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We present an equilibrium statistical-mechanical theory of selectivity in biological ion channels. In doing so, we introduce a grand canonical ensemble for ions in a channel's selectivity filter coupled to internal and external bath…

Biological Physics · Physics 2016-05-11 D. G. Luchinsky , W. A. T. Gibby , I. Kaufman , D. A. Timucin , P. V. E. McClintock

A discrete rate theory for general multi-ion channels is presented, in which the continuous dynamics of ion diffusion is reduced to transitions between Markovian discrete states. In an open channel, the ion permeation process involves three…

Biological Physics · Physics 2012-06-29 Wan Chen , Radek Erban , S. Jonathan Chapman

We consider a coupled system of Navier Stokes, Maxwell Stefan and Poisson Boltzmann equations by incorporating the variation of dielectric constant, which governs the electro osmotic flow in nano channel, describing the evolution of the…

Fluid Dynamics · Physics 2016-02-24 Rajendra Padidhapu , Shahnaz Bathul , V. Brahmajirao

A simple theory of ion permeation through a channel is presented, in which diffusion occurs according to Fick's law and drift according to Ohm's law, in the electric field determined by all the charges present. This theory accounts for…

Biomolecules · Quantitative Biology 2016-10-17 Bob Eisenberg

A model of mobile, charged ion channels embedded in a biomembrane is investigated. The ion channels fluctuate between an opened and a closed state according to a simple two-state reaction scheme whereas the total number of ion channels is a…

Pattern Formation and Solitons · Physics 2009-11-11 Ronny Peter , Walter Zimmermann

This work examines the geometric mean of concentrations and its behavior in various situations, as well as the reversal permanent charge problem, the charge sharing seen in x-ray diffraction. Observations are obtained from analytical…

Statistical Mechanics · Physics 2020-09-22 Hamid Mofidi

The transient behaviour of organic electrochemical transistors (OECT) is complex due to mixed ionic-electronic properties that play a central role in bioelectronics, sensing and neuromorphic applications. We investigate the impedance…

Materials Science · Physics 2024-08-06 Juan Bisquert , Scott T. Keene

In the context of describing electrons in solids as a fluid in the hydrodynamic regime, we consider a flow of electrons in a channel of finite width, i.e.~a Poiseuille flow. The electrons are accelerated by a constant electric field. We…

Mesoscale and Nanoscale Physics · Physics 2018-12-05 Johanna Erdmenger , Ioannis Matthaiakakis , Rene Meyer , David Rodríguez Fernández

In this paper we develop a simple theory to study the effects of ionic size on ionic distributions around a charged spherical particle. We include a correction to the regular Poisson-Boltzmann equation in order to take into account the size…

Soft Condensed Matter · Physics 2017-08-30 Thiago Colla , Lucas Nunes Lopes , Alexandre P. dos Santos

We study the variation of the dielectric response of ionic aqueous solutions as function of their ionic strength. The effect of salt on the dielectric constant appears through the coupling between ions and dipolar water molecules. On a…

Soft Condensed Matter · Physics 2013-11-19 Amir Levy , David Andelman , Henri Orland

We consider ionic electrodiffusion in fluids, described by the Nernst-Planck-Navier-Stokes system in bounded domains, in two dimensions, with Dirichlet boundary conditions for the Navier-Stokes and Poisson equations, and blocking (vanishing…

Analysis of PDEs · Mathematics 2018-12-26 Peter Constantin , Mihaela Ignatova

Recent experimental advances in nanofluidics have allowed to explore ion transport across molecular-scale pores, in particular for iontronic applications. Two dimensional nanochannels -- in which a single molecular layer of electrolyte is…

Soft Condensed Matter · Physics 2025-01-22 Damien Toquer , Lydéric Bocquet , Paul Robin

A position-dependent stochastic diffusion model of gating in ion channels is developed by considering the spatial variation of the diffusion coefficient between the closed and open states. It is assumed that a sensor which regulates the…

Mesoscale and Nanoscale Physics · Physics 2014-07-24 Samuel Robert Vaccaro

Water is essential for almost every aspect of life on our planet and, unsurprisingly, its properties have been studied in great detail. However, disproportionately little remains known about the electrical properties of interfacial and…

We study the interaction between two neutral plane-parallel dielectric bodies in the presence of a highly asymmetric ionic fluid, containing multivalent as well as monovalent (salt) ions. Image charge interactions, due to dielectric…

Soft Condensed Matter · Physics 2015-06-11 Matej Kanduc , Ali Naji , Jan Forsman , Rudolf Podgornik

This is an early but comprehensive review of the PNP Poisson Nernst Planck theory of ion channels. Extensive reference is made to the earlier literature. The starting place for this theory of open channels is a theory of electrodiffusion…

Biomolecules · Quantitative Biology 2010-09-16 Bob Eisenberg

Using both analytic and numerical analyses of the Poisson-Nernst-Planck equations we theoretically investigate the electric conductivity of a conical channel, which in accordance with recent experiments exhibits a strong non-linear pressure…

Soft Condensed Matter · Physics 2022-10-19 Willem Boon , Tim Veenstra , Marjolein Dijkstra , René van Roij

There is a large body of literature investigating the static and dynamic properties of polyelectrolytes due both to their widespread application in industrial processes and their ubiquitous presence in biology. Because of their highly…

Soft Condensed Matter · Physics 2016-01-20 Florian Fahrenberger , Owen A. Hickey , Jens Smiatek , Christian Holm

We investigate the effect of adsorption-desorption phenomenon of ions in an asymmetric electrolytic cell at open circuit conditions. Our approach is based on the Poisson-Nernst-Planck theory for electrolytes and the kinetic model of…

Chemical Physics · Physics 2017-12-06 S. Bousiadi , I. Lelidis

A Poisson-Nernst-Planck-Fermi (PNPF) theory is developed for studying ionic transport through biological ion channels. Our goal is to deal with the finite size of particle using a Fermi like distribution without calculating the forces…

Biological Physics · Physics 2015-06-23 Jinn-Liang Liu , Bob Eisenberg