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Tractography fiber clustering using diffusion MRI (dMRI) is a crucial strategy for white matter (WM) parcellation. Current methods primarily use the geometric information of fibers (i.e., the spatial trajectories) to group similar fibers…

Image and Video Processing · Electrical Eng. & Systems 2024-12-17 Jin Wang , Bocheng Guo , Yijie Li , Junyi Wang , Yuqian Chen , Jarrett Rushmore , Nikos Makris , Yogesh Rathi , Lauren J O'Donnell , Fan Zhang

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial method for white matter (WM) parcellation to enable analysis of brains structural connectivity in health and disease. Current fiber clustering strategies primarily use…

Image and Video Processing · Electrical Eng. & Systems 2025-11-04 Bocheng Guo , Jin Wang , Yijie Li , Junyi Wang , Mingyu Gao , Puming Feng , Yuqian Chen , Jarrett Rushmore , Nikos Makris , Yogesh Rathi , Lauren J O'Donnell , Fan Zhang

Diffusion magnetic resonance imaging, a non-invasive tool to infer white matter fiber connections, produces a large number of streamlines containing a wealth of information on structural connectivity. The size of these tractography outputs…

Computer Vision and Pattern Recognition · Computer Science 2018-04-17 Kuldeep Kumar , Kaleem Siddiqi , Christian Desrosiers

White matter fiber clustering (WMFC) enables parcellation of white matter tractography for applications such as disease classification and anatomical tract segmentation. However, the lack of ground truth and the ambiguity of fiber data (the…

Computer Vision and Pattern Recognition · Computer Science 2021-07-13 Yuqian Chen , Chaoyi Zhang , Yang Song , Nikos Makris , Yogesh Rathi , Weidong Cai , Fan Zhang , Lauren J. O'Donnell

White matter fiber clustering is an important strategy for white matter parcellation, which enables quantitative analysis of brain connections in health and disease. In combination with expert neuroanatomical labeling, data-driven white…

Computer Vision and Pattern Recognition · Computer Science 2023-07-11 Yuqian Chen , Chaoyi Zhang , Tengfei Xue , Yang Song , Nikos Makris , Yogesh Rathi , Weidong Cai , Fan Zhang , Lauren J. O'Donnell

The white matter of the brain is organised into axonal bundles that support long-range neural communication. Although diffusion MRI (dMRI) enables detailed mapping of these pathways through tractography, how white matter pathways directly…

Neurons and Cognition · Quantitative Biology 2026-02-24 Yifei Sun , James M. Shine , Robert D. Sanders , Robin F. H. Cash , Sharon L. Naismith , Fernando Calamante , Jinglei Lv

Parcellation of white matter tractography provides anatomical features for disease prediction, anatomical tract segmentation, surgical brain mapping, and non-imaging phenotype classifications. However, parcellation does not always reach…

Computer Vision and Pattern Recognition · Computer Science 2024-09-23 Yui Lo , Yuqian Chen , Fan Zhang , Dongnan Liu , Leo Zekelman , Suheyla Cetin-Karayumak , Yogesh Rathi , Weidong Cai , Lauren J. O'Donnell

We present the concept of fiber-flux density for locally quantifying white matter (WM) fiber bundles. By combining scalar diffusivity measures (e.g., fractional anisotropy) with fiber-flux measurements, we define new local descriptors…

Computer Vision and Pattern Recognition · Computer Science 2017-09-20 Itay Benou , Ronel Veksler , Alon Friedman , Tammy Riklin Raviv

Diffusion-weighted magnetic resonance imaging allows for reconstruction of models for structural connectivity in the brain, such as fiber orientation distribution functions (ODFs) that describe the distribution, direction, and volume of…

The brain white matter consists of a set of tracts that connect distinct regions of the brain. Segmentation of these tracts is often needed for clinical and research studies. Diffusion-weighted MRI offers unique contrast to delineate these…

Image and Video Processing · Electrical Eng. & Systems 2023-07-06 Hamza Kebiri , Ali Gholipour , Meritxell Bach Cuadra , Davood Karimi

We propose a novel and efficient algorithm to model high-level topological structures of neuronal fibers. Tractography constructs complex neuronal fibers in three dimensions that exhibit the geometry of white matter pathways in the brain.…

Computer Vision and Pattern Recognition · Computer Science 2021-08-04 S. Shailja , Angela Zhang , B. S. Manjunath

Tractography from high-dimensional diffusion magnetic resonance imaging (dMRI) data allows brain's structural connectivity analysis. Recent dMRI studies aim to compare connectivity patterns across subject groups and disease populations to…

Diffusion tensor imaging provides important information on tissue structure and orientation of fiber tracts in brain white matter in vivo. It results in diffusion tensors, which are $3\times3$ symmetric positive definite (SPD) matrices,…

Applications · Statistics 2013-04-17 Ying Yuan , Hongtu Zhu , Martin Styner , John H. Gilmore , J. S. Marron

The shape of the brain's white matter connections is relatively unexplored in diffusion MRI tractography analysis. While it is known that tract shape varies in populations and across the human lifespan, it is unknown if the variability in…

Neuroimaging measures of the brain's white matter connections can enable the prediction of non-imaging phenotypes, such as demographic and cognitive measures. Existing works have investigated traditional microstructure and connectivity…

Computer Vision and Pattern Recognition · Computer Science 2023-05-23 Wan Liu , Yuqian Chen , Chuyang Ye , Nikos Makris , Yogesh Rathi , Weidong Cai , Fan Zhang , Lauren J. O'Donnell

The segregation of brain fiber tractography data into distinct and anatomically meaningful clusters can help to comprehend the complex brain structure and early investigation and management of various neural disorders. We propose a novel…

Computer Vision and Pattern Recognition · Computer Science 2017-10-17 Tushar Gupta , Shreyas Malakarjun Patil , Mukkaram Tailor , Daksh Thapar , Aditya Nigam

Fiber tractography on diffusion imaging data offers rich potential for describing white matter pathways in the human brain, but characterizing the spatial organization in these large and complex data sets remains a challenge. We show that…

Methodology · Statistics 2015-06-18 Brian P. Kent , Alessandro Rinaldo , Fang-Cheng Yeh , Timothy Verstynen

White matter tract microstructure has been shown to influence neuropsychological scores of cognitive performance. However, prediction of these scores from white matter tract data has not been attempted. In this paper, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2022-07-07 Yuqian Chen , Fan Zhang , Chaoyi Zhang , Tengfei Xue , Leo R. Zekelman , Jianzhong He , Yang Song , Nikos Makris , Yogesh Rathi , Alexandra J. Golby , Weidong Cai , Lauren J. O'Donnell

Fiber tracking based on diffusion weighted Magnetic Resonance Imaging (dMRI) allows for noninvasive reconstruction of fiber bundles in the human brain. In this chapter, we discuss sources of error and uncertainty in this technique, and…

Computer Vision and Pattern Recognition · Computer Science 2013-07-15 Thomas Schultz , Anna Vilanova , Ralph Brecheisen , Gordon Kindlmann

Cortical thickness measurements from magnetic resonance imaging, an important biomarker in many neurodegenerative and neurological disorders, are derived by many tools from an initial voxel-wise tissue segmentation. White matter (WM)…

Image and Video Processing · Electrical Eng. & Systems 2025-03-27 Vinzenz Uhr , Ivan Diaz , Christian Rummel , Richard McKinley
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