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The alignment of biological networks has the potential to teach us as much about biology and disease as has sequence alignment. Sequence alignment can be optimally solved in polynomial time. In contrast, network alignment is $NP$-hard,…

Molecular Networks · Quantitative Biology 2016-07-12 Nil Mamano , Wayne Hayes

Sequence alignment has had an enormous impact on our understanding of biology, evolution, and disease. The alignment of biological {\em networks} holds similar promise. Biological networks generally model interactions between biomolecules…

Molecular Networks · Quantitative Biology 2019-11-25 Wayne B. Hayes

Network alignment, in general, seeks to discover the hidden underlying correspondence between nodes across two (or more) networks when given their network structure. However, most existing network alignment methods have added assumptions of…

Social and Information Networks · Computer Science 2019-02-28 Tyler Derr , Hamid Karimi , Xiaorui Liu , Jiejun Xu , Jiliang Tang

Biological network alignment aims to identify similar regions between networks of different species. Existing methods compute node "similarities" to rapidly identify from possible alignments the "high-scoring" alignments with respect to the…

Molecular Networks · Quantitative Biology 2013-11-12 Vikram Saraph , Tijana Milenković

Biological network alignment (NA) aims to identify similar regions between molecular networks of different species. NA can be local or global. Just as the recent trend in the NA field, we also focus on global NA, which can be pairwise (PNA)…

Molecular Networks · Quantitative Biology 2020-04-28 Vipin Vijayan , Shawn Gu , Eric Krebs , Lei Meng , Tijana Milenkovic

The function of a protein is defined by its interaction partners. Thus, topology-driven network alignment of the protein-protein interaction (PPI) networks of two species should uncover similar interaction patterns and allow identification…

Molecular Networks · Quantitative Biology 2022-08-29 Siyue Wang , Xiaoyin Chen , Brent J. Frederisy , Benedict A. Mbakogu , Amy D. Kanne , Pasha Khosravi , Wayne B. Hayes

Sequence comparison and alignment has had an enormous impact on our understanding of evolution, biology, and disease. Comparison and alignment of biological networks will likely have a similar impact. Existing network alignments use…

Molecular Networks · Quantitative Biology 2009-10-08 Oleksii Kuchaiev , Tijana Milenkovic , Vesna Memisevic , Wayne Hayes , Natasa Przulj

Biological network alignment (NA) aims to find a node mapping between species' molecular networks that uncovers similar network regions, thus allowing for transfer of functional knowledge between the aligned nodes. However, current NA…

Molecular Networks · Quantitative Biology 2020-09-09 Shawn Gu , Tijana Milenkovic

Deep generative models have made significant advances in generating complex content, yet conditional generation remains a fundamental challenge. Existing conditional generative adversarial networks often struggle to balance the dual…

The experiments conducted in previous studies demonstrated the successful performance of BSA and its non-sensitivity toward the several types of optimisation problems. This success of BSA motivated researchers to work on expanding it, e.g.,…

Neural and Evolutionary Computing · Computer Science 2019-12-03 Bryar A. Hassan , Tarik A. Rashid

Network alignment (NA) aims to find regions of similarities between molecular networks of different species. There exist two NA categories: local (LNA) or global (GNA). LNA finds small highly conserved network regions and produces a…

Molecular Networks · Quantitative Biology 2015-09-30 Lei Meng , Aaron Striegel , Tijana Milenkovic

Network alignment (NA) aims to find a node mapping between molecular networks of different species that identifies topologically or functionally similar network regions. Analogous to genomic sequence alignment, NA can be used to transfer…

Molecular Networks · Quantitative Biology 2016-04-07 Vipin Vijayan , Tijana Milenkovic

There is a growing need to deploy machine learning for different tasks on a wide array of new hardware platforms. Such deployment scenarios require tackling multiple challenges, including identifying a model architecture that can achieve a…

Machine Learning · Computer Science 2022-08-26 Elias Jääsaari , Michelle Ma , Ameet Talwalkar , Tianqi Chen

Algorithmic Bias can be due to bias in the training data or issues with the algorithm itself. These algorithmic issues typically relate to problems with model capacity and regularisation. This underestimation bias may arise because the…

Machine Learning · Computer Science 2021-06-01 William Blanzeisky , Pádraig Cunningham

Neural architecture search (NAS) can have a significant impact in computer vision by automatically designing optimal neural network architectures for various tasks. A variant, binarized neural architecture search (BNAS), with a search space…

Computer Vision and Pattern Recognition · Computer Science 2020-02-12 Hanlin Chen , Li'an Zhuo , Baochang Zhang , Xiawu Zheng , Jianzhuang Liu , David Doermann , Rongrong Ji

We propose a modified MSA algorithm on quantum annealers with applications in areas of bioinformatics and genetic sequencing. To understand the human genome, researchers compare extensive sets of these genetic sequences -- or their protein…

Quantum Physics · Physics 2024-03-28 Melody Lee

Active learning (AL) algorithms may achieve better performance with fewer data because the model guides the data selection process. While many algorithms have been proposed, there is little study on what the optimal AL algorithm looks like,…

Machine Learning · Computer Science 2021-02-23 Yilun Zhou , Adithya Renduchintala , Xian Li , Sida Wang , Yashar Mehdad , Asish Ghoshal

Science and Engineering applications are typically associated with expensive optimization problems to identify optimal design solutions and states of the system of interest. Bayesian optimization and active learning compute surrogate models…

Machine Learning · Computer Science 2024-07-09 Francesco Di Fiore , Michela Nardelli , Laura Mainini

In engineering optimization problems, multiple objectives with a large number of variables under highly nonlinear constraints are usually required to be simultaneously optimized. Significant computing effort are required to find the Pareto…

Neural and Evolutionary Computing · Computer Science 2020-08-06 Junfei Zhang , Yimiao Huang , Guowei Ma , Brett Nener

Complex networks are frequently employed to model physical or virtual complex systems. When certain entities exist across multiple systems simultaneously, unveiling their corresponding relationships across the networks becomes crucial. This…

Physics and Society · Physics 2025-04-16 Rui Tang , Ziyun Yong , Shuyu Jiang , Xingshu Chen , Yaofang Liu , Yi-Cheng Zhang , Gui-Quan Sun , Wei Wang
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