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In this paper we study the inverse problem of identifying the diffusion matrix in an elliptic PDE from measurements. The convex energy functional method with Tikhonov regularization is applied to tackle this problem. For the discretization…

Numerical Analysis · Mathematics 2017-09-15 Michael Hinze , Tran Nhan Tam Quyen

Photoacoustic tomography (PAT) is a rapidly-evolving medical imaging modality that combines optical absorption contrast with ultrasound imaging depth. One challenge in PAT is image reconstruction with inadequate acoustic signals due to…

Recent advancements in text-guided diffusion models have unlocked powerful image manipulation capabilities. However, applying these methods to real images necessitates the inversion of the images into the domain of the pretrained diffusion…

Computer Vision and Pattern Recognition · Computer Science 2024-03-22 Daniel Garibi , Or Patashnik , Andrey Voynov , Hadar Averbuch-Elor , Daniel Cohen-Or

We present a numerical scheme for solving a parameter estimation problem for a model of low-grade glioma growth. Our goal is to estimate the spatial distribution of tumor concentration, as well as the magnitude of anisotropic tumor…

Numerical Analysis · Mathematics 2015-05-12 Amir Gholami , Andreas Mang , George Biros

Microscopy is one of the most essential imaging techniques in life sciences. High-quality images are required in order to solve (potentially life-saving) biomedical research problems. Many microscopy techniques do not achieve sufficient…

Computer Vision and Pattern Recognition · Computer Science 2018-10-24 Joris Roels , Jan Aelterman , Jonas De Vylder , Hiep Luong , Yvan Saeys , Wilfried Philips

Dataset distillation provides an effective approach to reduce memory and computational costs by optimizing a compact dataset that achieves performance comparable to the full original. However, for large-scale datasets and complex deep…

Computer Vision and Pattern Recognition · Computer Science 2025-11-14 Xinhao Zhong , Shuoyang Sun , Xulin Gu , Zhaoyang Xu , Yaowei Wang , Min Zhang , Bin Chen

The design of an experiment, e.g., the setting of initial conditions, strongly influences the accuracy of the whole process of determining model parameters from data. We impose a sensitivity-based approach for choosing optimal design…

Numerical Analysis · Mathematics 2016-02-11 Stefan Kindermann , Stepan Papacek

The life of a cell is governed by highly dynamical microscopic processes. Two notable examples are the diffusion of membrane receptors and the kinetics of transcription factors governing the rates of gene expression. Different fluorescence…

Quantitative Methods · Quantitative Biology 2020-04-03 Maxime Woringer , Ignacio Izeddin , Cyril Favard , Hugues Berry

Due to the high potential for abuse of GenAI systems, the task of detecting synthetic images has recently become of great interest to the research community. Unfortunately, existing image-space detectors quickly become obsolete as new…

Computer Vision and Pattern Recognition · Computer Science 2024-06-14 George Cazenavette , Avneesh Sud , Thomas Leung , Ben Usman

Deconvolution of astronomical images is a key aspect of recovering the intrinsic properties of celestial objects, especially when considering ground-based observations. This paper explores the use of diffusion models (DMs) and the Diffusion…

Instrumentation and Methods for Astrophysics · Physics 2025-01-22 Alessio Spagnoletti , Alexandre Boucaud , Marc Huertas-Company , Wassim Kabalan , Biswajit Biswas

Inverse design problems are common in engineering and materials science. The forward direction, i.e., computing output quantities from design parameters, typically requires running a numerical simulation, such as a FEM, as an intermediate…

Machine Learning · Computer Science 2026-02-18 Jens U. Kreber , Christian Weißenfels , Joerg Stueckler

This paper introduces a statistical treatment of inverse problems constrained by models with stochastic terms. The solution of the forward problem is given by a distribution represented numerically by an ensemble of simulations. The goal is…

Optimization and Control · Mathematics 2019-04-17 Emil M. Constantinescu , Noemi Petra , Julie Bessac , Cosmin G. Petra

Image restoration, which aims to recover high-quality images from their corrupted counterparts, often faces the challenge of being an ill-posed problem that allows multiple solutions for a single input. However, most deep learning based…

Computer Vision and Pattern Recognition · Computer Science 2024-04-16 Wenyi Lian , Wenjing Lian , Ziwei Luo

The choice of prior is central to solving ill-posed imaging inverse problems, making it essential to select one consistent with the measurements $y$ to avoid severe bias. In Bayesian inverse problems, this could be achieved by evaluating…

Machine Learning · Computer Science 2026-05-01 Frederic Wang , Katherine L. Bouman

Many imaging science tasks can be modeled as a discrete linear inverse problem. Solving linear inverse problems is often challenging, with ill-conditioned operators and potentially non-unique solutions. Embedding prior knowledge, such as…

Numerical Analysis · Mathematics 2023-12-07 Elizabeth Newman , Jack Michael Solomon , Matthias Chung

In medical applications, weakly supervised anomaly detection methods are of great interest, as only image-level annotations are required for training. Current anomaly detection methods mainly rely on generative adversarial networks or…

Image and Video Processing · Electrical Eng. & Systems 2022-10-06 Julia Wolleb , Florentin Bieder , Robin Sandkühler , Philippe C. Cattin

This paper considers the problem of utilizing a large-scale text-to-image diffusion model to tackle the challenging Inexact Segmentation (IS) task. Unlike traditional approaches that rely heavily on discriminative-model-based paradigms or…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Tianjiao Zhang , Fei Zhang , Jiangchao Yao , Ya Zhang , Yanfeng Wang

Inverse rendering, the process of inferring scene properties from images, is a challenging inverse problem. The task is ill-posed, as many different scene configurations can give rise to the same image. Most existing solutions incorporate…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Linjie Lyu , Ayush Tewari , Marc Habermann , Shunsuke Saito , Michael Zollhöfer , Thomas Leimkühler , Christian Theobalt

We propose self-diffusion, a novel framework for solving inverse problems without relying on pretrained generative models. Traditional diffusion-based approaches require training a model on a clean dataset to learn to reverse the forward…

Machine Learning · Computer Science 2025-12-09 Guanxiong Luo , Shoujin Huang , Yanlong Yang

Diffusion models represent the state-of-the-art for solving inverse problems such as image restoration tasks. Diffusion-based inverse solvers incorporate a likelihood term to guide prior sampling, generating data consistent with the…

Machine Learning · Computer Science 2026-03-03 Bahareh Tolooshams , Aditi Chandrashekar , Rayhan Zirvi , Abbas Mammadov , Jiachen Yao , Chuwei Wang , Anima Anandkumar