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Background: The concept of combinatorial biomarkers was conceived around 2010: it was noticed that simple biomarkers are often inadequate for recognizing and characterizing complex diseases. Methods: Here we present an algorithmic search…

Neurons and Cognition · Quantitative Biology 2013-12-09 Balazs Szalkai , Vince K. Grolmusz , Vince I. Grolmusz , Coalition Against Major Diseases

Association Rule Mining (ARM) is a fundamental task for knowledge discovery in tabular data and is widely used in high-stakes decision-making. Classical ARM methods rely on frequent itemset mining, leading to rule explosion and poor…

Artificial Intelligence · Computer Science 2026-02-18 Erkan Karabulut , Daniel Daza , Paul Groth , Martijn C. Schut , Victoria Degeler

Association rules are useful to discover relationships, which are mostly hidden, between the different items in large datasets. Symbolic models are the principal tools to extract association rules. This basic technique is time-consuming,…

Databases · Computer Science 2021-07-20 Shadi Al Shehabi , Abdullatif Baba

Association Rule Mining (ARM) aims to discover patterns between features in datasets in the form of propositional rules, supporting both knowledge discovery and interpretable machine learning in high-stakes decision-making. However, in…

Machine Learning · Computer Science 2026-01-06 Erkan Karabulut , Daniel Daza , Paul Groth , Victoria Degeler

Healthcare institutes enrich the repository of patients' disease related information in an increasing manner which could have been more useful by carrying out relational analysis. Data mining algorithms are proven to be quite useful in…

Databases · Computer Science 2014-01-14 Mahmood A. Rashid , Md Tamjidul Hoque , Abdul Sattar

Discovering frequent itemset is a key difficulty in significant data mining applications, such as the discovery of association rules, strong rules, episodes, and minimal keys. The problem of developing models and algorithms for multilevel…

Databases · Computer Science 2012-09-28 Pratima Gautam , Rahul Shukla

How can we mine frequent path regularities from a graph with edge labels and vertex attributes? The task of association rule mining successfully discovers regular patterns in item sets and substructures. Still, to our best knowledge, this…

Databases · Computer Science 2024-09-23 Yuya Sasaki , Panagiotis Karras

The process of data mining produces various patterns from a given data source. The most recognized data mining tasks are the process of discovering frequent itemsets, frequent sequential patterns, frequent sequential rules and frequent…

Databases · Computer Science 2014-02-13 Thabet Slimani , Amor Lazzez

There are several mining algorithms of association rules. One of the most popular algorithms is Apriori that is used to extract frequent itemsets from large database and getting the association rule for discovering the knowledge. Based on…

Databases · Computer Science 2014-03-18 Mohammed Al-Maolegi , Bassam Arkok

Association Rule Mining is a machine learning method for discovering the interesting relations between the attributes in a huge transaction database. Typically, algorithms for Association Rule Mining generate a huge number of association…

Neural and Evolutionary Computing · Computer Science 2021-04-19 Iztok Fister , Iztok Fister

Over the years, data mining has attracted most of the attention from the research community. The researchers attempt to develop faster, more scalable algorithms to navigate over the ever increasing volumes of spatial gene expression data in…

Databases · Computer Science 2010-01-14 M. Anandhavalli , M. K. Ghose , K. Gauthaman

The paper presents a novel software framework for Association Rule Mining named uARMSolver. The framework is written fully in C++ and runs on all platforms. It allows users to preprocess their data in a transaction database, to make…

Databases · Computer Science 2020-10-22 Iztok Fister , Iztok Fister

When faced with a new dataset, most practitioners begin by performing exploratory data analysis to discover interesting patterns and characteristics within data. Techniques such as association rule mining are commonly applied to uncover…

Machine Learning · Computer Science 2021-02-03 Andrew Lensen

Mining association rules is a popular and well researched method for discovering interesting relations between variables in large databases. A practical problem is that at medium to low support values often a large number of frequent…

Databases · Computer Science 2008-12-18 Michael Hahsler , Christian Buchta , Kurt Hornik

Learning causal relationships among a set of variables, as encoded by a directed acyclic graph, from observational data is complicated by the presence of unobserved confounders. Instrumental variables (IVs) are a popular remedy for this…

Methodology · Statistics 2025-04-17 Jing Zou , Wei Li , Wei Lin

In recent years, the problem of association rule mining in transactional data has been well studied. We propose to extend the discovery of classical association rules to the discovery of association rules of conjunctive queries in arbitrary…

Databases · Computer Science 2007-05-23 Bart Goethals , Jan Van den Bussche

Simultaneous variable selection and statistical inference is challenging in high-dimensional data analysis. Most existing post-selection inference methods require explicitly specified regression models, which are often linear, as well as…

Methodology · Statistics 2026-03-19 Shangyuan Ye , Shauna Rakshe , Ye Liang

Our aging population increasingly suffers from multiple chronic diseases simultaneously, necessitating the comprehensive treatment of these conditions. Finding the optimal set of drugs for a combinatorial set of diseases is a combinatorial…

Artificial Intelligence · Computer Science 2016-11-16 Pranjul Yadav , Lisiane Prunelli , Alexander Hoff , Michael Steinbach , Bonnie Westra , Vipin Kumar , Gyorgy Simon

With the growing size of data sets, feature selection becomes increasingly important. Taking interactions of original features into consideration will lead to extremely high dimension, especially when the features are categorical and…

Databases · Computer Science 2021-04-13 Qiuqiang Lin , Chuanhou Gao

Observed associations in a database may be due in whole or part to variations in unrecorded (latent) variables. Identifying such variables and their causal relationships with one another is a principal goal in many scientific and practical…

Machine Learning · Computer Science 2012-12-12 Ricardo Silva , Richard Scheines , Clark Glymour , Peter L. Spirtes
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