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Alzheimer's disease is one of the most common types of neurodegenerative disease, characterized by the accumulation of amyloid-beta plaque and tau tangles. Recently, deep learning approaches have shown promise in Alzheimer's disease…

Image and Video Processing · Electrical Eng. & Systems 2024-07-03 Gia Minh Hoang , Youngjoo Lee , Jae Gwan Kim

Alzheimer's disease (AD) is a progressive neurodegenerative condition necessitating early and precise diagnosis to provide prompt clinical management. Given the paramount importance of early diagnosis, recent studies have increasingly…

Machine Learning · Computer Science 2026-02-18 Fatemeh Khalvandi , Saadat Izadi , Abdolah Chalechale

Brain-related diseases are more sensitive than other diseases due to several factors, including the complexity of surgical procedures, high costs, and other challenges. Alzheimer's disease is a common brain disorder that causes memory loss…

Image and Video Processing · Electrical Eng. & Systems 2024-03-11 Maleka Khatun , Md Manowarul Islam , Habibur Rahman Rifat , Md. Shamim Bin Shahid , Md. Alamin Talukder , Md Ashraf Uddin

Autism Spectrum Disorder(ASD) is a set of neurodevelopmental conditions that affect patients' social abilities. In recent years, many studies have employed deep learning to diagnose this brain dysfunction through functional MRI (fMRI).…

Image and Video Processing · Electrical Eng. & Systems 2021-10-26 Li Pan , Jundong Liu , Mingqin Shi , Chi Wah Wong , Kei Hang Katie Chan

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of…

Computer Vision and Pattern Recognition · Computer Science 2020-08-28 Wonsik Jung , Eunji Jun , Heung-Il Suk

Identifying and utilising various biomarkers for tracking Alzheimer's disease (AD) progression have received many recent attentions and enable helping clinicians make the prompt decisions. Traditional progression models focus on extracting…

Machine Learning · Computer Science 2023-11-08 Xulong Wang , Yu Zhang , Menghui Zhou , Tong Liu , Jun Qi , Po Yang

Understanding the interactions between biomarkers among brain regions during neurodegenerative disease is essential for unravelling the mechanisms underlying disease progression. For example, pathophysiological models of Alzheimer's Disease…

Artificial Intelligence · Computer Science 2025-11-17 Tiantian He , An Zhao , Elinor Thompson , Anna Schroder , Ahmed Abdulaal , Frederik Barkhof , Daniel C. Alexander

Normative modelling is an emerging method for understanding the underlying heterogeneity within brain disorders like Alzheimer Disease (AD) by quantifying how each patient deviates from the expected normative pattern that has been learned…

Image and Video Processing · Electrical Eng. & Systems 2026-02-06 Sayantan Kumar , Philip Payne , Aristeidis Sotiras

Alzheimer's disease (AD) persists as a paramount challenge in neurological research, characterized by the pathological hallmarks of amyloid-$\beta$ (A$\beta$) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. This…

Molecular Networks · Quantitative Biology 2025-12-05 She Xutong

Background and Objective: In brain imaging, geometric surface models are essential for analyzing the 3D shapes of anatomical structures. Alzheimer's disease (AD) is associated with significant cortical atrophy, making such shape analysis a…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 F. Ahmadi , B. Bidabad , H. Nasiri

Accurate and efficient classification of Alzheimer's disease (AD) severity from brain magnetic resonance imaging (MRI) remains a critical challenge, particularly when limited data and model interpretability are of concern. In this work, we…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Faisal Ahmed

Normative modeling has emerged as a pivotal approach for characterizing heterogeneity and individual variance in neurodegenerative diseases, notably Alzheimer's disease(AD). One of the challenges of cortical normative modeling is the…

Image and Video Processing · Electrical Eng. & Systems 2026-03-13 Jianwei Zhang , Yonggang Shi

Functional Connectivity between brain regions is known to be altered in Alzheimer's disease, and promises to be a biomarker for early diagnosis of the disease. While several approaches for functional connectivity obtain an un-directed…

Neurons and Cognition · Quantitative Biology 2024-02-21 Rahul Biswas , SuryaNarayana Sripada

Alzheimer's Disease (AD) is a neurodegenerative disease affecting millions of individuals across the globe. As the prevalence of this disease continues to rise, early diagnosis is crucial to improve clinical outcomes. Neural networks,…

Image and Video Processing · Electrical Eng. & Systems 2024-09-06 Akshay Sunkara , Rajiv Morthala , Anav Jain , Srinjoy Ghose , Santosh Morthala

Accurate predictions of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) can enable effective personalized therapy. While cognitive tests and clinical data are routinely collected, they lack the predictive power…

Machine Learning · Computer Science 2025-11-11 Richard Hou , Shengpu Tang , Wei Jin

\textbf{Objective:} Alzheimer's disease (AD) is the most prevalent form of dementia worldwide, encompassing a prodromal stage known as Mild Cognitive Impairment (MCI), where patients may either progress to AD or remain stable. The objective…

Purpose: This study investigates whether a machine-learning-based system can predict the rate of cognitive decline in mildly cognitively impaired patients by processing only the clinical and imaging data collected at the initial visit.…

Quantitative Methods · Quantitative Biology 2020-10-07 Sema Candemir , Xuan V. Nguyen , Luciano M. Prevedello , Matthew T. Bigelow , Richard D. White , Barbaros S. Erdal

In recent years, deep learning models have been applied to neuroimaging data for early diagnosis of Alzheimer's disease (AD). Structural magnetic resonance imaging (sMRI) and positron emission tomography (PET) images provide structural and…

Image and Video Processing · Electrical Eng. & Systems 2023-08-01 Yanteng Zhanga , Xiaohai He , Yi Hao Chan , Qizhi Teng , Jagath C. Rajapakse

Understanding the structure of the brain, and how it changes with time and disease, is a core goal of structural neuroimaging. Contemporary approaches to structural brain analysis are dominated by voxel-wise, mass-univariate methods such as…

Algebraic Topology · Mathematics 2026-04-28 Donato Quiccione , Mariam Pirashvili , Nathan Broomhead , Sean J. Fallon

Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to…