English
Related papers

Related papers: netgwas: An R Package for Network-Based Genome-Wid…

200 papers

Networks or graphs are widely used across the sciences to represent relationships of many kinds. igraph (https://igraph.org) is a general-purpose software library for graph construction, analysis, and visualisation, combining fast and…

Discovering gene-disease associations is crucial for understanding disease mechanisms, yet identifying these associations remains challenging due to the time and cost of biological experiments. Computational methods are increasingly vital…

Artificial Intelligence · Computer Science 2025-01-15 Wentao Cui , Shoubo Li , Chen Fang , Qingqing Long , Chengrui Wang , Xuezhi Wang , Yuanchun Zhou

Preferential attachment (PA) network models have a wide range of applications in various scientific disciplines. Efficient generation of large-scale PA networks helps uncover their structural properties and facilitate the development of…

Computation · Statistics 2023-10-18 Yelie Yuan , Tiandong Wang , Jun Yan , Panpan Zhang

With the recent advent of high-throughput genotyping techniques, genetic data for genome-wide association studies (GWAS) have become increasingly available, which entails the development of efficient and effective statistical approaches.…

Applications · Statistics 2015-02-04 Jiahan Li , Wei Zhong , Runze Li , Rongling Wu

The inference of network topologies from relational data is an important problem in data analysis. Exemplary applications include the reconstruction of social ties from data on human interactions, the inference of gene co-expression…

Social and Information Networks · Computer Science 2021-02-24 Giona Casiraghi , Vahan Nanumyan , Ingo Scholtes , Frank Schweitzer

Proteins perform much of the work in living organisms, and consequently the development of efficient computational methods for protein representation is essential for advancing large-scale biological research. Most current approaches…

Quantitative Methods · Quantitative Biology 2023-06-09 Francesco Ceccarelli , Lorenzo Giusti , Sean B. Holden , Pietro Liò

Successful management of wildlife populations requires accurate estimates of abundance. Abundance estimates can be confounded by imperfect detection during wildlife surveys. N-mixture models enable quantification of detection probability…

Applications · Statistics 2018-08-17 Timothy D. Meehan , Nicole L. Michel , Håvard Rue

RSNet is an open-source R package that provides a resampling-based framework for robust and interpretable network inference, designed to address the limited-sample-size challenges common in high-dimensional data. It supports both the…

Machine Learning · Computer Science 2026-05-14 Ziwei Huang , Zeyuan Song , Paola Sebastiani , Stefano Monti

Technology and collaboration enable dramatic increases in the size of psychological and psychiatric data collections, but finding structure in these large data sets with many collected variables is challenging. Decision tree ensembles like…

Machine Learning · Statistics 2017-02-15 Patrick J. Miller , Gitta H. Lubke , Daniel B. McArtor , C. S. Bergeman

The problem of predicting links in large networks is an important task in a variety of practical applications, including social sciences, biology and computer security. In this paper, statistical techniques for link prediction based on the…

Applications · Statistics 2021-09-01 Francesco Sanna Passino , Anna S. Bertiger , Joshua C. Neil , Nicholas A. Heard

In real-world networks, predicting the weight (strength) of links is as crucial as predicting the existence of the links themselves. Previous studies have primarily used shallow graph features for link weight prediction, limiting the…

Social and Information Networks · Computer Science 2024-10-29 Jinbi Liang , Cunlai Pu , Xiangbo Shu , Yongxiang Xia , Chengyi Xia

Graph neural networks (GNNs) have been successfully applied in many structured data domains, with applications ranging from molecular property prediction to the analysis of social networks. Motivated by the broad applicability of GNNs, we…

Machine Learning · Computer Science 2021-10-12 Clemens Damke , Eyke Hüllermeier

Learning continuous-time dynamics on complex networks is crucial for understanding, predicting and controlling complex systems in science and engineering. However, this task is very challenging due to the combinatorial complexities in the…

Social and Information Networks · Computer Science 2020-06-19 Chengxi Zang , Fei Wang

The problem of learning the structure of a high dimensional graphical model from data has received considerable attention in recent years. In many applications such as sensor networks and proteomics it is often expensive to obtain samples…

Machine Learning · Statistics 2016-04-08 Gautam Dasarathy , Aarti Singh , Maria-Florina Balcan , Jong Hyuk Park

The recent explosion of genomic data has underscored the need for interpretable and comprehensive analyses that can capture complex phylogenetic relationships within and across species. Recombination, reassortment and horizontal gene…

Quantitative Methods · Quantitative Biology 2016-09-28 Pablo G. Camara , Arnold J. Levine , Raul Rabadan

Genome-Wide Association Studies are typically conducted using linear models to find genetic variants associated with common diseases. In these studies, association testing is done on a variant-by-variant basis, possibly missing out on…

Recent deep learning models have moved beyond low-dimensional regular grids such as image, video, and speech, to high-dimensional graph-structured data, such as social networks, brain connections, and knowledge graphs. This evolution has…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-10-22 Lingxiao Ma , Zhi Yang , Youshan Miao , Jilong Xue , Ming Wu , Lidong Zhou , Yafei Dai

Graph Neural Networks (GNNs) have excelled in predicting graph properties in various applications ranging from identifying trends in social networks to drug discovery and malware detection. With the abundance of new architectures and…

Machine Learning · Computer Science 2024-06-06 Roya Aliakbarisani , Robert Jankowski , M. Ángeles Serrano , Marián Boguñá

Gene Ontology (GO) terms are frequently used to score alignments between protein-protein interaction (PPI) networks. Methods exist to measure the GO similarity between two proteins in isolation, but pairs of proteins in a network alignment…

Molecular Networks · Quantitative Biology 2017-04-06 Wayne B. Hayes , Nil Mamano

Tangled Program Graph (TPG) is a reinforcement learning technique based on genetic programming concepts. On state-of-the-art learning environments, TPGs have been shown to offer comparable competence with Deep Neural Networks (DNNs), for a…

Neural and Evolutionary Computing · Computer Science 2020-12-16 Karol Desnos , Nicolas Sourbier , Pierre-Yves Raumer , Olivier Gesny , Maxime Pelcat