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We propose a virtual staining methodology based on Generative Adversarial Networks to map histopathology images of breast cancer tissue from H&E stain to PHH3 and vice versa. We use the resulting synthetic images to build Convolutional…

Image and Video Processing · Electrical Eng. & Systems 2020-03-18 Caner Mercan , Germonda Reijnen-Mooij , David Tellez Martin , Johannes Lotz , Nick Weiss , Marcel van Gerven , Francesco Ciompi

Video style transfer is a useful component for applications such as augmented reality, non-photorealistic rendering, and interactive games. Many existing methods use optical flow to preserve the temporal smoothness of the synthesized video.…

Computer Vision and Pattern Recognition · Computer Science 2018-11-07 Wenbo Li , Longyin Wen , Xiao Bian , Siwei Lyu

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

Image style transfer aims to integrate the visual patterns of a specific artistic style into a content image while preserving its content structure. Existing methods mainly rely on the generative adversarial network (GAN) or stable…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Zhou Hong , Ning Dong , Yicheng Di , Xiaolong Xu , Rongsheng Hu , Yihua Shao , Run Ling , Yun Wang , Juqin Wang , Zhanjie Zhang , Ao Ma

Deep learning is popularly used for analyzing pathology images, but variations in image properties can limit the effectiveness of the models. The study aims to develop a method that transfers the variability present in the training set to…

Image and Video Processing · Electrical Eng. & Systems 2024-09-12 M. Muneeb Arshad , Hasan Sajid , M. Jawad Khan

The different stain styles of cytopathological images have a negative effect on the generalization ability of automated image analysis algorithms. This article proposes a new framework that normalizes the stain style for cytopathological…

Image and Video Processing · Electrical Eng. & Systems 2019-09-12 Xihao Chen , Jingya Yu , Li Chen , Shaoqun Zeng , Xiuli Liu , Shenghua Cheng

While pathology foundation models have transformed cancer image analysis, they often lack integration with molecular data at single-cell resolution, limiting their utility for precision oncology. Here, we present PAST, a pan-cancer…

Quantitative Methods · Quantitative Biology 2025-07-10 Changchun Yang , Haoyang Li , Yushuai Wu , Yilan Zhang , Yifeng Jiao , Yu Zhang , Rihan Huang , Yuan Cheng , Yuan Qi , Xin Guo , Xin Gao

Unpaired image-to-image translation using Generative Adversarial Networks (GAN) is successful in converting images among multiple domains. Moreover, recent studies have shown a way to diversify the outputs of the generator. However, since…

Computer Vision and Pattern Recognition · Computer Science 2021-07-15 Sho Inoue , Tad Gonsalves

Malignant melanoma is the deadliest form of skin cancer and, in recent years, is rapidly growing in terms of the incidence worldwide rate. The most effective approach to targeted treatment is early diagnosis. Deep learning algorithms,…

Image and Video Processing · Electrical Eng. & Systems 2020-09-21 Mario Manzo , Simone Pellino

Convolutional neural networks (CNNs) have been recently used for a variety of histology image analysis. However, availability of a large dataset is a major prerequisite for training a CNN which limits its use by the computational pathology…

Computer Vision and Pattern Recognition · Computer Science 2018-03-07 Ruqayya Awan , Navid Alemi Koohbanani , Muhammad Shaban , Anna Lisowska , Nasir Rajpoot

Histopathological images of tumors contain abundant information about how tumors grow and how they interact with their micro-environment. Better understanding of tissue phenotypes in these images could reveal novel determinants of…

Image and Video Processing · Electrical Eng. & Systems 2021-04-14 Adalberto Claudio Quiros , Roderick Murray-Smith , Ke Yuan

Unsupervised image-to-image translation has gained considerable attention due to the recent impressive progress based on generative adversarial networks (GANs). However, previous methods often fail in challenging cases, in particular, when…

Machine Learning · Computer Science 2019-01-03 Sangwoo Mo , Minsu Cho , Jinwoo Shin

While spatial transcriptomics (ST) has advanced our understanding of gene expression in tissue context, its high experimental cost limits its large-scale application. Predicting ST from pathology images is a promising, cost-effective…

Computer Vision and Pattern Recognition · Computer Science 2026-03-25 Zhiceng Shi , Changmiao Wang , Jun Wan , Wenwen Min

Gradient-based attention modeling has been used widely as a way to visualize and understand convolutional neural networks. However, exploiting these visual explanations during the training of generative adversarial networks (GANs) is an…

Computer Vision and Pattern Recognition · Computer Science 2021-08-18 Runze Li , Tomaso Fontanini , Luca Donati , Andrea Prati , Bir Bhanu

Computer assisted diagnosis in digital pathology is becoming ubiquitous as it can provide more efficient and objective healthcare diagnostics. Recent advances have shown that the convolutional Neural Network (CNN) architectures, a…

Image and Video Processing · Electrical Eng. & Systems 2022-01-05 Sruthi Krishna , Suganthi S. S , Shivsubramani Krishnamoorthy , Arnav Bhavsar

Transfer learning has emerged as a powerful methodology for adapting pre-trained deep neural networks on image recognition tasks to new domains. This process consists of taking a neural network pre-trained on a large feature-rich source…

Machine Learning · Computer Science 2021-04-27 Francisco Utrera , Evan Kravitz , N. Benjamin Erichson , Rajiv Khanna , Michael W. Mahoney

The works of Gatys et al. demonstrated the capability of Convolutional Neural Networks (CNNs) in creating artistic style images. This process of transferring content images in different styles is called Neural Style Transfer (NST). In this…

Computer Vision and Pattern Recognition · Computer Science 2024-11-13 Xiangtian Li , Han Cao , Zhaoyang Zhang , Jiacheng Hu , Yuhui Jin , Zihao Zhao

Image cartoonization is recently dominated by generative adversarial networks (GANs) from the perspective of unsupervised image-to-image translation, in which an inherent challenge is to precisely capture and sufficiently transfer…

Computer Vision and Pattern Recognition · Computer Science 2024-02-20 Xiang Gao , Yuqi Zhang , Yingjie Tian

There is a significant need for the generation of virtual histological information from coronary optical coherence tomography (OCT) images to better guide the treatment of coronary artery disease. However, existing methods either require a…

Image and Video Processing · Electrical Eng. & Systems 2023-07-25 Xueshen Li , Hongshan Liu , Xiaoyu Song , Brigitta C. Brott , Silvio H. Litovsky , Yu Gan

Style transfer aims to render the content of a given image in the graphical/artistic style of another image. The fundamental concept underlying NeuralStyle Transfer (NST) is to interpret style as a distribution in the feature space of a…

Computer Vision and Pattern Recognition · Computer Science 2021-03-15 Nikolai Kalischek , Jan Dirk Wegner , Konrad Schindler