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In this two-part paper, we present a novel framework and methodology to analyze data from certain image-based biochemical assays, e.g., ELISPOT and Fluorospot assays. In this second part, we focus on our algorithmic contributions. We…

Signal Processing · Electrical Eng. & Systems 2018-10-19 Pol del Aguila Pla , Joakim Jaldén

Cell detection and counting in the image-based ELISPOT and Fluorospot immunoassays is considered a bottleneck. The task has remained hard to automatize, and biomedical researchers often have to rely on results that are not accurate.…

Image and Video Processing · Electrical Eng. & Systems 2018-10-24 Pol del Aguila Pla , Joakim Jaldén

Accurate cell detection and counting in the image-based ELISpot and FluoroSpot immunoassays is a challenging task. Recently proposed methodology matches human accuracy by leveraging knowledge of the underlying physical process of these…

Image and Video Processing · Electrical Eng. & Systems 2019-04-23 Pol del Aguila Pla , Vidit Saxena , Joakim Jaldén

Fluorescent Optical Tomography (FOT) is a new bio-medical imaging method with wider industrial applications. It is currently intensely researched since it is very precise and with no side effects for humans, as it uses non-ionising red and…

Analysis of PDEs · Mathematics 2019-10-29 Nikos Katzourakis

Using diffusion models to solve inverse problems is a growing field of research. Current methods assume the degradation to be known and provide impressive results in terms of restoration quality and diversity. In this work, we leverage the…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Charles Laroche , Andrés Almansa , Eva Coupete

Inverse problems have many applications in science and engineering. In Computer vision, several image restoration tasks such as inpainting, deblurring, and super-resolution can be formally modeled as inverse problems. Recently, methods have…

Computer Vision and Pattern Recognition · Computer Science 2024-09-19 Sai Bharath Chandra Gutha , Ricardo Vinuesa , Hossein Azizpour

We propose a general framework for conditional sampling in PDE-based inverse problems, targeting the recovery of whole solutions from extremely sparse or noisy measurements. This is accomplished by a function-space diffusion model and…

Machine Learning · Computer Science 2026-02-06 Jiachen Yao , Abbas Mammadov , Julius Berner , Gavin Kerrigan , Jong Chul Ye , Kamyar Azizzadenesheli , Anima Anandkumar

Diffusion models have achieved remarkable success in imaging inverse problems owing to their powerful generative capabilities. However, existing approaches typically rely on models trained for specific degradation types, limiting their…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Zhen Wang , Hongyi Liu , Zhihui Wei

We consider the inverse problem of estimating parameters of a driven diffusion (e.g., the underlying fluid flow, diffusion coefficient, or source terms) from point measurements of a passive scalar (e.g., the concentration of a pollutant).…

Numerical Analysis · Mathematics 2019-05-22 Jeff Borggaard , Nathan E. Glatt-Holtz , Justin A. Krometis

This paper introduces two key contributions aimed at improving the speed and quality of images generated through inverse diffusion processes. The first contribution involves reparameterizing the diffusion process in terms of the angle on a…

Machine Learning · Computer Science 2026-02-26 Zhenkai Zhang , Krista A. Ehinger , Tom Drummond

We study an inverse problem for Light Sheet Fluorescence Microscopy (LSFM), where the density of fluorescent molecules needs to be reconstructed. Our first step is to present a mathematical model to describe the measurements obtained by an…

Analysis of PDEs · Mathematics 2020-08-26 Evelyn Cueva , Matias Courdurier , Axel Osses , Victor Castañeda , Benjamin Palacios , Steffen Härtel

Diffusion models are powerful tools for sampling from high-dimensional distributions by progressively transforming pure noise into structured data through a denoising process. When equipped with a guidance mechanism, these models can also…

Machine Learning · Computer Science 2026-05-04 Saeed Mohseni-Sehdeh , Walid Saad , Kei Sakaguchi , Tao Yu

Image restoration aims to recover high-quality images from degraded observations. When the degradation process is known, the recovery problem can be formulated as an inverse problem, and in a Bayesian context, the goal is to sample a clean…

Image and Video Processing · Electrical Eng. & Systems 2025-10-13 Darshan Thaker , Abhishek Goyal , René Vidal

Diffusion models have emerged as a key pillar of foundation models in visual domains. One of their critical applications is to universally solve different downstream inverse tasks via a single diffusion prior without re-training for each…

Machine Learning · Computer Science 2023-10-03 Morteza Mardani , Jiaming Song , Jan Kautz , Arash Vahdat

In this paper, we propose a new model to segment cells in phase contrast microscopy images. Cell images collected from the similar scenario share a similar background. Inspired by this, we separate cells from the background in images by…

Computer Vision and Pattern Recognition · Computer Science 2019-04-02 Lin Zhang

Diffusion models have recently emerged as powerful generative priors for solving inverse problems. However, training diffusion models in the pixel space are both data-intensive and computationally demanding, which restricts their…

Computer Vision and Pattern Recognition · Computer Science 2024-04-17 Bowen Song , Soo Min Kwon , Zecheng Zhang , Xinyu Hu , Qing Qu , Liyue Shen

Diffusion models have emerged as powerful generative tools with applications in computer vision and scientific machine learning (SciML), where they have been used to solve large-scale probabilistic inverse problems. Traditionally, these…

Diffusion models have recently been shown to excel in many image reconstruction tasks that involve inverse problems based on a forward measurement operator. A common framework uses task-agnostic unconditional models that are later…

Computer Vision and Pattern Recognition · Computer Science 2024-06-17 Alper Güngör , Bahri Batuhan Bilecen , Tolga Çukur

Diffusion models have recently demonstrated notable success in solving inverse problems. However, current diffusion model-based solutions typically require a large number of function evaluations (NFEs) to generate high-quality images…

Computer Vision and Pattern Recognition · Computer Science 2024-12-06 Tianyu Chen , Zhendong Wang , Mingyuan Zhou

In recent years we have witnessed a growth in mathematics for deep learning, which has been used to solve inverse problems of partial differential equations (PDEs). However, most deep learning-based inversion methods either require paired…

Numerical Analysis · Mathematics 2024-04-23 Enze Jiang , Jishen Peng , Zheng Ma , Xiong-Bin Yan
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