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Highly-optimized complex transport networks serve crucial functions in many man-made and natural systems such as power grids and plant or animal vasculature. Often, the relevant optimization functional is non-convex and characterized by…

Biological Physics · Physics 2016-09-23 Henrik Ronellenfitsch , Eleni Katifori

The analysis of biological networks encompasses a wide variety of fields from genomic research of protein-protein interaction networks, to the physiological study of biologically optimized tree-like vascular networks. It is certain that…

Tissues and Organs · Quantitative Biology 2023-01-19 Timothy L. Kline

We build an evolutionary scenario that explains how some crucial physiological constraints in the arterial network of mammals - i.e. hematocrit, vessels diameters and arterial pressure drops - could have been selected by evolution. We…

Biological Physics · Physics 2014-05-22 Baptiste Moreau , Benjamin Mauroy

Many tasks in machine learning and signal processing can be solved by minimizing a convex function of a measure. This includes sparse spikes deconvolution or training a neural network with a single hidden layer. For these problems, we study…

Optimization and Control · Mathematics 2018-10-30 Lenaic Chizat , Francis Bach

In this work, we introduce an algorithmic approach to generate microvascular networks starting from larger vessels that can be reconstructed without noticeable segmentation errors. Contrary to larger vessels, the reconstruction of…

Computational Engineering, Finance, and Science · Computer Science 2020-07-10 Tobias Köppl , Ettore Vidotto , Barbara Wohlmuth

Vascular networks are used across the kingdoms of life to transport fluids, nutrients and cellular material. A popular unifying idea for understanding the diversity and constraints of these networks is that the conduits making up the…

Optimization and Control · Mathematics 2017-09-13 Shyr-Shea Chang , Marcus Roper

Many foraging microorganisms rely upon cellular transport networks to deliver nutrients, fluid and organelles between different parts of the organism. Networked organisms ranging from filamentous fungi to slime molds demonstrate a…

Adaptation and Self-Organizing Systems · Physics 2020-12-08 Cassidy Mentus , Marcus Roper

Biological transport networks are highly optimized structures that ensure power-efficient distribution of fluids across various domains, including animal vasculature and plant venation. Theoretically, these networks can be described as…

Biological Physics · Physics 2025-08-01 Albert Alonso , Lars Erik J. Skjegstad , Julius B. Kirkegaard

We study the convergence of gradient flow for the training of deep neural networks. If Residual Neural Networks are a popular example of very deep architectures, their training constitutes a challenging optimization problem due notably to…

Machine Learning · Computer Science 2025-07-22 Raphaël Barboni , Gabriel Peyré , François-Xavier Vialard

Microvessels -blood vessels with diameter less than 200 microns- form large, intricate networks organized into arterioles, capillaries and venules. In these networks, the distribution of flow and pressure drop is a highly interlaced…

Tissues and Organs · Quantitative Biology 2017-08-02 Paola Causin , Francesca Malgaroli

As nutrients travel through microcirculation and are absorbed, their availability continuously decreases. However, a uniform nutrient distribution is critical, as it prevents tissue death in poorly supplied areas. How, then, do vascular…

Tissues and Organs · Quantitative Biology 2024-11-18 Georgios Gounaris , Mija Jovchevska , Miguel Ruiz Garcia , Eleni Katifori

In this paper, we are concerned with the simulation of blood flow in microvascular networks and the surrounding tissue. To reduce the computational complexity of this issue, the network structures are modeled by a one-dimensional graph,…

Numerical Analysis · Mathematics 2023-05-01 Ettore Vidotto , Timo Koch , Tobias Köppl , Rainer Helmig , Barbara Wohlmuth

Motivated by distributed statistical learning over uncertain communication networks, we study distributed stochastic optimization by networked nodes to cooperatively minimize a sum of convex cost functions. The network is modeled by a…

Systems and Control · Electrical Eng. & Systems 2025-01-03 Yan Chen , Alexander L. Fradkov , Keli Fu , Xiaozheng Fu , Tao Li

Flux of rigid or soft particles (such as drops, vesicles, red blood cells, etc.) in a channel is a complex function of particle concentration, which depends on the details of induced dissipation and suspension structure due to hydrodynamic…

This paper addresses a distributed optimization problem in a communication network where nodes are active sporadically. Each active node applies some learning method to control its action to maximize the global utility function, which is…

Optimization and Control · Mathematics 2021-04-20 Wenjie Li , Mohamad Assaad , Shiqi Zheng

Many networked systems such as electric networks, the brain, and social networks of opinion dynamics are known to obey conservation laws. Examples of this phenomenon include the Kirchoff laws in electric networks and opinion consensus in…

Machine Learning · Statistics 2022-06-16 Anirudh Rayas , Rajasekhar Anguluri , Gautam Dasarathy

Branching in vascular networks and in overall organismic form is one of the most common and ancient features of multicellular plants, fungi, and animals. By combining machine-learning techniques with new theory that relates vascular form to…

Transport networks are crucial for the functioning of natural and technological systems. We study a mathematical model of vascular network adaptation, where the network structure dynamically adjusts to changes in blood flow and pressure.…

Adaptation and Self-Organizing Systems · Physics 2023-06-01 Konstantin Klemm , Erik Andreas Martens

Many biological systems approach physical limits to their performance, motivating the idea that their behavior and underlying mechanisms could be determined by such optimality. Nevertheless, optimization as a predictive principle has only…

Biological Physics · Physics 2023-12-05 Thomas R Sokolowski , Thomas Gregor , William Bialek , Gašper Tkačik

Gradient networks can be used to model the dominant structure of complex networks. Previous works have focused on random gradient networks. Here we study gradient networks that minimize jamming on substrate networks with scale-free and…

Statistical Mechanics · Physics 2009-11-13 Natali Gulbahce
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