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Computer simulation of "virtual interventions" may inform optimal valve repair for a given patient prior to intervention. However, the paucity of noninvasive methods to determine in vivo mechanical parameters of valves limits the accuracy…

Quantitative Methods · Quantitative Biology 2025-07-09 Wensi Wu , Mitchell Daneker , Christian Herz , Hannah Dewey , Jeffrey A. Weiss , Alison M. Pouch , Lu Lu , Matthew A. Jolley

In causal inference, and specifically in the \textit{Causes of Effects} problem, one is interested in how to use statistical evidence to understand causation in an individual case, and so how to assess the so-called {\em probability of…

Methodology · Statistics 2018-10-23 Fabio Corradi , Monica Musio

Approximate Bayesian Computation (ABC) has become one of the major tools of likelihood-free statistical inference in complex mathematical models. Simultaneously, stochastic differential equations (SDEs) have developed to an established tool…

Computation · Statistics 2019-07-08 Evelyn Buckwar , Massimiliano Tamborrino , Irene Tubikanec

One major impediment to the wider use of deep learning for clinical decision making is the difficulty of assigning a level of confidence to model predictions. Currently, deep Bayesian neural networks and sparse Gaussian processes are the…

Hardware performance counters (HPCs) that measure low-level architectural and microarchitectural events provide dynamic contextual information about the state of the system. However, HPC measurements are error-prone due to non determinism…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-02-23 Subho S. Banerjee , Saurabh Jha , Zbigniew T. Kalbarczyk , Ravishankar K. Iyer

Cerebral aneurysms are pathological dilations of intracranial arteries that can rupture with devastating consequences, including subarachnoid hemorrhage, stroke, and death. Accumulating evidence indicates that local hemodynamic forces play…

Other Quantitative Biology · Quantitative Biology 2025-05-22 Reza Bozorgpour , Pilwan Kim

In view of the recent paradigm shift in deep AI based image processing methods, medical image processing has advanced considerably. In this study, we propose a novel deep neural network (DNN), entitled InceptNet, in the scope of medical…

Image and Video Processing · Electrical Eng. & Systems 2023-09-06 Amirhossein Sajedi , Mohammad Javad Fadaeieslam

Recent years have seen growing interest in the diagnosis of Coronary Artery Disease (CAD) with machine learning methods to reduce the cost and health implications of conventional diagnosis. This paper introduces a CAD diagnosis method with…

Machine Learning · Computer Science 2021-09-24 Ali Yavari , Amir Rajabzadeh , Fardin Abdali-Mohammadi

In standard hospital blood tests, the traditional process requires doctors to manually isolate leukocytes from microscopic images of patients' blood using microscopes. These isolated leukocytes are then categorized via automatic leukocyte…

Computer Vision and Pattern Recognition · Computer Science 2024-01-11 Yifei Chen , Chenyan Zhang , Ben Chen , Yiyu Huang , Yifei Sun , Changmiao Wang , Xianjun Fu , Yuxing Dai , Feiwei Qin , Yong Peng , Yu Gao

The early detection and prediction of cardiovascular diseases are crucial for reducing the severe morbidity and mortality associated with these conditions worldwide. A multi-headed self-attention mechanism, widely used in natural language…

Many clinical deep learning algorithms are population-based and difficult to interpret. Such properties limit their clinical utility as population-based findings may not generalize to individual patients and physicians are reluctant to…

Signal Processing · Electrical Eng. & Systems 2020-12-01 Dani Kiyasseh , Tingting Zhu , David A. Clifton

Motivation: Modeling biological signaling networks using ordinary differential equations (ODEs) has proven to be a powerful technique for generating insight into cellular dynamics, but it typically requires estimating rate parameters based…

Molecular Networks · Quantitative Biology 2011-03-07 Tri Hieu Nim , Le Luo , Marie-Véronique Clément , Jacob K. White , Lisa Tucker-Kellogg

We present Causal Posterior Estimation (CPE), a novel method for Bayesian inference in simulator models, i.e., models where the evaluation of the likelihood function is intractable or too computationally expensive, but where one can…

Machine Learning · Computer Science 2025-05-28 Simon Dirmeier , Antonietta Mira

In recent years, coded distributed computing (CDC) has attracted significant attention, because it can efficiently facilitate many delay-sensitive computation tasks against unexpected latencies in distributed computing systems. Despite such…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-07-12 Baoqian Wang , Junfei Xie , Kejie Lu , Yan Wan , Shengli Fu

Parameter calibration is essential for reducing uncertainty and improving predictive fidelity in physics-based models, yet it is often limited by the high computational cost of model evaluations. Bayesian calibration methods provide a…

Methodology · Statistics 2026-01-21 Maike F. Holthuijzen , Atlanta Chakraborty , Elizabeth Krath , Tommie Catanach

Cardiovascular disease and chronic kidney disease are major complications of diabetes, leading to high morbidity and mortality. Early detection of these conditions is critical, yet traditional diagnostic markers often lack sensitivity in…

Other Quantitative Biology · Quantitative Biology 2025-10-20 Syed Ibad Hasnain

Cardiovascular disease (CVD) risk prediction models are essential for identifying high-risk individuals and guiding preventive actions. However, existing models struggle with the challenges of real-world clinical practice as they…

Representing uncertainty in causal discovery is a crucial component for experimental design, and more broadly, for safe and reliable causal decision making. Bayesian Causal Discovery (BCD) offers a principled approach to encapsulating this…

In this paper we consider a statistical estimation problem known as atomic deconvolution. Introduced in reliability, this model has a direct application when considering biological data produced by flow cytometers. In these experiments,…

Statistics Theory · Mathematics 2017-10-12 Manon Costa , Sébastien Gadat , Pauline Gonnord , Laurent Risser

We introduce ABC-Dataset, a collection of one million Computer-Aided Design (CAD) models for research of geometric deep learning methods and applications. Each model is a collection of explicitly parametrized curves and surfaces, providing…