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Molecular profiling data (e.g., gene expression) has been used for clinical risk prediction and biomarker discovery. However, it is necessary to integrate other prior knowledge like biological pathways or gene interaction networks to…

Genomics · Quantitative Biology 2016-09-22 Wenwen Min , Juan Liu , Shihua Zhang

Re-randomization has gained popularity as a tool for experiment-based causal inference due to its superior covariate balance and statistical efficiency compared to classic randomized experiments. However, the basic re-randomization method,…

Methodology · Statistics 2023-09-20 Zhaoyang Liu , Tingxuan Han , Donald B. Rubin , Ke Deng

In this review, we assess the use of Bayesian methods in model predictive control (MPC), focusing on neural-network-based modeling, control design, and uncertainty quantification. We systematically analyze individual studies and how they…

Artificial Intelligence · Computer Science 2025-10-08 Asli Karacelik

Gaussian process regression has proven very powerful in statistics, machine learning and inverse problems. A crucial aspect of the success of this methodology, in a wide range of applications to complex and real-world problems, is…

Statistics Theory · Mathematics 2021-03-18 Yifan Chen , Houman Owhadi , Andrew M. Stuart

We introduce a flexible empirical Bayes approach for fitting Bayesian generalized linear models. Specifically, we adopt a novel mean-field variational inference (VI) method and the prior is estimated within the VI algorithm, making the…

Machine Learning · Statistics 2026-01-30 Dongyue Xie , Wanrong Zhu , Matthew Stephens

In high-dimensional and/or non-parametric regression problems, regularization (or penalization) is used to control model complexity and induce desired structure. Each penalty has a weight parameter that indicates how strongly the structure…

Machine Learning · Statistics 2017-03-30 Jean Feng , Noah Simon

External controls from historical trials or observational data can augment randomized controlled trials when large-scale randomization is impractical or unethical, such as in drug evaluation for rare diseases. However, non-randomized…

Methodology · Statistics 2025-05-08 Ke Zhu , Shu Yang , Xiaofei Wang

As an alternative to variable selection or shrinkage in high dimensional regression, we propose to randomly compress the predictors prior to analysis. This dramatically reduces storage and computational bottlenecks, performing well when the…

Machine Learning · Statistics 2013-03-26 Rajarshi Guhaniyogi , David B. Dunson

We study model evaluation and model selection from the perspective of generalization ability (GA): the ability of a model to predict outcomes in new samples from the same population. We believe that GA is one way formally to address…

Machine Learning · Statistics 2016-10-19 Ning Xu , Jian Hong , Timothy C. G. Fisher

This paper presents a novel nonlinear regression model for estimating heterogeneous treatment effects from observational data, geared specifically towards situations with small effect sizes, heterogeneous effects, and strong confounding.…

Methodology · Statistics 2019-11-14 P. Richard Hahn , Jared S. Murray , Carlos Carvalho

The synthetic control method has become a widely popular tool to estimate causal effects with observational data. Despite this, inference for synthetic control methods remains challenging. Often, inferential results rely on linear factor…

Methodology · Statistics 2024-07-09 Ignacio Martinez , Jaume Vives-i-Bastida

Models are often misspecified in practice, making model criticism a key part of Bayesian analysis. It is important to detect not only when a model is wrong, but which aspects are wrong, and to do so in a computationally convenient and…

Methodology · Statistics 2025-04-15 Christian T. Covington , Jeffrey W. Miller

Unbiased estimators are introduced for averaged Bregman divergences which generalize Stein's Unbiased (Predictive) Risk Estimator, and the minimization of these estimators is proposed as a regularization parameter selection method for…

Numerical Analysis · Mathematics 2021-11-22 Elias S. Helou , Sandra A. Santos , Lucas E. A. Simões

In inverse problems, it is widely recognized that the incorporation of a sparsity prior yields a regularization effect on the solution. This approach is grounded on the a priori assumption that the unknown can be appropriately represented…

Machine Learning · Statistics 2025-06-13 Giovanni S. Alberti , Luca Ratti , Matteo Santacesaria , Silvia Sciutto

Previous research on PAC-Bayes learning theory has focused extensively on establishing tight upper bounds for test errors. A recently proposed training procedure called PAC-Bayes training, updates the model toward minimizing these bounds.…

Machine Learning · Statistics 2024-10-22 Xitong Zhang , Avrajit Ghosh , Guangliang Liu , Rongrong Wang

The use of L1 regularisation for sparse learning has generated immense research interest, with successful application in such diverse areas as signal acquisition, image coding, genomics and collaborative filtering. While existing work…

Machine Learning · Computer Science 2012-08-20 Shakir Mohamed , Katherine Heller , Zoubin Ghahramani

We consider the so-called unfolding problem in experimental high energy physics, where the goal is to estimate the true spectrum of elementary particles given observations distorted by measurement error due to the limited resolution of a…

Applications · Statistics 2014-02-03 Mikael Kuusela , Victor M. Panaretos

Crossing of fitted conditional quantiles is a prevalent problem for quantile regression models. We propose a new Bayesian modelling framework that penalises multiple quantile regression functions toward the desired non-crossing space. We…

Methodology · Statistics 2025-08-21 David Kohns , Tibor Szendrei

Empirical Bayes inference is based on estimation of the parameters of an a priori distribution from the observed data. The estimation technique of the parameters of the prior, called hyperparameters, is based on the marginal distribution…

Systems and Control · Electrical Eng. & Systems 2025-11-06 Timofei Leahu , Giorgio Picci

Randomized experiments are the gold standard for evaluating the effects of changes to real-world systems. Data in these tests may be difficult to collect and outcomes may have high variance, resulting in potentially large measurement error.…

Machine Learning · Statistics 2018-06-27 Benjamin Letham , Brian Karrer , Guilherme Ottoni , Eytan Bakshy
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