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Molecular dynamics simulations are indispensable for exploring the behavior of atoms and molecules. Grounded in quantum mechanical principles, quantum molecular dynamics provides high predictive power but its computational cost is dominated…

Chemical Physics · Physics 2025-09-10 Siu Wun Cheung , Youngsoo Choi , Jean-Luc Fattebert , Daniel Osei-Kuffuor

This paper addresses the ``curse of dimensionality'' in the loss valuation of credit risk models. A dimension reduction methodology based on the Bayesian filter and smoother is proposed. This methodology is designed to achieve a fast and…

Computational Engineering, Finance, and Science · Computer Science 2024-01-02 Jian He , Asma Khedher , Peter Spreij

We introduce a density-based clustering method called skeleton clustering that can detect clusters in multivariate and even high-dimensional data with irregular shapes. To bypass the curse of dimensionality, we propose surrogate density…

Machine Learning · Statistics 2023-03-09 Zeyu Wei , Yen-Chi Chen

We propose a novel probabilistic dimensionality reduction framework that can naturally integrate the generative model and the locality information of data. Based on this framework, we present a new model, which is able to learn a smooth…

Machine Learning · Statistics 2016-10-18 Li Wang

In a world made of atoms, the computer simulation of molecular systems, such as proteins in water, plays an enormous role in science. Software packages that perform these computations have been developed for decades. In molecular…

Chemical Physics · Physics 2024-08-07 Philipp Hoellmer , A. C. Maggs , Werner Krauth

We consider dimensional reduction techniques for the Liouville-von Neumann equation for the evaluation of the expectation values in a mixed quantum system. In applications such as nuclear spin dynamics the main goal for simulations is being…

Numerical Analysis · Mathematics 2010-03-18 Giacomo Mazzi , Ben Leimkuhler

The scalability of statistical estimators is of increasing importance in modern applications. One approach to implementing scalable algorithms is to compress data into a low dimensional latent space using dimension reduction methods. In…

Machine Learning · Statistics 2015-04-14 Gregory Darnell , Stoyan Georgiev , Sayan Mukherjee , Barbara E Engelhardt

Reduced k-means clustering is a method for clustering objects in a low-dimensional subspace. The advantage of this method is that both clustering of objects and low-dimensional subspace reflecting the cluster structure are simultaneously…

Statistics Theory · Mathematics 2014-02-14 Yoshikazu Terada

A novel combination of two widely-used clustering algorithms is proposed here for the detection and reduction of high data density regions. The Density Based Spatial Clustering of Applications with Noise (DBSCAN) algorithm is used for the…

Computational Physics · Physics 2023-07-19 Bart J. J. Kremers , Aaron Ho , Jonathan Citrin , Karel L. van de Plassche

Dimensionality reduction is used as an important tool for unraveling the complexities of high-dimensional datasets in many fields of science, such as cell biology, chemical informatics, and physics. Visualizations of the dimensionally…

Human-Computer Interaction · Computer Science 2025-07-16 Dylan Cashman , Mark Keller , Hyeon Jeon , Bum Chul Kwon , Qianwen Wang

Data sets that are specified by a large number of features are currently outside the area of applicability for quantum machine learning algorithms. An immediate solution to this impasse is the application of dimensionality reduction methods…

Non-linear dimensionality reduction can be performed by \textit{manifold learning} approaches, such as Stochastic Neighbour Embedding (SNE), Locally Linear Embedding (LLE) and Isometric Feature Mapping (ISOMAP). These methods aim to produce…

Machine Learning · Statistics 2021-12-09 Theodoulos Rodosthenous , Vahid Shahrezaei , Marina Evangelou

We address the problem of communicating domain knowledge from a user to the designer of a clustering algorithm. We propose a protocol in which the user provides a clustering of a relatively small random sample of a data set. The algorithm…

Machine Learning · Statistics 2015-06-22 Hassan Ashtiani , Shai Ben-David

For large scale electronic structure calculation, the Krylov subspace method is introduced to calculate the one-body density matrix instead of the eigenstates of given Hamiltonian. This method provides an efficient way to extract the…

Materials Science · Physics 2009-11-10 Ryu Takayama , Takeo Hoshi , Takeo Fujiwara

Aluminum alloys are increasingly utilized as lightweight materials in the automobile industry due to their superior capability in withstanding high mechanical loads. A significant challenge impeding the large-scale use of these alloys in…

Computational Engineering, Finance, and Science · Computer Science 2022-03-31 Shiguang Deng , Carl Soderhjelm , Diran Apelian , Ramin Bostanabad

Molecular Dynamics (MD) simulations are fundamental computational tools for the study of proteins and their free energy landscapes. However, sampling protein conformational changes through MD simulations is challenging due to the relatively…

Biomolecules · Quantitative Biology 2023-07-20 Diego E. Kleiman , Hassan Nadeem , Diwakar Shukla

DNA storage technology offers new possibilities for addressing massive data storage due to its high storage density, long-term preservation, low maintenance cost, and compact size. To improve the reliability of stored information, base…

Machine Learning · Computer Science 2024-09-24 Bowen Liu , Jiankun Li

Dimension reduction algorithms are a crucial part of many data science pipelines, including data exploration, feature creation and selection, and denoising. Despite their wide utilization, many non-linear dimension reduction algorithms are…

Machine Learning · Statistics 2024-08-06 Ryan Murray , Adam Pickarski

In the field of gestural action recognition, many studies have focused on dimensionality reduction along the spatial axis, to reduce both the variability of gestural sequences expressed in the reduced space, and the computational complexity…

Machine Learning · Computer Science 2014-09-18 Pierre-François Marteau , Sylvie Gibet , Clement Reverdy

We describe a robust, fast, and memory-efficient procedure that can cluster millions of structures derived from molecular dynamics simulations. The essence of the method is based on a peak-picking algorithm applied to three- and…

Biomolecules · Quantitative Biology 2015-12-15 Athanasios S. Baltzis , Panagiotis I. Koukos , Nicholas M. Glykos
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