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Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is…

Molecular Networks · Quantitative Biology 2007-05-23 Gabriele Scheler

We propose that in order to harness our understanding of neuroscience toward machine learning, we must first have powerful tools for training brain-like models of learning. Although substantial progress has been made toward understanding…

Neural and Evolutionary Computing · Computer Science 2022-06-29 Samuel Schmidgall , Joe Hays

Learning is based on synaptic plasticity, which affects and is driven by neural activity. Because pre- and postsynaptic spiking activity is shaped by randomness, the synaptic weights follow a stochastic process, requiring a probabilistic…

Neurons and Cognition · Quantitative Biology 2026-01-14 Jakob Stubenrauch , Naomi Auer , Richard Kempter , Benjamin Lindner

We investigate cortical learning from the perspective of mechanism design. First, we show that discretizing standard models of neurons and synaptic plasticity leads to rational agents maximizing simple scoring rules. Second, our main result…

Artificial Intelligence · Computer Science 2014-01-08 David Balduzzi

The ability of responding to environmental stimuli with appropriate actions is a property shared by all living organisms, and it is also sought in the design of robotic systems. Phenotypic plasticity provides a way for achieving this…

Robotics · Computer Science 2020-06-04 Michele Braccini , Andrea Roli , Stuart A. Kauffman

Precise spatio-temporal patterns of neuronal action potentials underly e.g. sensory representations and control of muscle activities. However, it is not known how the synaptic efficacies in the neuronal networks of the brain adapt such that…

Neurons and Cognition · Quantitative Biology 2015-02-24 Christian Albers , Maren Westkott , Klaus Pawelzik

Artificial neural networks can be used to solve a variety of robotic tasks. However, they risk failing catastrophically when faced with out-of-distribution (OOD) situations. Several approaches have employed a type of synaptic plasticity…

The brain is formed by cortical regions that are associated with different cognitive functions. Neurons within the same region are more likely to connect than neurons in distinct regions, making the brain network to have characteristics of…

Neurons and Cognition · Quantitative Biology 2023-05-17 P. R. Protachevicz , F. S. Borges , A. M. Batista , M. S. Baptista , I. L. Caldas , E. E. N. Macau , E. L. Lameu

Brain plasticity refers to brain's ability to change neuronal connections, as a result of environmental stimuli, new experiences, or damage. In this work, we study the effects of the synaptic delay on both the coupling strengths and…

Neurons and Cognition · Quantitative Biology 2018-11-14 E. L. Lameu , E. E. N. Macau , F. S. Borges , K. C. Iarosz , I. L. Caldas , R. R. Borges , P. R. Protachevicz , R. L. Viana , A. M. Batista

Deep neural networks have excelled on a wide range of problems, from vision to language and game playing. Neural networks very gradually incorporate information into weights as they process data, requiring very low learning rates. If the…

The impressive lifelong learning in animal brains is primarily enabled by plastic changes in synaptic connectivity. Importantly, these changes are not passive, but are actively controlled by neuromodulation, which is itself under the…

Neural and Evolutionary Computing · Computer Science 2021-07-06 Thomas Miconi , Aditya Rawal , Jeff Clune , Kenneth O. Stanley

Synaptic plasticity depends on the interaction between electrical activity in neurons and the synaptic proteome, the collection of over 1000 proteins in the post-synaptic density (PSD) of synapses. To construct models of synaptic plasticity…

Neurons and Cognition · Quantitative Biology 2014-11-19 David C. Sterratt , Oksana Sorokina , J. Douglas Armstrong

Recurrent spiking neural networks (RSNN) in the human brain learn to perform a wide range of perceptual, cognitive and motor tasks very efficiently in terms of energy consumption and requires very few examples. This motivates the search for…

Neurons and Cognition · Quantitative Biology 2021-03-22 Paolo Muratore , Cristiano Capone , Pier Stanislao Paolucci

Plasticity, the ability of a neural network to quickly change its predictions in response to new information, is essential for the adaptability and robustness of deep reinforcement learning systems. Deep neural networks are known to lose…

Machine Learning · Computer Science 2023-11-28 Clare Lyle , Zeyu Zheng , Evgenii Nikishin , Bernardo Avila Pires , Razvan Pascanu , Will Dabney

For four decades statistical physics has been providing a framework to analyse neural networks. A long-standing question remained on its capacity to tackle deep learning models capturing rich feature learning effects, thus going beyond the…

Machine Learning · Statistics 2025-12-15 Jean Barbier , Francesco Camilli , Minh-Toan Nguyen , Mauro Pastore , Rudy Skerk

We study the learning of an external signal by a neural network and the time to forget it when this network is submitted to noise. The presentation of an external stimulus to the recurrent network of binary neurons may change the state of…

Probability · Mathematics 2020-06-11 Pascal Helson

In this work, we propose a distributed adaptive observer for a class of nonlinear networked systems inspired by biophysical neural network models. Neural systems learn by adjusting intrinsic and synaptic weights in a distributed fashion,…

Systems and Control · Electrical Eng. & Systems 2022-09-22 Thiago B. Burghi , Timothy O'Leary , Rodolphe Sepulchre

Animals (especially humans) have an amazing ability to learn new tasks quickly, and switch between them flexibly. How brains support this ability is largely unknown, both neuroscientifically and algorithmically. One reasonable supposition…

Machine Learning · Computer Science 2017-06-23 Kevin T. Feigelis , Daniel L. K. Yamins

Short-term synaptic plasticity (STP) is often regarded as a presynaptic filter of spikes, independent of postsynaptic activity. Recent experiments, however, indicate an associative STP that depends on pre- and postsynaptic coactivation. We…

Neurons and Cognition · Quantitative Biology 2026-05-20 Genki Shimizu , Taro Toyoizumi

As a means of dynamically reconfiguring the synaptic weight of a superconducting optoelectronic loop neuron, a superconducting flux storage loop is inductively coupled to the synaptic current bias of the neuron. A standard flux memory cell…

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