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We examine the use of time series data, derived from Electric Cell-substrate Impedance Sensing (ECIS), to differentiate between standard mammalian cell cultures and those infected with a mycoplasma organism. With the goal of interpretable…

Quantitative Methods · Quantitative Biology 2022-02-23 Laura L. Tupper , Charles R. Keese , David S. Matteson

Since 1984, electric cell-substrate impedance sensing (ECIS) has been used to monitor cell behavior in tissue culture and has proven sensitive to cell morphological changes and cell motility. We have taken ECIS measurements on several…

Cell Behavior · Quantitative Biology 2009-11-13 D. C. Lovelady , T. C. Richmond , A. N. Maggi , C. -M. Lo , D. A. Rabson

Measurements of many biological processes are characterized by an initial trend period followed by an equilibrium period. Scientists may wish to quantify features of the two periods, as well as the timing of the change point. Specifically,…

Applications · Statistics 2020-09-22 Wenyu Zhang , Maryclare Griffin , David S. Matteson

Oral cancer is a significant global health burden, and early detection remains a critical clinical need. Electrical impedance spectroscopy (EIS) offers a promising non-invasive approach for real-time tissue characterization, but…

Biological cells, by definition, are the basic units which contain the fundamental molecules of life of which all living things are composed. Understanding how they function and differentiating cells from one another therefore is of…

Signal Processing · Electrical Eng. & Systems 2021-01-07 Hassan Raji , Muhammad Tayyab , Jianye Sui , Seyed Reza Mahmoodi , Mehdi Javanmard

Cell detection is the task of detecting the approximate positions of cell centroids from microscopy images. Recently, convolutional neural network-based approaches have achieved promising performance. However, these methods require a…

Computer Vision and Pattern Recognition · Computer Science 2021-07-20 Kazuya Nishimura , Hyeonwoo Cho , Ryoma Bise

Electrochemical impedance spectroscopy (EIS) is an effective method for studying the electrochemical systems. The interpretation of EIS is the biggest challenge in this technology, which requires reasonable modeling. However, the modeling…

Data Analysis, Statistics and Probability · Physics 2019-07-04 Shan Zhu , Xinyang Sun , Yuxuan Wang , Naiqin Zhao , Junwei Sha

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) derived from somatic cells (SCs) provide promising resources for regenerative medicine and medical research, leading to a daily identification of new cell lines.…

Quantitative Methods · Quantitative Biology 2013-02-15 Anyou Wang

Impedance measurement is a common technique to characterize and detect the electrical properties of biological cells. However, to decode the underlying physical processes, it requires complex electrical models alongside prior knowledge of…

Instrumentation and Detectors · Physics 2020-12-02 Roberto G. Ramírez-Chavarría , Celia Sánchez-Pérez , Luisa Romero-Ornelas , Eva Ramón-Gallegos

Determining cell identities in imaging sequences is an important yet challenging task. The conventional method for cell identification is via cell tracking, which is complex and can be time-consuming. In this study, we propose an innovative…

Quantitative Methods · Quantitative Biology 2024-03-05 Baiyang Dai , Jiamin Yang , Hari Shroff , Patrick La Riviere

Power storage devices such as batteries are a crucial part of modern technology. The development and use of batteries has accelerated in the past decades, yet there are only a few techniques that allow gathering vital information from…

Cells are the fundamental unit of biological organization, and identifying them in imaging data - cell segmentation - is a critical task for various cellular imaging experiments. While deep learning methods have led to substantial progress…

We describe an impedance-based method for cell barrier integrity testing. A four-electrode electrical impedance spectroscopy (EIS) setup can be realized by simply connecting a commercial chopstick-like electrode (STX-1) to a potentiostat…

In this review, we aim to introduce the reader to the technique of electrical impedance spectroscopy (EIS) with a focus on its biological and medical applications. We explain the theoretical and experimental aspects of the EIS with the…

Electrochemical Impedance Spectroscopy (EIS) is a non-invasive technique widely used for understanding charge transfer and charge transport processes in electrochemical systems and devices. Standard approaches for the interpretation of EIS…

In multicellular organisms, cells coordinate their activities through cell-cell communication (CCC), which is crucial for development, tissue homeostasis, and disease progression. Recent advances in single-cell and spatial omics…

Quantitative Methods · Quantitative Biology 2026-03-24 Xiangzheng Cheng , Haili Huang , Ye Su , Qing Nie , Xiufen Zou , Suoqin Jin

Determining the trajectories of cells and their lineages or ancestries in live-cell experiments are fundamental to the understanding of how cells behave and divide. This paper proposes novel online algorithms for jointly tracking and…

Signal Processing · Electrical Eng. & Systems 2021-10-29 Tran Thien Dat Nguyen , Ba-Ngu Vo , Ba-Tuong Vo , Du Yong Kim , Yu Suk Choi

Potentiostatic impedance spectroscopy (IS) is a well stablished characterization technique for elucidating the electric resistivity and capacitive features of materials and devices. In the case of solar cells, by applying a small voltage…

Impedance Spectroscopy resolves electrical properties into uncorrelated variables, as a function of frequency, with exquisite resolution. Separation is robust and most useful when the system is linear. Impedance spectroscopy combined with…

Quantitative Methods · Quantitative Biology 2015-11-05 Robert Eisenberg

A rigorous methodology is proposed to study cell division data consisting in several observed genealogical trees of possibly different shapes. The procedure takes into account missing observations, data from different trees, as well as the…

Applications · Statistics 2013-04-15 Benoîte de Saporta , Anne Gégout Petit , Laurence Marsalle
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