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We present a simple, yet general, end-to-end deep neural network representation of the potential energy surface for atomic and molecular systems. This methodology, which we call Deep Potential, is "first-principle" based, in the sense that…

Computational Physics · Physics 2020-07-20 Jiequn Han , Linfeng Zhang , Roberto Car , Weinan E

We present a 3D finite element solver for the nonlinear Poisson-Nernst-Planck (PNP) equations for electrodiffusion, coupled to the Stokes system of fluid dynamics. The model serves as a building block for the simulation of macromolecule…

Computational Physics · Physics 2017-04-05 Gregor Mitscha-Baude , Andreas Buttinger-Kreuzhuber , Gerhard Tulzer , Clemens Heitzinger

A statistical thermodynamic development is given of a new implicit solvent model that avoids the traditional system size limitations of computer simulation of macromolecular solutions with periodic boundary conditions. This implicit solvent…

Chemical Physics · Physics 2009-10-31 Lawrence R. Pratt , Susan B. Rempe

A multiscale QM/classical approach is presented, that is able to model the optical properties of complex nanostructures composed of a molecular system adsorbed on metal nanoparticles. The latter are described by a combined…

Chemical Physics · Physics 2024-10-29 Pablo Grobas Illobre , Piero Lafiosca , Luca Bonatti , Tommaso Giovannini , Chiara Cappelli

The Immersed Boundary Method (IBM) is one of the popular one-fluid mixed Eulerian-Lagrangian methods to simulate motion of droplets. While the treatment of a moving complex boundary is an extremely time consuming and formidable task in a…

Computational Physics · Physics 2018-07-30 Chia Rui Ong , Hiroaki Miura

We develop an immersed boundary (IB) method for modeling flows around fixed or moving rigid bodies that is suitable for a broad range of Reynolds numbers, including steady Stokes flow. The spatio-temporal discretization of the fluid…

Numerical Analysis · Mathematics 2016-03-02 B. Kallemov , A. Pal Singh Bhalla , B. E. Griffith , A. Donev

We describe a three-stage procedure to analyze the dependence of Poisson Boltzmann calculations on the shape, size and geometry of the boundary between solute and solvent. Our study is carried out within the boundary element formalism, but…

Biological Physics · Physics 2007-11-27 P. Kar , Y. Wei , U. H. E. Hansmann , S. Hoefinger

We introduce a novel mesoscopic computational model based on a multiphase-multicomponent lattice Boltzmann method for the simulation of self-phoretic particles in the presence of liquid-liquid interfaces. Our model features fully resolved…

Soft Condensed Matter · Physics 2022-06-22 Lucas Palacios , Andrea Scagliarini , Ignacio Pagonabarraga

We present a new multi-fluid, multi-temperature plasma solver with adaptive Cartesian mesh (ACM) based on a full-Newton (non-linear, implicit) scheme for collisional low-temperature plasma. The particle transport is described using the…

Computational Physics · Physics 2020-08-19 Robert Arslanbekov , Vladimir Kolobov

Electrostatics is of paramount importance to chemistry, physics, biology, and medicine. The Poisson-Boltzmann (PB) theory is a primary model for electrostatic analysis. However, it is highly challenging to compute accurate PB electrostatic…

Chemical Physics · Physics 2023-12-20 Jiahui Chen , Yongjia Xu , Xin Yang , Zixuan Cang , Weihua Geng , Guo-Wei Wei

Several implicit (continuum) solvent models are considered: the Polarized Continuum Model (PCM), the Surface Generalized Born model (SGB), and the COnductor-like Screening model (COSMO) as well as their implementation in the form of the…

The Immersed Boundary (IB) method is a widely-used numerical methodology for the simulation of fluid-structure interaction problems. The IB method utilizes an Eulerian discretization for the fluid equations of motion while maintaining a…

Numerical Analysis · Mathematics 2012-10-09 Varun Shankar , Grady B. Wright , Aaron L. Fogelson , R. M. Kirby

The paper presents a new method for shape and topology optimization based on an efficient and scalable boundary integral formulation for elasticity. To optimize topology, our approach uses iterative extraction of isosurfaces of a…

Optimization and Control · Mathematics 2016-12-14 Igor Ostanin , Ivan Tsybulin , Mikhail Litsarev , Ivan Oseledets , Denis Zorin

The Poisson-Boltzmann (PB) implicit solvent model is a popular framework for studying the electrostatics of biomolecules immersed in water with dissolved salt. In this model the dielectric interface between the biomolecule and solvent is…

Computational Physics · Physics 2020-10-22 Leighton Wilson , Robert Krasny

We develop a numerical method for solving a free boundary problem which describes shape relaxation, by surface tension, of a long and thin bubble of an inviscid fluid trapped inside a viscous fluid in a Hele-Shaw cell. The method of…

Computational Physics · Physics 2007-05-23 Arkady Vilenkin , Baruch Meerson

Modeling the chemical, electric, and thermal transport as well as phase transitions and the accompanying mesoscale microstructure evolution within a material in an electronic device setting involves the solution of partial differential…

Numerical Analysis · Mathematics 2024-09-26 Xiaofeng Xu , Lian Zhang , Yin Shi , Long-Qing Chen , Jinchao Xu

A multi-scale framework was recently proposed for more realistic molecular dynamics simulations in continuum solvent models by coupling a molecular mechanics treatment of solute with a fluid mechanics treatment of solvent, where we…

Biological Physics · Physics 2018-01-17 Li Xiao , Ray Luo

The size-modified Poisson-Boltzmann (MPB) equation is an efficient implicit solvation model which also captures electrolytic solvent effects. It combines an account of the dielectric solvent response with a mean-field description of…

Materials Science · Physics 2016-06-30 Stefan Ringe , Harald Oberhofer , Christoph Hille , Sebastian Matera , Karsten Reuter

We show that classical molecular density functional theory (MDFT), here in the homogeneous reference fluid approximation in which the functional is inferred from the properties of the bulk solvent, is a powerful new tool to study, at a…

A unified framework to derive discrete time-marching schemes for coupling of immersed solid and elastic objects to the lattice Boltzmann method is presented. Based on operator splitting for the discrete Boltzmann equation, second-order…

Computational Physics · Physics 2017-01-04 Ulf D. Schiller