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Collecting genomics data across multiple heterogeneous populations (e.g., across different cancer types) has the potential to improve our understanding of disease. Despite sequencing advances, though, resources often remain a constraint…

Methodology · Statistics 2024-03-05 Yunyi Shen , Lorenzo Masoero , Joshua G. Schraiber , Tamara Broderick

Using a bit-string model of evolution, we find a successful route to diploidy and sex in simple organisms. Allowing the sexually reproducing diploid individuals to also perform mitosis, as they do in a haploid-diploid cycle, leads to the…

Soft Condensed Matter · Physics 2007-05-23 Erkan Tuzel , Volkan Sevim , Ayse Erzan

Gene gain-loss-duplication models are commonly based on continuous-time birth-death processes. Employed in a phylogenetic context, such models have been increasingly popular in studies of gene content evolution across multiple genomes.…

Populations and Evolution · Quantitative Biology 2021-07-27 Miklos Csuros

We reconsider the deterministic haploid mutation-selection equation with two types. This is an ordinary differential equation that describes the type distribution (forward in time) in a population of infinite size. This paper establishes…

Probability · Mathematics 2020-09-25 Ellen Baake , Fernando Cordero , Sebastian Hummel

We consider two versions of stochastic population models with mutation and selection. The first approach relies on a multitype branching process; here, individuals reproduce and change type (i.e., mutate) independently of each other,…

Populations and Evolution · Quantitative Biology 2009-02-19 E. Baake , R. Bialowons

In an earlier paper, we introduced and studied a system of hierarchically interacting measure-valued random processes which describes a large population of individuals carrying types and living in colonies labelled by the hierarchical group…

Probability · Mathematics 2017-03-10 Andreas Greven , Frank den Hollander , Anton Klimovsky

For a family of models of evolving population under selection, which can be described by noisy traveling wave equations, the coalescence times along the genealogical tree scale like $\log^\alpha N$, where $N$ is the size of the population,…

Disordered Systems and Neural Networks · Physics 2007-05-23 E. Brunet , B. Derrida , A. H. Mueller , S. Munier

We study a universal object for the genealogy of a sample in populations with mutations: the critical birth-death process with Poissonian mutations, conditioned on its population size at a fixed time horizon. We show how this process arises…

Probability · Mathematics 2014-07-30 G. Achaz , C. Delaporte , A. Lambert

We consider a population of haploid individuals reproducing sexually, i.e. for which the genome of each individual is a random mixture of the genome of its two parents. We assume that initially one individual carries a mutation at one…

Probability · Mathematics 2022-10-06 Camille Coron , Yves Le Jan

We compare two different models of transport of light in a disordered system with a spherical Gaussian distribution of scatterers. A coupled dipole model, keeping into account all interference effects, is compared to an incoherent model,…

Coalescent histories are combinatorial structures that describe for a given gene tree and species tree the possible lists of branches of the species tree on which the gene tree coalescences take place. Properties of the number of coalescent…

Populations and Evolution · Quantitative Biology 2015-03-13 Filippo Disanto , Noah A. Rosenberg

Extending the previous 2-gender dioecious diploid gene-mating evolution model [arXiv:1410.3456], we attempt to answer "whether the Hardy-Weinberg global stability and the exact analytic dynamical solutions can be found in the generalized…

Populations and Evolution · Quantitative Biology 2020-07-22 Juven Wang

The Schelling model of segregation looks to explain the way in which a population of agents or particles of two types may come to organise itself into large homogeneous clusters, and can be seen as a variant of the Ising model in which the…

Discrete Mathematics · Computer Science 2015-08-13 George Barmpalias , Richard Elwes , Andy Lewis-Pye

We consider a stochastic model, called the replicator coalescent, describing a system of blocks of $k$ different types which undergo pairwise mergers at rates depending on the block types: with rate $C_{i,j}$ blocks of type $i$ and $j$…

Probability · Mathematics 2025-06-25 A. E. Kyprianou , L. Peñaloza , T. Rogers

We consider a neutral haploid population whose generations are not overlapping and whose size is large and constantly of $N$ individuals. Any generation is replaced by a new one and any individual has a single parent. We do not choose the…

Populations and Evolution · Quantitative Biology 2009-11-11 Maurizio Serva

Many population genetic models have been developed for the purpose of inferring population size and growth rates from random samples of genetic data. We examine two popular approaches to this problem, the coalescent and the…

Populations and Evolution · Quantitative Biology 2014-08-29 Erik M. Volz , Simon DW Frost

Consider a population where individuals give birth at constant rate during their lifetimes to i.i.d. copies of themselves. Individuals bear clonally inherited types, but (neutral) mutations may happen at the birth events. The smallest…

Probability · Mathematics 2013-05-29 Cécile Delaporte

We consider catalytic branching populations. They consist of a catalyst population evolving according to a critical binary branching process in continuous time with a constant branching rate and a reactant population with a branching rate…

Probability · Mathematics 2009-09-29 Andreas Greven , Lea Popovic , Anita Winter

Interacting particle systems undergoing repeated mutation and selection steps model genetic evolution, and also describe a broad class of sequential Monte Carlo methods. The genealogical tree embedded into the system is important in both…

Probability · Mathematics 2023-04-20 Suzie Brown , Paul A. Jenkins , Adam M. Johansen , Jere Koskela

We study the effect of biological confounders on the model selection problem between Kingman coalescents with population growth, and Xi-coalescents involving simultaneous multiple mergers. We use a low dimensional, computationally tractable…

Populations and Evolution · Quantitative Biology 2019-08-13 Jere Koskela , Maite Wilke Berenguer