Related papers: Patent Citation Spectroscopy (PCS): Algorithmic re…
We apply Patent Citation Spectroscopy (PCS)--originally developed as Reference Publication Year Spectroscopy for studying landmarks and milestones in scientific literature--to patent literature classified into the nine Y-subclasses of the…
Scientific activity plays a major role in innovation for biomedicine and healthcare. For instance, fundamental research on disease pathologies and mechanisms can generate potential targets for drug therapy. This co-evolution is punctuated…
Liquid chromatography with tandem mass spectrometry (LC-MS/MS) based proteomics is a well-established research field with major applications such as identification of disease biomarkers, drug discovery, drug design and development. In…
One of the most challenging problems in technological forecasting is to identify as early as possible those technologies that have the potential to lead to radical changes in our society. In this paper, we use the US patent citation network…
Given a patent document, identifying distinct semantic annotations is an interesting research aspect. Text annotation helps the patent practitioners such as examiners and patent attorneys to quickly identify the key arguments of any…
Essential protein plays a crucial role in the process of cell life. The identification of essential proteins can not only promote the development of drug target technology, but also contribute to the mechanism of biological evolution. There…
Patent retrieval underpins critical decisions in innovation, examination, and IP strategy, yet progress has been hampered by the absence of benchmarks that reflect the diversity of real world search scenarios. We address this gap with two…
Parkinson's disease (PD) is a progressive neurodegenerative disorder that lacks reliable early-stage biomarkers for diagnosis, prognosis, and therapeutic monitoring. While cerebrospinal fluid (CSF) biomarkers, such as alpha-synuclein seed…
In the realm of patent document analysis, assessing semantic similarity between phrases presents a significant challenge, notably amplifying the inherent complexities of Cooperative Patent Classification (CPC) research. Firstly, this study…
Pharmaceutical patents play an important role by protecting the innovation from copies but also drive researchers to innovate, create new products, and promote disruptive innovations focusing on collective health. The study of patent…
The Cooperative Patent Classifications (CPC) jointly developed by the European and US Patent Offices provide a new basis for mapping and portfolio analysis. This update provides an occasion for rethinking the parameter choices. The new maps…
Mass spectrometry provides a high-throughput approach to identify proteins in biological samples. A key step in the analysis of mass spectrometry data is to identify the peptide sequence that, most probably, gave rise to each observed…
Despite the usefulness of machine learning approaches for the early screening of potential breakthrough technologies, their practicality is often hindered by opaque models. To address this, we propose an interpretable machine learning…
The ultimate target of proteomics identification is to identify and quantify the protein in the organism. Mass spectrometry (MS) based on label-free protein quantitation has mainly focused on analysis of peptide spectral counts and ion peak…
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) derived from somatic cells (SCs) provide promising resources for regenerative medicine and medical research, leading to a daily identification of new cell lines.…
We consider the problem of testing the significance of features in high-dimensional settings. In particular, we test for differentially-expressed genes in a microarray experiment. We wish to identify genes that are associated with some type…
The network of patents connected by citations is an evolving graph, which provides a representation of the innovation process. A patent citing another implies that the cited patent reflects a piece of previously existing knowledge that the…
Motivation: Assigning statistical significance accurately has become increasingly important as meta data of many types, often assembled in hierarchies, are constructed and combined for further biological analyses. Statistical inaccuracy of…
The performance of medical research can be viewed and evaluated not only from the perspective of publication output, but also from the perspective of economic exploitability. Patents can represent the exploitation of research results and…
The ability to characterize proteins at sequence-level resolution is vital to biological research. Currently, the leading method for protein sequencing is by liquid chromatography mass spectrometry (LC-MS) whereas proteins are reduced to…