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Biological systems are often modelled at different levels of abstraction depending on the particular aims/resources of a study. Such different models often provide qualitatively concordant predictions over specific parametrisations, but it…

Machine Learning · Statistics 2016-05-10 Giulio Caravagna , Luca Bortolussi , Guido Sanguinetti

In the field of functional genomics, the analysis of gene expression profiles through Machine and Deep Learning is increasingly providing meaningful insight into a number of diseases. The paper proposes a novel algorithm to perform Feature…

Genomics · Quantitative Biology 2023-03-31 Carlo Adornetto , Gianluigi Greco

Use of computational methods to predict gene regulatory networks (GRNs) from gene expression data is a challenging task. Many studies have been conducted using unsupervised methods to fulfill the task; however, such methods usually yield…

Machine Learning · Computer Science 2016-08-15 Nihir Patel , Jason T. L. Wang

By leveraging GPT-4 for ontology narration, we developed GPTON to infuse structured knowledge into LLMs through verbalized ontology terms, achieving accurate text and ontology annotations for over 68% of gene sets in the top five…

Quantitative Methods · Quantitative Biology 2024-10-18 Rongbin Li , Wenbo Chen , Jinbo Li , Hanwen Xing , Hua Xu , Zhao Li , W. Jim Zheng

The innovation of next-generation sequencing (NGS) techniques has significantly reduced the price of genome sequencing, lowering barriers to future medical research; it is now feasible to apply genome sequencing to studies where it would…

Genomics · Quantitative Biology 2024-06-06 Arshmeet Kaur , Morteza Sarmadi

Most current work in NLP utilizes deep learning, which requires a lot of training data and computational power. This paper investigates the strengths of Genetic Algorithms (GAs) for extractive summarization, as we hypothesized that GAs…

Computation and Language · Computer Science 2022-01-11 William Chen , Kensal Ramos , Kalyan Naidu Mullaguri , Annie S. Wu

Interrogating the evolution of biological changes at early stages of life requires longitudinal profiling of molecules, such as DNA methylation, which can be challenging with children. We introduce a probabilistic and longitudinal machine…

Genomics · Quantitative Biology 2025-04-24 Arthur Leroy , Ai Ling Teh , Frank Dondelinger , Mauricio A. Alvarez , Dennis Wang

Given a sample of genome sequences from an asexual population, can one predict its evolutionary future? Here we demonstrate that the branching patterns of reconstructed genealogical trees contains information about the relative fitness of…

Populations and Evolution · Quantitative Biology 2014-11-13 Richard A. Neher , Colin A. Russell , Boris I. Shraiman

Generating molecules, both in a directed and undirected fashion, is a huge part of the drug discovery pipeline. Genetic algorithms (GAs) generate molecules by randomly modifying known molecules. In this paper we show that GAs are very…

Neural and Evolutionary Computing · Computer Science 2023-10-16 Austin Tripp , José Miguel Hernández-Lobato

Databases compiled using ab-initio and symmetry-based calculations now contain tens of thousands of topological insulators and topological semimetals. This makes the application of modern machine learning methods to topological materials…

Materials Science · Physics 2020-07-01 Nikolas Claussen , B. Andrei Bernevig , Nicolas Regnault

Learning multiple tasks sequentially without forgetting previous knowledge, called Continual Learning(CL), remains a long-standing challenge for neural networks. Most existing methods rely on additional network capacity or data replay. In…

Machine Learning · Computer Science 2022-02-01 Hao Liu , Huaping Liu

We report a deep generative model for regression tasks in materials informatics. The model is introduced as a component of a data imputer, and predicts more than 20 diverse experimental properties of organic molecules. The imputer is…

Computational Physics · Physics 2021-03-02 Kan Hatakeyama-Sato , Kenichi Oyaizu

This study is focused on applying genetic algorithms (GA) to model and band selection in hyperspectral image classification. We use a forensic-inspired data set of seven hyperspectral images with blood and five visually similar substances…

Computer Vision and Pattern Recognition · Computer Science 2020-11-05 Filip Pałka , Wojciech Książek , Paweł Pławiak , Michał Romaszewski , Kamil Książek

In this paper we demonstrate how genetic algorithms can be used to reverse engineer an evaluation function's parameters for computer chess. Our results show that using an appropriate mentor, we can evolve a program that is on par with top…

Neural and Evolutionary Computing · Computer Science 2017-11-21 Eli David , Moshe Koppel , Nathan S. Netanyahu

In this chapter we illustrate the use of some Machine Learning techniques in the context of omics data. More precisely, we review and evaluate the use of Random Forest and Penalized Multinomial Logistic Regression for integrative analysis…

Genomics · Quantitative Biology 2024-02-09 Aida Calviño , Almudena Moreno-Ribera , Silvia Pineda

In recent years, Machine Learning algorithms, in particular supervised learning techniques, have been shown to be very effective in solving regression problems. We compare the performance of a newly proposed regression algorithm against…

Machine Learning · Computer Science 2023-06-16 Sabina Gooljar , Kris Manohar , Patrick Hosein

Defect prediction models---classifiers that identify defect-prone software modules---have configurable parameters that control their characteristics (e.g., the number of trees in a random forest). Recent studies show that these classifiers…

Software Engineering · Computer Science 2018-02-01 Chakkrit Tantithamthavorn , Shane McIntosh , Ahmed E. Hassan , Kenichi Matsumoto

With this paper, we contribute to the growing research area of feature-based analysis of bio-inspired computing. In this research area, problem instances are classified according to different features of the underlying problem in terms of…

Neural and Evolutionary Computing · Computer Science 2016-02-10 Shayan Poursoltan , Frank Neumann

The integration of advanced technologies, such as Artificial Intelligence (AI), into manufacturing processes is attracting significant attention, paving the way for the development of intelligent systems that enhance efficiency and…

Neural and Evolutionary Computing · Computer Science 2025-12-09 Mohammadhossein Ghahramani , Yan Qiao , NaiQi Wu , Mengchu Zhou

We present a genetic algorithm framework for automatically discovering deep learning optimization algorithms. Our approach encodes optimizers as genomes that specify combinations of primitive update terms (gradient, momentum, RMS…

Neural and Evolutionary Computing · Computer Science 2025-12-16 Mitchell Marfinetz
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