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Tensor-based representations are being increasingly used to represent complex data types such as imaging data, due to their appealing properties such as dimension reduction and the preservation of spatial information. Recently, there is a…

Methodology · Statistics 2023-12-15 Rongke Lyu , Marina Vannucci , Suprateek Kundu

Cognitive impairment detection through spontaneous speech is a promising avenue for early diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI), where timely intervention can significantly improve patient outcomes. The…

Sound · Computer Science 2025-02-19 Yifan Gao , Long Guo , Hong Liu

The primary motivation and application in this article come from brain imaging studies on cognitive impairment in elderly subjects with brain disorders. We propose a regularized Haar wavelet-based approach for the analysis of…

Applications · Statistics 2014-08-11 Xuejing Wang , Bin Nan , Ji Zhu , Robert Koeppe

Deep learning has shown significant potential in diagnosing neurodegenerative diseases from MRI data. However, most existing methods rely heavily on large volumes of labeled data and often yield representations that lack interpretability.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Fangqi Cheng , Yingying Zhao , Xiaochen Yang

Early and accurate diagnosis of Alzheimer Disease is critical for effective clinical intervention, particularly in distinguishing it from Mild Cognitive Impairment, a prodromal stage marked by subtle structural changes. In this study, we…

Image and Video Processing · Electrical Eng. & Systems 2025-10-08 Fahad Mostafa , Kannon Hossain , Hafiz Khan

Estimation and hypothesis tests for the covariance matrix in high dimensions is a challenging problem as the traditional multivariate asymptotic theory is no longer valid. When the dimension is larger than or increasing with the sample…

Methodology · Statistics 2020-11-18 Deepak Nag Ayyala , Santu Ghosh , Daniel F. Linder

This paper introduces a novel framework for estimation and inference in penalized M-estimators applied to robust high-dimensional linear regression models. Traditional methods for high-dimensional statistical inference, which predominantly…

Methodology · Statistics 2025-04-15 Dian Zheng , Lingzhou Xue

It is often of interest to make inference on an unknown function that is a local parameter of the data-generating mechanism, such as a density or regression function. Such estimands can typically only be estimated at a…

Methodology · Statistics 2021-05-17 Aaron Hudson , Marco Carone , Ali Shojaie

We propose a novel Generalized Zero-Shot learning (GZSL) method that is agnostic to both unseen images and unseen semantic vectors during training. Prior works in this context propose to map high-dimensional visual features to the semantic…

Computer Vision and Pattern Recognition · Computer Science 2019-04-10 Pengkai Zhu , Hanxiao Wang , Venkatesh Saligrama

High-dimensional data can be useful for causal inference by providing many confounders that may bolster the plausibility of the ignorability assumption. Propensity score methods are powerful tools for causal inference, are popular in health…

Methodology · Statistics 2017-10-10 Jacob Spertus , Sharon-Lise Normand

For large-scale testing with graph-associated data, we present an empirical Bayes mixture technique to score local false discovery rates. Compared to empirical Bayes procedures that ignore the graph, the proposed method gains power in…

Methodology · Statistics 2019-11-26 TIen Vo , Vamsi Ithapu , Vikas Singh , Michael A. Newton

Score diffusion methods can learn probability densities from samples. The score of the noise-corrupted density is estimated using a deep neural network, which is then used to iteratively transport a Gaussian white noise density to a target…

Computer Vision and Pattern Recognition · Computer Science 2024-10-16 Zahra Kadkhodaie , Stéphane Mallat , Eero P. Simoncelli

The method of instrumental variables provides a fundamental and practical tool for causal inference in many empirical studies where unmeasured confounding between the treatments and the outcome is present. Modern data such as the genetical…

Methodology · Statistics 2022-10-28 Ziang Niu , Yuwen Gu , Wei Li

Machine learning methods have shown large potential for the automatic early diagnosis of Alzheimer's Disease (AD). However, some machine learning methods based on imaging data have poor interpretability because it is usually unclear how…

Accurately discriminating progressive stages of Alzheimer's Disease (AD) is crucial for early diagnosis and prevention. It often involves multiple imaging modalities to understand the complex pathology of AD, however, acquiring a complete…

Image and Video Processing · Electrical Eng. & Systems 2025-03-06 Seunghun Baek , Jaeyoon Sim , Guorong Wu , Won Hwa Kim

The theory of statistical inference along with the strategy of divide-and-conquer for large- scale data analysis has recently attracted considerable interest due to great popularity of the MapReduce programming paradigm in the Apache Hadoop…

Methodology · Statistics 2017-09-14 Ling Zhou , Peter X. -K. Song

Research question: This study aims to find whether other neurostructural measurements could be added and combined with the state-of-the-art Alzheimer's imaging marker called MSSM to improve sensitivity to neurodegeneration in Alzheimer's…

Neurons and Cognition · Quantitative Biology 2024-09-24 Jinhee Jang , Geonwoo Baek , Ikbeom Jang

This article introduces a predictor-dependent joint modeling framework for network data obtained from multiple subjects over a shared set of nodes with spatial co-ordinates and spatially correlated nodal attributes. The framework is highly…

Majority of the current dimensionality reduction or retrieval techniques rely on embedding the learned feature representations onto a computable metric space. Once the learned features are mapped, a distance metric aids the bridging of gaps…

Computer Vision and Pattern Recognition · Computer Science 2018-10-17 Muhammad Kamran Janjua , Shah Nawaz , Alessandro Calefati , Ignazio Gallo

People have expectations about how colors map to concepts in visualizations, and they are better at interpreting visualizations that match their expectations. Traditionally, studies on these expectations (inferred mappings) distinguished…

Human-Computer Interaction · Computer Science 2022-09-08 Melissa A. Schoenlein , Johnny Campos , Kevin J. Lande , Laurent Lessard , Karen B. Schloss