Related papers: Development of models for predicting Torsade de Po…
Torsades de pointes (TdP) is an irregular heart rhythm as a side effect of drugs and may cause sudden cardiac death. A machine learning model that can accurately identify drug TdP risk is necessary. This study uses multinomial logistic…
Torsades de pointes (TdP) is an irregular heart rhythm characterized by faster beat rates and potentially could lead to sudden cardiac death. Much effort has been invested in understanding the drug-induced TdP in preclinical studies.…
The human {\it ether-a-go-go} (hERG) potassium channel (K$_\text{v}11.1$) plays a critical role in mediating cardiac action potential. The blockade of this ion channel can potentially lead fatal disorder and/or long QT syndrome. Many drugs…
The evaluation of drug-induced Torsades de pointes (TdP) risks is crucial in drug safety assessment. In this study, we discuss machine learning approaches in the prediction of drug-induced TdP risks using preclinical data. Specifically, the…
Drug-mediated blockade of the voltage-gated potassium channel(hERG) and the voltage-gated sodium channel (Nav1.5) can lead to severe cardiovascular complications. This rising concern has been reflected in the drug development arena, as the…
Cardiovascular diseases (CVDs) remain a leading cause of death globally, necessitating continuous, accurate non-invasive cardiac monitoring. While non-contact radar-based approaches show great promise, they often employ a single…
The link between in vitro hERG ion channel inhibition and subsequent in vivo QT interval prolongation, a critical risk factor for the development of arrythmias such as Torsade de Pointes, is so well established that in vitro hERG activity…
Monitoring and analyzing electrocardiogram (ECG) signals, even under varying physiological conditions, including those influenced by physical activity, drugs and stress, is crucial to accurately assess cardiac health. However, current…
The ability to accurately infer cardiac electrophysiological (EP) properties is key to improving arrhythmia diagnosis and treatment. In this work, we developed a physics-informed neural networks (PINNs) framework to predict how different…
Combination pharmacotherapy offers substantial therapeutic advantages but also poses substantial risks of adverse drug reactions (ADRs). The accurate prediction of ADRs with interpretable computational methods is crucial for clinical safety…
Pain is a significant global health issue, and the current treatment options for pain management have limitations in terms of effectiveness, side effects, and potential for addiction. There is a pressing need for improved pain treatments…
Large prospective epidemiological studies acquire cardiovascular magnetic resonance (CMR) images for pre-symptomatic populations and follow these over time. To support this approach, fully automatic large-scale 3D analysis is essential. In…
Radiation therapy is the primary method used to treat cancer in the clinic. Its goal is to deliver a precise dose to the planning target volume (PTV) while protecting the surrounding organs at risk (OARs). However, the traditional workflow…
Targeted protein degradation (TPD) induced by small molecules has emerged as a rapidly evolving modality in drug discovery, targeting proteins traditionally considered "undruggable". Proteolysis-targeting chimeras (PROTACs) and molecular…
Global single-valued biomarkers of cardiac function typically used in clinical practice, such as ejection fraction, provide limited insight on the true 3D cardiac deformation process and hence, limit the understanding of both healthy and…
Coronary heart disease (CHD) is a leading cause of death worldwide and contributes significantly to annual healthcare expenditures. To develop a non-invasive diagnostic approach, we designed a model based on a multilayer perceptron (MLP)…
Drug combination therapy has become a increasingly promising method in the treatment of cancer. However, the number of possible drug combinations is so huge that it is hard to screen synergistic drug combinations through wet-lab…
Endocrine-disrupting chemicals (EDCs) threaten human health, ecosystems, and biodiversity by interfering with hormonal signaling pathways conserved across vertebrates. Traditional in vivo assays are costly and time-consuming, limiting their…
Tremor is a key diagnostic feature of Parkinson's Disease (PD), Essential Tremor (ET), and other central nervous system (CNS) disorders. Clinicians or trained raters assess tremor severity with TETRAS scores by observing patients. Lacking…
Arrhythmias are irregularities in the hearts electrical system which cause rapid and irregular heartbeats. These heart conditions affect over 33 million people globally and significantly increase the risk of severe complications, including…