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One of the hallmarks of pre-migratory tumors is the progressive loss of compact morphology. To investigate how tumors may intrinsically regulate their shape during growth, we employ a three-dimensional (3D) vertex model of multicellular…

Soft Condensed Matter · Physics 2026-02-09 Urban Železnik , Matej Krajnc , Tanmoy Sarkar

During development, epithelial tissues undergo extensive morphogenesis based on coordinated changes of cell shape and position over time. Continuum mechanics describes tissue mechanical state and shape changes in terms of strain and stress.…

Cell Behavior · Quantitative Biology 2012-05-14 Isabelle Bonnet , Philippe Marcq , Floris Bosveld , Luc Fetler , Yohanns Bellaiche , Francois Graner

We investigate a continuum mechanical model for an adherent cell on two dimensional adhesive micropatterned substrates. The cell is modeled as an isotropic and homogeneous elastic material subject to uniform internal contractile stresses.…

Biological Physics · Physics 2013-12-30 Shiladitya Banerjee , Rastko Sknepnek , M. Cristina Marchetti

We study the influence of cell-level mechanical heterogeneity in epithelial tissues using a vertex-based model. Heterogeneity in single cell stiffness is introduced as a quenched random variable in the preferred shape index($p_0$) for each…

Biological Physics · Physics 2019-08-07 Xinzhi Li , Amit Das , Dapeng Bi

Flapping wings are the primary means by which dragonflies generate forces, but they are susceptible to damage due to their inherent fragility. The damage results in a reduction in wing area and a distortion of the original wing, which in…

Fluid Dynamics · Physics 2026-02-06 Peng Yu , Ramiro Godoy-Diana , Benjamin Thiria , Dmitry Kolomenskiy , Thomas Engels

Soft interfaces formed by lipid membranes are fundamental to living cells, synthetic cells, and membrane-based soft materials. However, a quantitative framework linking molecular organization with nonlinear interfacial mechanics remains…

Soft Condensed Matter · Physics 2026-01-27 Kazutoshi Masuda , Miho Yanagisawa

Segmentation in arthropod embryogenesis represents a well-known example of body plan diversity. Striped patterns of gene expression that lead to the future body segments appear simultaneously or sequentially in long and short germ-band…

Molecular Networks · Quantitative Biology 2008-07-31 Koichi Fujimoto , Shuji Ishihara , Kunihiko Kaneko

Networks of elastic beams can deform either by stretching or bending of their members. The primary mode of deformation (bending or stretching) crucially depends on the specific details of the network architecture. In order to shed light on…

Soft Condensed Matter · Physics 2016-09-23 Gérald Gurtner , Marc Durand

The evolution of various competing cell types in tissues, and the resulting persistent tissue population, is studied numerically and analytically in a particle-based model of active tissues. Mutations change the properties of cells in…

Populations and Evolution · Quantitative Biology 2024-06-03 Tobias Büscher , Nirmalendu Ganai , Gerhard Gompper , Jens Elgeti

Based on symmetry consideration of migration and shape deformations, we formulate phenomenologically the dynamics of cell crawling in two dimensions. Forces are introduced to change the cell shape. The shape deformations induce migration of…

Biological Physics · Physics 2016-03-23 Takao Ohta , Mitsusuke Tarama , Masaki Sano

Inspired by the unique textures of shark skin and bird flight feathers and tails, the convergent-divergent surface pattern holds promise in modulating boundary layer structures. This surface pattern exhibits protrusions precisely aligned…

Fluid Dynamics · Physics 2023-09-19 Arash Mohammadikarachi , Mustafa Z. Yousif , Bagus Nugroho , Hee-Chang Lim

Wind dispersal of seeds is one essential mechanisms for plants to proliferate and to invade new territories. In this paper we present a methodology that combines 3D-printing, a minimal theoretical model and experiments to determine the…

Fluid Dynamics · Physics 2019-07-24 Richard A. Fauli , Jean Rabault , Andreas Carlson

In many insect species, the thoracic structure plays a crucial role in enabling flight. In the dipteran indirect flight mechanism, the thorax acts as a transmission link between the flight muscles and the wings, and it is often thought to…

Biological Physics · Physics 2023-07-20 Arion Pons , Illy Perl , Omri Ben-Dov , Roni Maya , Tsevi Beatus

Since the lipid raft model was developed at the end of the last century, it became clear that the specific molecular arrangements of phospholipid assemblies within a membrane have profound implications in a vast range of physiological…

Soft Condensed Matter · Physics 2024-04-19 Alexander P. Fellows , Ben John , Martin Wolf , Martin Thämer

Large-scale coarse-grained molecular dynamics simulations of inhomogeneous gel networks were performed to investigate abnormal butterfly patterns in two-dimensional scattering. The networks were diamond lattice-based with distributions in…

Soft Condensed Matter · Physics 2025-01-20 Katsumi Hagita , Takahiro Murashima

During the last two decades, ecological speciation has been a major research theme in evolutionary biology. Ecological speciation occurs when reproductive isolation between populations evolves as a result of niche differentiation.…

Populations and Evolution · Quantitative Biology 2019-10-24 Emmanuelle Jousselin , Marianne Elias

Flying insects are thought to achieve energy-efficient flapping flight by storing and releasing elastic energy in their muscles, tendons, and thorax. However, flight systems consisting elastic elements coupled to nonlinear, unsteady…

Biological Physics · Physics 2024-03-07 James Lynch , Ethan S. Wold , Jeff Gau , Simon Sponberg , Nick Gravish

The stochastic variations in the structural properties of thin fiber networks govern to a great extent their mechanical performance. To assess the influence of local structural variability on the local strain and mechanical response of the…

Materials Science · Physics 2021-10-12 Mossab Alzweighi , Rami Mansour , Jussi Lahti , Ulrich Hirn , Artem Kulachenko

Since its foundations, more than one hundred years ago, the field of structural biology has strived to understand and analyze the properties of molecules and their interactions by studying the structure that they take in 3D space. However,…

Biomolecules · Quantitative Biology 2023-02-27 Gabriele Corso

Aerial insects exhibit highly agile maneuvers such as sharp braking, saccades, and body flips under disturbance. In contrast, insect-scale aerial robots are limited to tracking non-aggressive trajectories with small body acceleration. This…

Robotics · Computer Science 2025-08-06 Yi-Hsuan Hsiao , Andrea Tagliabue , Owen Matteson , Suhan Kim , Tong Zhao , Jonathan P. How , YuFeng Chen
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