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The Poisson-Boltzmann equation offers an efficient way to study electrostatics in molecular settings. Its numerical solution with the boundary element method is widely used, as the complicated molecular surface is accurately represented by…

Numerical Analysis · Mathematics 2021-08-25 Stefan D. Search , Christopher D. Cooper , Elwin van't Wout

In this paper, we solve the linearized Poisson-Boltzmann equation, used to model the electric potential of macromolecules in a solvent. We derive a corrected trapezoidal rule with improved accuracy for a boundary integral formulation of the…

Numerical Analysis · Mathematics 2022-10-10 Federico Izzo , Yimin Zhong , Olof Runborg , Richard Tsai

In this paper, we present a parallel higher-order boundary integral method to solve the linear Poisson-Boltzmann (PB) equation. In our method, a well-posed boundary integral formulation is used to ensure the fast convergence of Krylov…

Numerical Analysis · Mathematics 2015-06-12 Weihua Geng

This review describes the theory and implementation of implicit solvation models based on continuum electrostatics. Within quantum chemistry this formalism is sometimes synonymous with the polarizable continuum model, a particular…

Chemical Physics · Physics 2022-03-15 John M. Herbert

An accurate force calculation with the Poisson-Boltzmann equation is challenging, as it requires the electric field on the molecular surface. Here, we present a calculation of the electric field on the solute-solvent interface that is exact…

Chemical Physics · Physics 2023-01-13 Ian Addison-Smith , Horacio V. Guzmán , Christopher D. Cooper

The ab-initio computational treatment of electrochemical systems requires an appropriate treatment of the solid/liquid interfaces. A fully quantum mechanical treatment of the interface is computationally demanding due to the large number of…

We present the theory and implementation of a Poisson-Boltzmann implicit solvation model for electrolyte solutions. This model can be combined with arbitrary electronic structure methods that provide an accurate charge density of the…

Computational Physics · Physics 2020-01-08 Christopher J. Stein , John M. Herbert , Martin Head-Gordon

We develop a computational method for modeling electrostatic interactions of arbitrarily-shaped, polarizable objects on colloidal length scales, including colloids/nanoparticles, polymers, and surfactants, dispersed in explicit ion…

Soft Condensed Matter · Physics 2024-06-18 Emily Krucker-Velasquez , James W. Swan , Zachary Sherman

The Poisson--Boltzmann equation is widely used to model electrostatics in molecular systems. Available software packages solve it using finite difference, finite element, and boundary element methods, where the latter is attractive due to…

Computational Physics · Physics 2025-12-24 Michal Bosy , Matthew W. Scroggs , Timo Betcke , Erik Burman , Christopher D. Cooper

The computational study of chemical reactions in complex, wet environments is critical for applications in many fields. It is often essential to study chemical reactions in the presence of applied electrochemical potentials, taking into…

Materials Science · Physics 2016-01-20 G. Fisicaro , L. Genovese , O. Andreussi , N. Marzari , S. Goedecker

The electrostatic potential in the neighborhood of a biomolecule can be computed thanks to the non-linear divergence-form elliptic Poisson-Boltzmann PDE. Dedicated Monte-Carlo methods have been developed to solve its linearized version (see…

Numerical Analysis · Mathematics 2016-11-15 Mireille Bossy , Nicolas Champagnat , Helene Leman , Sylvain Maire , Laurent Violeau , Mariette Yvinec

The Poisson-Boltzmann model is an effective and popular approach for modeling solvated biomolecules in continuum solvent with dissolved electrolytes. In this paper, we report our recent work in developing a Galerkin boundary integral method…

Computational Physics · Physics 2021-10-27 Jiahui Chen , Johannes Tausch , Weihua Geng

Implicit solvent models, such as Poisson-Boltzmann models, play important roles in computational studies of biomolecules. A vital step in almost all implicit solvent models is to determine the solvent-solute interface, and the solvent…

Biological Physics · Physics 2021-05-20 Haixin Wei , Zekai Zhao , Ray Luo

Implicit solvation is an effective, highly coarse-grained approach in atomic-scale simulations to account for a surrounding liquid electrolyte on the level of a continuous polarizable medium. Originating in molecular chemistry with finite…

Chemical Physics · Physics 2021-08-06 Stefan Ringe , Nicolas G. Hörmann , Harald Oberhofer , Karsten Reuter

Solid-liquid interfaces are at the heart of many modern-day technologies and provide a challenge to many materials simulation methods. A realistic first-principles computational study of such systems entails the inclusion of solvent…

Accurate calculation of electrostatic potential and gradient on the molecular surface is highly desirable for the continuum and hybrid modeling of large scale deformation of biomolecules in solvent. In this article a new numerical method is…

Computational Physics · Physics 2020-08-26 George Borleske , Y. C. Zhou

In this article we show how to compute a matrix representation and the implicit equation by means of the method developed in [Botbol: arXiv:1007.3437], using the computer algebra system Macaulay2 \cite{M2}. As it is probably the most…

Algebraic Geometry · Mathematics 2010-07-22 Nicolas Botbol

Computational modeling and simulation of fluid-structure interactions constitute a fundamental cornerstone for advancing aerospace engineering endeavors. This paper addresses the notion and implementation of the immersed boundary method for…

Computational Physics · Physics 2025-12-24 Longqing Ge , Qingdong Cai , Yonghao Zhang , Tianbai Xiao

We have developed a new embedding method for solving scalar hyperbolic conservation laws on surfaces. The approach represents the interface implicitly by a signed distance function following the typical level set method and some embedding…

Numerical Analysis · Mathematics 2023-07-17 Chun Kit Hung , Shingyu Leung

In this paper we develop a methodology for the mesoscale simulation of strong electrolytes. The methodology is an extension of the Fluctuating Immersed Boundary (FIB) approach that treats a solute as discrete Lagrangian particles that…

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