molecules. Cells copy sequence information from DNA to RNA and on into proteins, which are the molecules responsible for the function and regulation of cellular…
We calculate the temperature-dependent elastic constants of palladium, platinum, copper and gold within the quasi-harmonic approximation using a first-principles approach and evaluating numerically the second derivatives of the Helmholtz…
The state-of-the-art cardiovascular disease diagnosis techniques use machine-learning algorithms based on feature extraction and classification. In this work, in contrast to a conventional single Electrocardiogram (ECG) lead, two leads are…
There have been suggestions that heat caused by cerebral metabolic activity may constrain mammalian brain evolution, architecture, and function. This article investigates physical limits on brain wiring and corresponding changes in brain…
Pulmonary hypertension (PH), defined by a mean pulmonary arterial pressure (mPAP) $>$ 20 mmHg, is characterized by increased pulmonary vascular resistance and decreased pulmonary arterial compliance. There are few measurable biomarkers of…
Amplitude equations are derived that describe the spatiotemporal dynamics of cardiac alternans during periodic pacing of one- and two-dimensional homogeneous tissue and one-dimensional anatomical reentry in a ring of homogeneous tissue.…
Among cardiovascular diseases, atherosclerosis is a primary cause of stenosis, involving the accumulation of plaques in the inner lining of an artery. Inspired by drug delivery applications, the proposed study aims to examine the numerical…
Two crucial factors for accurate numerical simulations of cardiac electromechanics, which are also essential to reproduce the synchronous activity of the heart, are: i) accounting for the interaction between the heart and the circulatory…
Understanding stabilization and aggregation in magnetic nanoparticle systems is crucial to optimizing the functionality of these systems in real physiological applications. Here we address this problem for a specific, yet representative,…
Phase diagrams serve as a highly informative tool for materials design, encapsulating information about the phases that a material can manifest under specific conditions. In this work, we develop a method in which Bayesian inference is…
The electrophysiology of betacells is at the origin of insulin secretion. Betacells exhibit a complex behaviour upon stimulation with glucose including repeated and uninterrupted bursting. Mathematical modelling is most suitable to improve…
It is shown that a model coupling the heat-conducting compressible Navier-Stokes equations to a micro-physics model of moisture in air is locally strongly well-posed for large data in suitable function spaces and strongly well-posed on…
Classification and prediction of heart disease is a significant problem to realize medical treatment and life protection. In this paper, persistent homology is involved to analyze electrocardiograms and a novel heart disease classification…
Extracellular matrix (ECM) remodeling is central to a wide variety of healthy and diseased tissue processes. Unfortunately, predicting ECM remodeling under various chemical and mechanical conditions has proven to be excessively challenging,…
The proposed system consists of a two-stage cascade. The first stage performs a rough heartbeat detection while the second stage refines the previous one, improving the temporal localization and also classifying the heartbeats into types S1…
Previous models of the cerebrovascular smooth muscle cell have not addressed the interaction between the electrical, chemical and mechanical components of cell function during the development of active tension. These models are primarily…