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Sequencing by synthesis is the underlying technology for many next-generation DNA sequencing platforms. We developed a new model, the fixed flow cycle model, to derive the distributions of sequence length for a given number of flow cycles…

Genomics · Quantitative Biology 2024-05-28 Yong Kong

A new robust class of multivariate skew distributions is introduced. Practical aspects such as parameter estimation method of the proposed class are discussed, we show that the proposed class can be fitted under a reasonable time frame. Our…

Methodology · Statistics 2020-11-17 H. Kwong , S. Nadarajah

The transition density of a diffusion process does not admit an explicit expression in general, which prevents the full maximum likelihood estimation (MLE) based on discretely observed sample paths. A\"{\i}t-Sahalia [J. Finance 54 (1999)…

Statistics Theory · Mathematics 2012-03-12 Jinyuan Chang , Song Xi Chen

Topp-Leone distribution is a continuous model distribution used for modelling lifetime phenomena. The main purpose of this paper is to introduce a new framework for generating lifetime distributions, called the Topp-Leone generated…

Statistics Theory · Mathematics 2019-03-19 Nicy Sebastian , Rasin R. S. , Silviya P. O

Multitype branching processes are ideal for studying the population dynamics of stem cell populations undergoing mutation accumulation over the years following transplant. In such stochastic models, several quantities are of clinical…

Populations and Evolution · Quantitative Biology 2021-11-17 Timothy C Stutz , Janet S. Sinsheimer , Mary Sehl , Jason Xu

Handling missing values plays an important role in the analysis of survival data, especially, the ones marked by cure fraction. In this paper, we discuss the properties and implementation of stochastic approximations to the…

Methodology · Statistics 2021-07-22 Sandip Barui , Suvra Pal , Nutan Mishra , Katherine Davies

Finite mixture distributions arise in sampling a heterogeneous population. Data drawn from such a population will exhibit extra variability relative to any single subpopulation. Statistical models based on finite mixtures can assist in the…

Methodology · Statistics 2024-01-19 Andrew M. Raim , Nagaraj K. Neerchal , Jorge G. Morel

Models have been proposed to extract temporal patterns from longitudinal electronic health records (EHR) for clinical predictive models. However, the common relations among patients (e.g., receiving the same medical treatments) were rarely…

Applications · Statistics 2019-09-27 Yue Wang , Tong Wu , Yunlong Wang , Gao Wang

Given a distribution $\rho$ on persistence diagrams and observations $X_1,...X_n \stackrel{iid}{\sim} \rho$ we introduce an algorithm in this paper that estimates a Fr\'echet mean from the set of diagrams $X_1,...X_n$. If the underlying…

Statistics Theory · Mathematics 2013-03-21 Katharine Turner , Yuriy Mileyko , Sayan Mukherjee , John Harer

Linear regression is widely used to model relationships between responses and predictors. In modern applications, one encounters data where the responses are non-Euclidean random objects situated in a metric space, paired with Euclidean…

Methodology · Statistics 2026-05-20 Wookyeong Song , Paromita Dubey , Hans-Georg Müller , Alexander Petersen

A new three-parameter cumulative distribution function defined on $(\alpha,\infty)$, for some $\alpha\geq0$, with asymmetric probability density function and showing exponential decays at its both tails, is introduced. The new distribution…

Statistics Theory · Mathematics 2017-03-28 Meitner Cadena

In applied research, Lee (2009) bounds are widely applied to bound the average treatment effect in the presence of selection bias. This paper extends the methodology of Lee bounds to accommodate outcomes in a general metric space, such as…

Econometrics · Economics 2026-01-15 Daisuke Kurisu , Yuta Okamoto , Taisuke Otsu

Analyzing electronic health records (EHR) poses significant challenges because often few samples are available describing a patient's health and, when available, their information content is highly diverse. The problem we consider is how to…

Machine Learning · Statistics 2019-12-20 Alexis Bellot , Mihaela van der Schaar

The mean residual life function is a key functional for a survival distribution. It has a practically useful interpretation as the expected remaining lifetime given survival up to a particular time point, and it also characterizes the…

Methodology · Statistics 2018-10-11 Valerie Poynor , Athanasios Kottas

The likelihood ratio test (LRT) is widely used for comparing the relative fit of nested latent variable models. Following Wilks' theorem, the LRT is conducted by comparing the LRT statistic with its asymptotic distribution under the…

Statistics Theory · Mathematics 2025-01-08 Yunxiao Chen , Irini Moustaki , Haoran Zhang

In this paper introduces a new family of continuous distributions namely the Poison transmuted-G family of distribution is proposed by inducing two addition parameter on the base line G distribution. Some of its mathematical properties…

Statistics Theory · Mathematics 2020-05-12 Laba Handique , Subrata Chakraborty

This paper primarily addresses a dataset relating to cellular, chemical and physical conditions of patients gathered at the time they are operated upon to remove colorectal tumours. This data provides a unique insight into the biochemical…

Machine Learning · Computer Science 2016-11-17 Christopher Roadknight , Durga Suryanarayanan , Uwe Aickelin , John Scholefield , Lindy Durrant

A multistate cure model is a statistical framework used to analyze and represent the transitions individuals undergo between different states over time, accounting for the possibility of being cured by initial treatment. This model is…

Methodology · Statistics 2024-12-02 Yilin Jiang , Harm van Tinteren , Marta Fiocco

Some new survival distributions are introduced based on a generalised exponential function. This class of distributions includes heavy-tailed generalisations of exponential, Weibull and gamma distributions. Properties of the distributions…

Methodology · Statistics 2014-12-03 Rose Baker

Transfer learning is beneficial for survival analysis, especially when the target study has a limited number of events. However, existing transfer learning methods rely on the restrictive assumption that the target and source studies share…

Methodology · Statistics 2026-03-13 Yu Gu , Donglin Zeng , D. Y. Lin