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Endocytosis is an essential biological process for the trafficking of macromolecules (cargo) and membrane proteins in cells. In yeast cells, this involves the invagination of a tubular structure on the membrane and the formation of…

Soft Condensed Matter · Physics 2022-11-18 Ke Xiao , Chen-Xu Wu , Rui Ma

The surface free energy of ideal hard rods near curved hard surfaces is determined to second order in curvature for surfaces of general shape. In accordance with previous results for spherical and cylindrical surfaces it is found that this…

Soft Condensed Matter · Physics 2009-10-31 B. Groh

A very recent observation on the membrane mediated attraction and ordered aggregation of colloidal particles bound to giant phospholipid vesicles (I. Koltover, J. O. R\"{a}dler, C. R. Safinya, Phys. Rev. Lett. {\bf 82}, 1991(1999)) is…

Soft Condensed Matter · Physics 2009-10-31 Quan-Hui Liu , Ji-Xing Liu , Ou-Yang Zhong-Can

An anisotropic surface energy is the integral of an energy density that depends on the normal at each point over the considered surface, and it is a generalization of surface area. The minimizer of such an energy among all closed surfaces…

Differential Geometry · Mathematics 2019-03-20 Yoshiki Jikumaru , Miyuki Koiso

We apply the Bogomol'nyi technique, which is usually invoked in the study of solitons or models with topological invariants, to the case of elastic energy of vesicles. We show that spontaneous bending contribution caused by any deformation…

Soft Condensed Matter · Physics 2009-11-07 Jerome Benoit , Avadh Saxena , Turab Lookman

We study a variational problem for piecewise-smooth hypersurfaces in the (n+1)-dimensional Euclidean space with an anisotropic energy. An anisotropic energy is the integral of an energy density that depends on the normal at each point over…

Differential Geometry · Mathematics 2019-03-12 Miyuki Koiso

The energetically most efficient way how a deformed red blood cell regains equilibrium is mathematically described by the gradient flow of the Canham-Helfrich functional, including a spontaneous curvature and the conservation of surface…

Analysis of PDEs · Mathematics 2024-08-15 Fabian Rupp , Christian Scharrer , Manuel Schlierf

A cell membrane can be simply regarded as composite material consisting of lipid bilayer, membrane cytoskeleton beneath lipid bilayer, and proteins embedded in lipid bilayer and linked with membrane cytoskeleton if one only concerns its…

Other Quantitative Biology · Quantitative Biology 2007-06-26 Z. C. Tu , R. An , Z. C. Ou-Yang

We propose a numerical method for fluid deformable surfaces governed by surface Stokes flow and Helfrich bending energy under active growth, aiming to model shape evolution of the epithelium in developmental processes. To prevent…

Fluid Dynamics · Physics 2026-02-17 Maik Porrmann , Sören Bartels , Axel Voigt

Geometric continuum models for fluid lipid membranes are considered using classical field theory, within a covariant variational approach. The approach is cast as a higher-derivative Lagrangian formulation of continuum classical field…

Mathematical Physics · Physics 2017-09-14 Riccardo Capovilla

Motivated by a model for lipid bilayer cell membranes, we study the minimization of the Willmore functional in the class of oriented closed surfaces with prescribed total mean curvature, prescribed area, and prescribed genus. Adapting…

Differential Geometry · Mathematics 2024-03-22 Christian Scharrer , Alexander West

The electrostatic contribution to spontaneous membrane curvature is calculated within Poisson-Boltzmann theory under a variety of assumptions and emphasizing parameters in the physiological range. Asymmetric surface charges, either fixed…

Condensed Matter · Physics 2009-10-28 Tom Chou , Marko V. Jaric' , Eric D. Siggia

We prove a general Li-Yau inequality for the Helfrich functional where the spontaneous curvature enters with a singular volume type integral. In the physically relevant cases, this term can be converted into an explicit energy threshold…

Differential Geometry · Mathematics 2024-09-09 Fabian Rupp , Christian Scharrer

We derive and analyse an energy to model lipid raft formation on biological membranes involving a coupling between the local mean curvature and the local composition. We apply a perturbation method recently introduced by Fritz, Hobbs and…

Analysis of PDEs · Mathematics 2020-12-24 Charles M. Elliott , Luke Hatcher

Since the pioneering work of Canham and Helfrich, variational formulations involving curvature-dependent functionals, like the classical Willmore functional, have proven useful for shape analysis of biomembranes. We address minimizers of…

Analysis of PDEs · Mathematics 2012-07-24 Rustum Choksi , Marco Veneroni

Can the presence of molecular-tilt order significantly affect the shapes of lipid bilayer membranes, particularly membrane shapes with narrow necks? Motivated by the propensity for tilt order and the common occurrence of narrow necks in the…

Soft Condensed Matter · Physics 2009-11-13 Hongyuan Jiang , Greg Huber , Robert A. Pelcovits , Thomas R. Powers

Coarse-grained continuous descriptions for lipid bilayers are typically based on minimizing the Helfrich energy. Such models consider the fluid properties of these structures only implicitly and have been shown to nicely reproduce…

Soft Condensed Matter · Physics 2026-04-29 Ingo Nitschke , Jan Magnus Sischka , Axel Voigt

The Canham--Helfrich free-energy density for a lipid bilayer has drawn considerable attention. Aside from the mean and Gaussian curvatures, this free-energy density involves a spontaneous mean-curvature that encompasses information…

Biological Physics · Physics 2013-01-22 Brian Seguin , Eliot Fried

Hard spheres confined to narrow quasi-one-dimensional cylindrical channels form perfect helical structures at close packing. Here, we use molecular dynamics simulation to show that the thermodynamics, structure and dynamics of the fluid…

Soft Condensed Matter · Physics 2024-12-17 Mahdi Zarif , Richard K. Bowles

We consider nematic liquid crystals in a bounded, convex polyhedron described by a director field n(r) subject to tangent boundary conditions. We derive lower bounds for the one-constant elastic energy in terms of topological invariants.…

Mathematical Physics · Physics 2009-11-10 A Majumdar , JM Robbins , M Zyskin