Related papers: Robustness of clocks to input noise
Time remains one of the least well understood concepts in physics, most notably in quantum mechanics. A central goal is to find the fundamental limits of measuring time. One of the main obstacles is the fact that time is not an observable…
Biological rhythms are generated by pacemaker organs, such as the heart pacemaker organ (the sinoatrial node) and the master clock of the circadian rhythms (the suprachiasmatic nucleus), which are composed of a network of autonomously…
From a thermodynamic point of view, all clocks are driven by irreversible processes. Additionally, one can use oscillatory systems to temporally modulate the thermodynamic flux towards equilibrium. Focusing on the most elementary…
Basic for the definition of 'time' are clocks operating under stationary conditions. The periods of two clocks can be compared with each other via two return experiments. The central clock mediates between the rotating and the inertial…
We develop a framework for the general interpretation of the stochastic dynamical system near a limit cycle. Such quasi-periodic dynamics are commonly found in a variety of nonequilibrium systems, including the spontaneous oscillations of…
Circadian clocks ubiquitous in life forms ranging bacteria to multi-cellular organisms, often exhibit intrinsic temperature compensation; the period of circadian oscillators is maintained constant over a range of physiological temperatures,…
Periodic forcing of nonlinear oscillators leads to a large number of dynamic behaviors. The coupling of the cell-cycle to the circadian clock provides a biological realization of such forcing. Using high throughput single-cell microscopy,…
We study the impact of light on the mammalian circadian system using the theory of phase response curves. Using a recently developed ansatz we derive a low-dimensional macroscopic model for the core circadian clock in mammals.…
We introduce the time glass, a non-periodic analogue of the discrete time crystal that arises in periodically driven dissipative quantum many-body systems. This phase is defined by two key features: (i) spatial long-range order arising from…
The suprachiasmatic nucleus (SCN), also known as the circadian master clock, consists of a large population of oscillator neurons. Together, these neurons produce a coherent signal that drives the body's circadian rhythms. What properties…
There is evidence that biological systems, such as the brain, work at a critical regime robust to noise, and are therefore able to remain in it under perturbations. In this work, we address the question of robustness of critical systems to…
Circadian (~24hr) clocks are self-sustained endogenous oscillators with which organisms keep track of daily and seasonal time. Circadian clocks frequently rely on interlocked transcriptional- translational feedback loops to generate rhythms…
The KaiABC circadian clock from cyanobacteria is the only known three-protein oscillatory system which can be reconstituted outside the cell and which displays sustained periodic dynamics in various molecular state variables. Despite many…
Almost all organisms show some kind of time periodicity in their behavior. Especially in mammals the neurons of the suprachiasmatic nucleus form a biological clock regulating the activity-inactivity cycle of the animal. This clock is…
Nearly all circadian clocks maintain a period that is insensitive to temperature changes, a phenomenon known as temperature compensation (TC). Yet, it is unclear whether there is any common feature among different systems that exhibit TC.…
For noisy self-sustained oscillators, both reliability, stability of a response to a noisy driving, and coherence understood in the sense of constancy of oscillation frequency belong to the main characteristics. Though the both…
Continuous clocks, i.e. the clocks that measure time in a continuous manner, are regarded as an essential component of sensing technology. Precision and recurrence time are two basic features of continuous clocks. In this paper, in the…
A van der Pol self sustained oscillator with higher order nonlinearity exhibits a rich dynamics, with multiple periodic attractors, and still the model allows analytical approximations. Some of these properties can be conveniently exploited…
Complex dynamical systems may exhibit multiple steady states, including time-periodic limit cycles, where the final trajectory depends on initial conditions. With tuning of parameters, limit cycles can proliferate or merge at an exceptional…
Shared upstream dynamical processes are frequently the source of common inputs in various physical and biological systems. However, due to finite signal transmission speeds and differences in the distance to the source, time shifts between…