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Imaging-derived phenotypes (IDPs) summarize multi-organ physiology but provide only static snapshots of diseases that evolve over time. In contrast, longitudinal electronic health records encode disease trajectories through temporal…

Information Retrieval · Computer Science 2026-05-13 Zian Wang , Lizhen Lan , Guangming Wang , Haosen Zhang , Minxuan Xu , Qing Li , Tianxing He , Mo Yang , Wenyue Mao , Yajing Zhang , Yan Li , Chengyan Wang

In multiple correspondence analysis, both individuals (observations) and categories can be represented in a biplot that jointly depicts the relationships across categories or individuals, as well as the associations between them. Additional…

Methodology · Statistics 2019-01-10 Mariko Takagishi , Michel van de Velden

Effective information analysis generally boils down to properly identifying the structure or geometry of the data, which is often represented by a graph. In some applications, this structure may be partly determined by design constraints or…

Machine Learning · Computer Science 2016-11-07 Dorina Thanou , Xiaowen Dong , Daniel Kressner , Pascal Frossard

International initiatives such as METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) have collected several multigenomic and clinical data sets to identify the undergoing molecular processes taking place throughout the…

Machine Learning · Computer Science 2022-11-29 Teodora Reu

Many processes, from gene interaction in biology to computer networks to social media, can be modeled more precisely as temporal hypergraphs than by regular graphs. This is because hypergraphs generalize graphs by extending edges to connect…

Human-Computer Interaction · Computer Science 2021-05-12 Maximilian T. Fischer , Devanshu Arya , Dirk Streeb , Daniel Seebacher , Daniel A. Keim , Marcel Worring

Time series visualization plays a crucial role in identifying patterns and extracting insights across various domains. However, as datasets continue to grow in size, visualizing them effectively becomes challenging. Downsampling, which…

Human-Computer Interaction · Computer Science 2023-04-04 Jonas Van Der Donckt , Jeroen Van Der Donckt , Michael Rademaker , Sofie Van Hoecke

Background: Cancers are highly heterogeneous with different subtypes. These subtypes often possess different genetic variants, present different pathological phenotypes, and most importantly, show various clinical outcomes such as varied…

Graphics · Computer Science 2014-07-09 Hao Ding , Chao Wang , Kun Huang , Raghu Machiraju

We describe SynGraphy, a method for visually summarising the structure of large network datasets that works by drawing smaller graphs generated to have similar structural properties to the input graphs. Visualising complex networks is…

Social and Information Networks · Computer Science 2023-02-16 Jérôme Kunegis , Pawan Kumar , Jun Sun , Anna Samoilenko , Giuseppe Pirró

Stacking (or stacked generalization) is an ensemble learning method with one main distinctiveness from the rest: even though several base models are trained on the original data set, their predictions are further used as input data for one…

Machine Learning · Computer Science 2024-04-19 Ilya Ploshchik , Angelos Chatzimparmpas , Andreas Kerren

In the process of developing an infrastructure for providing visualization and visual analytics (VIS) tools to epidemiologists and modeling scientists, we encountered a technical challenge for applying a number of visual designs to numerous…

Human-Computer Interaction · Computer Science 2021-07-20 Saiful Khan , Phong H. Nguyen , Alfie Abdul-Rahman , Benjamin Bach , Min Chen , Euan Freeman , Cagatay Turkay

Vascular calcification is implicated as an important factor in major adverse cardiovascular events (MACE), including heart attack and stroke. A controversy remains over how to integrate the diverse forms of vascular calcification into…

Computer Vision and Pattern Recognition · Computer Science 2024-01-18 Mehdi Ramezanpour , Anne M. Robertson , Yasutaka Tobe , Xiaowei Jia , Juan R. Cebral

We present a path-based design model and system for designing and creating visualisations. Our model represents a systematic approach to constructing visual representations of data or concepts following a predefined sequence of steps. The…

Human-Computer Interaction · Computer Science 2024-08-08 James Jackson , Panagiotis D. Ritsos , Peter W. S. Butcher , Jonathan C. Roberts

When it comes to clinical survival trials, regulatory restrictions usually require the application of methods that solely utilize baseline covariates and the intention-to-treat principle. Thereby a lot of potentially useful information is…

Recent advances in single cell sequencing and multi-omics techniques have significantly improved our understanding of biological phenomena and our capacity to model them. Despite combined capture of data modalities showing similar progress,…

Molecular Networks · Quantitative Biology 2025-03-13 Marcello Barylli , Joyaditya Saha , Tineke E. Buffart , Jan Koster , Kristiaan J. Lenos , Louis Vermeulen , Vivek M. Sheraton

The emergence of computational fluid dynamics (CFD) enabled the simulation of intricate transport processes, including flow in physiological structures, such as blood vessels. While these so-called hemodynamic simulations offer…

The chemical sciences are producing an unprecedented amount of large, high-dimensional data sets containing chemical structures and associated properties. However, there are currently no algorithms to visualize such data while preserving…

Human-Computer Interaction · Computer Science 2020-01-07 Daniel Probst , Jean-Louis Reymond

Many rare genetic diseases exhibit recognizable facial phenotypes, which are often used as diagnostic clues. However, current facial phenotype diagnostic models, which are trained on image datasets, have high accuracy but often suffer from…

Quantitative Methods · Quantitative Biology 2025-04-21 Jie Song , Mengqiao He , Shumin Ren , Bairong Shen

Interpreting a nonparametric regression model with many predictors is known to be a challenging problem. There has been renewed interest in this topic due to the extensive use of machine learning algorithms and the difficulty in…

Machine Learning · Statistics 2018-09-11 Xiaoyu Liu , Jie Chen , Joel Vaughan , Vijayan Nair , Agus Sudjianto

Machine learning (ML) algorithms and machine learning based software systems implicitly or explicitly involve complex flow of information between various entities such as training data, feature space, validation set and results.…

Machine Learning · Computer Science 2019-08-05 Abon Chaudhuri

The association of a given human phenotype to a genetic variant remains a critical challenge for biology. We present a novel system called PhenoLinker capable of associating a score to a phenotype-gene relationship by using heterogeneous…