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Lipid bilayer membranes are the fundamental biological barriers that permit life. The bilayer dynamics largely participates in orchestrating cellular workings and is characterized by substantial stability together with extreme plasticity…

Soft Condensed Matter · Physics 2022-12-05 Matteo Bottacchiari , Mirko Gallo , Marco Bussoletti , Carlo Massimo Casciola

Response of lipid bilayers to external mechanical stimuli is an active area of research with implications for fundamental and synthetic cell biology. However, there is a lack of tools for systematically imposing mechanical strains and…

Morphological change of bilayer membrane in vivo is not a spontaneous procedure but modulated by various types of proteins in general. Most of these modulations are associated with the localization of related proteins in the crowded lipid…

Quantitative Methods · Quantitative Biology 2016-06-30 Michael Mikucki , Y. C. Zhou

Modeling and direct numerical simulation of particle-laden flows have a tremendous variety of applications in science and engineering across a vast spectrum of scales from pollution dispersion in the atmosphere, to fluidization in the…

We present a novel thermodynamically guided, low-noise, time-scale bridging, and pertinently efficient strategy for the dynamic simulation of microscopic models for complex fluids. The systematic coarse-graining method is exemplified for…

Soft Condensed Matter · Physics 2010-11-12 Patrick Ilg , Hans Christian Öttinger , Martin Kröger

Computational modelling is helpful for elucidating the cellular mechanisms driving biological morphogenesis. Previous simulation studies of blood vessel growth based on the Cellular Potts model (CPM) proposed that elongated, adhesive or…

Cell Behavior · Quantitative Biology 2015-09-07 Dimitrios Palachanis , András Szabó , Roeland M. H. Merks

A molecular model is proposed of a bilayer consisting of fully saturated DPPC and mono unsaturated DOPC. The model not only encompasses the constant density within the hydrophobic core of the bilayer, but also the tendency of chain segments…

Biological Physics · Physics 2009-11-10 R. Elliott , K. Katsov , M. Schick , I. Szleifer

Cellular membranes exhibit a large variety of shapes, strongly coupled to their function. Many biological processes involve dynamic reshaping of membranes, usually mediated by proteins. This interaction works both ways: while proteins…

Soft Condensed Matter · Physics 2018-06-12 Afshin Vahid , Anđela Šarić , Timon Idema

Bilayer lipid membranes (BLMs) are an essential component of many biological systems, forming a functional barrier between the cell and the surrounding environment. When the membrane relaxes from a structural perturbation, the dynamics of…

Soft Condensed Matter · Physics 2015-07-27 R. J. Bingham , S. W. Smye , P. D. Olmsted

Obtaining a rigorous and reliable method for linking computer simulations of polymer blends and composites at different length scales of interest is a highly desirable goal in soft matter physics. In this paper a multiscale modeling…

Soft Condensed Matter · Physics 2015-05-19 J. McCarty , M. G. Guenza

Torques on interfaces can be described by a divergence-free tensor which is fully encoded in the geometry. This tensor consists of two terms, one originating in the couple of the stress, the other capturing an intrinsic contribution due to…

Soft Condensed Matter · Physics 2011-11-09 Martin Michael Mueller , Markus Deserno , Jemal Guven

We present a simple and efficient method to simulate three-dimensional, complex-shaped, interacting bodies. The particle shape is represented by Minkowski operators. A time-continuous interaction between these bodies is derived using simple…

Materials Science · Physics 2008-11-20 Sergio-Andres Galindo-Torres , Fernando Alonso-Marroquin , Yucang Wang

Understanding the on-chip motion of magnetic particles in a microfluidic environment is key to realizing magnetic particle-based Lab-on-a-chip systems for medical diagnostics. In this work, a simulation model is established to quantify the…

Three coarse-grained molecular dynamics (MD) models are investigated with the aim of developing and analyzing multiscale methods which use MD simulations in parts of the computational domain and (less detailed) Brownian dynamics (BD)…

Computational Physics · Physics 2015-06-18 Radek Erban

Lipid membranes form the barrier between the inside and outside of cells and many of their subcompartments. As such, they bind to a wide variety of nano- and micrometer sized objects and, in the presence of strong adhesive forces, strongly…

Soft Condensed Matter · Physics 2021-08-31 Hendrik T. Spanke , Jaime Agudo-Canalejo , Daniel Tran , Robert W. Style , Eric R. Dufresne

A hybrid mesoscopic multi-particle collision model is used to study diffusion-influenced reaction kinetics. The mesoscopic particle dynamics conserves mass, momentum and energy so that hydrodynamic effects are fully taken into account.…

Chemical Physics · Physics 2007-05-23 Kay Tucci , Raymond Kapral

While dissipation in collisional plasma is defined in terms of viscosity and resistivity, the exact functional form of dissipation i.e., the so-called dissipation function in nearly collisionless plasma is unknown. Nevertheless, previous…

Blebs are balloon-shaped membrane protrusions that form during many physiological processes. Using computer simulation of a particle-based model for self-assembled lipid bilayers coupled to an elastic meshwork, we investigated the phase…

Biological Physics · Physics 2015-05-30 Eric J. Spangler , Cameron W. Harvey , Joel D. Revalee , P. B. Sunil Kumar , Mohamed Laradji

Nonlinear interaction of a low density electron beam with a uniform plasma is studied using two-dimensional particle-in-cell (PIC) simulations. We focus on formation of coherent phase space structures in the case, when a wide…

Plasma Physics · Physics 2012-05-21 I. V. Timofeev

We formulate a simple effective model to describe molecular interactions in a lipid monolayer. The model represents lipid molecules in terms of two-dimensional anisotropic particles on the plane of the monolayer. These particles interact…

Soft Condensed Matter · Physics 2019-10-02 E. Velasco , L. Mederos