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A generalized understanding of protein dynamics is an unsolved scientific problem, the solution of which is critical to the interpretation of the structure-function relationships that govern essential biological processes. Here, we approach…

We critically discuss and review the general ideas behind single- and multi-site coarse-grained (CG) models as applied to macromolecular solutions in the dilute and semi-dilute regime. We first consider single-site models with zero-density…

Soft Condensed Matter · Physics 2015-10-28 Giuseppe D'Adamo , Roberto Menichetti , Andrea Pelissetto , Carlo Pierleoni

A general scheme, which includes constructions of coarse-grained (CG) models, weighted ensemble dynamics (WED) simulations and cluster analyses (CA) of stable states, is presented to detect dynamical and thermodynamical properties in…

Soft Condensed Matter · Physics 2008-12-04 Xin Zhou

A coarse-grained water model is developed using multistate iterative Boltzmann inversion. Following previous work, the k-means algorithm is used to dynamically map multiple water molecules to a single coarse-grained bead, allowing the use…

Chemical Physics · Physics 2015-09-29 Timothy C. Moore , Christopher R. Iacovella , Clare McCabe

Condense phase molecular systems organize in wide range of distinct molecular configurations, including amorphous melt and glass as well as crystals often exhibiting polymorphism, that originate from their intricate intra- and…

Mesoscale and Nanoscale Physics · Physics 2024-03-25 Brian H. Lee , James P. Larentzos , John K. Brennan , Alejandro Strachan

Coarse-grained (CG) models are often parametrized to reproduce one-dimensional structural correlation functions of an atomically-detailed model along the degrees of freedom governing each interaction potential. While cross correlations…

Soft Condensed Matter · Physics 2019-12-02 Svenja J. Woerner , Tristan Bereau , Kurt Kremer , Joseph F. Rudzinski

Fast and efficient 3D reconstruction is essential for time-critical robotic applications such as tele-guidance and disaster response, where operators must rapidly analyze specific points of interest (POIs). Existing semantic Gaussian…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Hannah Schieber , Dominik Frischmann , Victor Schaack , Simon Boche , Angela Schoellig , Stefan Leutenegger , Daniel Roth

We introduce an RG-inspired coarse-graining for extracting the collective features of data. The key to successful coarse-graining lies in finding appropriate pairs of data sets. We coarse-grain the two closest data in a regular real-space…

Data Analysis, Statistics and Probability · Physics 2023-07-19 Jonathan Landy , Tsvi Tlusty , YeongKyu Lee , YongSeok Jho

We develop coarse-grained particle approaches for studying the elastic mechanics of vesicles with heterogeneous membranes having phase-separated domains. We perform simulations both of passive shape fluctuations and of active systems where…

Soft Condensed Matter · Physics 2023-02-28 David A. Rower , Paul J. Atzberger

In this report we introduce the basic techniques (of the Closed Time Path - Coarse Grained Effective Action CTP-CGEA) and ideas (scaling, coarse-graining and backreaction) behind the treatment of quantum processes in dynamical background…

High Energy Physics - Theory · Physics 2008-11-26 Esteban A. Calzetta , Bei Lok Hu , Francisco D. Mazzitelli

We propose the coarse-grained spectral projection method (CGSP), a deep learning-assisted approach for tackling quantum unitary dynamic problems with an emphasis on quench dynamics. We show CGSP can extract spectral components of many-body…

Quantum Physics · Physics 2021-02-03 Pinchen Xie , Weinan E

I briefly review some concepts related to coarse-graining methods for the dynamics of soft matter systems and argue that such schemes will almost always need to telescope down the physical hierarchy of time-scales to a more compressed, but…

Soft Condensed Matter · Physics 2010-01-11 Ard A. Louis

This work explores the manner in which classical phase space distribution functions converge to the microcanonical distribution. We first prove a theorem about the lack of convergence, then define a generalization of the coarse-graining…

Statistical Mechanics · Physics 2024-08-26 Casey O. Barkan

We present an extension to the iterative Boltzmann inversion method to generate coarse-grained models with three-body intramolecular potentials that can reproduce correlations in structural distribution functions. The coarse-grained…

Computational Physics · Physics 2023-11-27 Jianlan Ye , Vipin Agrawal , Minghao Liu , Jing Hu , Jay Oswald

Using the probabilistic language of conditional expectations we reformulate the force matching method for coarse-graining of molecular systems as a projection on spaces of coarse observables. A practical outcome of this probabilistic…

Numerical Analysis · Mathematics 2015-04-10 Evangelia Kalligiannaki , Vagelis Harmandaris , Markos A. Katsoulakis , Petr Plechac

This series of papers has two broader aims: 1) Construct a theory for multi-partite open quantum systems comprising several layers of structure with self-consistent back-actions. Develop the graded influence action formalism…

High Energy Physics - Theory · Physics 2025-05-27 Jen-Tsung Hsiang , Bei-Lok Hu

Predicting the molecular friction and energy landscapes under nonequilibrium conditions is key to coarse-graining the dynamics of selective solute transport through complex, fluctuating and responsive media, e.g., polymeric materials such…

Soft Condensed Matter · Physics 2025-07-03 Sebastian Milster , Joachim Dzubiella , Gerhard Stock , Steffen Wolf

Density (or state) dependent pair potentials arise naturally from coarse-graining procedures in many areas of condensed matter science. However, correctly using them to calculate physical properties of interest is subtle and cannot be…

Soft Condensed Matter · Physics 2007-05-23 A. A. Louis

To study materials phenomena simultaneously at various length scales, descriptions in which matter can be coarse grained to arbitrary levels, are necessary. Attempts to do this in the static regime (i.e. zero temperature) have already been…

Materials Science · Physics 2009-11-07 Stefano Curtarolo , Gerbrand Ceder

We review some recent coarse-graining and multi-scale methods, but also put forward some new ideas for addressing such issues. We find that, if one is guided by nonequilibrium statistical mechanics and thermodynamics, it is possible to…

Soft Condensed Matter · Physics 2009-11-06 Patrick Ilg , Vlasis Mavrantzas , Hans Christian Öttinger