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We consider the optimal strategy for laboratory testing of biological samples when we wish to know the results for each sample rather than the average prevalence of positive samples. If the proportion of positive samples is low considerable…

Quantitative Methods · Quantitative Biology 2010-07-29 Brian G. Williams

Hypothesis testing is a statistical inference approach used to determine whether data supports a specific hypothesis. An important type is the two-sample test, which evaluates whether two sets of data points are from identical…

Machine Learning · Computer Science 2025-01-08 Weizhi Li , Visar Berisha , Gautam Dasarathy

Neuroimaging datasets keep growing in size to address increasingly complex medical questions. However, even the largest datasets today alone are too small for training complex machine learning models. A potential solution is to increase…

Machine Learning · Computer Science 2019-07-10 Christian Wachinger , Benjamin Gutierrez Becker , Anna Rieckmann , Sebastian Pölsterl

Longitudinal cohort studies, which follow a group of individuals over time, provide the opportunity to examine causal effects of complex exposures on long-term health outcomes. Utilizing data from multiple cohorts has the potential to add…

Pooled testing offers an efficient solution to the unprecedented testing demands of the COVID-19 pandemic, although with potentially lower sensitivity and increased costs to implementation in some settings. Assessments of this trade-off…

Applications · Statistics 2021-07-13 Saskia Comess , Hannah Wang , Susan Holmes , Claire Donnat

Two-sample hypothesis testing for network comparison presents many significant challenges, including: leveraging repeated network observations and known node registration, but without requiring them to operate; relaxing strong structural…

Methodology · Statistics 2024-02-05 Meijia Shao , Dong Xia , Yuan Zhang , Qiong Wu , Shuo Chen

This paper presents a hypothesis testing method given independent samples from a number of connected populations. The method is motivated by a forestry project for monitoring change in the strength of lumber. Traditional practice has been…

Statistics Theory · Mathematics 2015-05-15 Song Cai , Jiahua Chen , James V. Zidek

Hypothesis testing in high dimensional data is a notoriously difficult problem without direct access to competing models' likelihood functions. This paper argues that statistical divergences can be used to quantify the difference between…

Data Analysis, Statistics and Probability · Physics 2024-08-02 Jeremy J. H. Wilkinson , Christopher G. Lester

In observational studies, researchers must select a method to control for confounding. Options include propensity score methods and regression. It remains unclear how dataset characteristics (size, overlap in propensity scores, exposure…

Methodology · Statistics 2022-10-21 J. Wilkinson , M. A. Mamas , E. Kontopantelis

This paper presents a simple, effective, and cost-efficient strategy to improve LLM performance by scaling test-time compute. Our strategy builds upon the repeated-sampling-then-voting framework, with a novel twist: incorporating multiple…

Artificial Intelligence · Computer Science 2025-11-11 Jianhao Chen , Zishuo Xun , Bocheng Zhou , Han Qi , Hangfan Zhang , Qiaosheng Zhang , Yang Chen , Wei Hu , Yuzhong Qu , Wanli Ouyang , Shuyue Hu

Network datasets appear across a wide range of scientific fields, including biology, physics, and the social sciences. To enable data-driven discoveries from these networks, statistical inference techniques like estimation and hypothesis…

Methodology · Statistics 2026-02-19 Arpan Kumar , Minh Tang , Srijan Sengupta

Meta-analysis is routinely performed in many scientific disciplines. This analysis is attractive since discoveries are possible even when all the individual studies are underpowered. However, the meta-analytic discoveries may be entirely…

Methodology · Statistics 2023-05-09 Marina Bogomolov , Ruth Heller

Applied researchers often find themselves making statistical inferences in settings that would seem to require multiple comparisons adjustments. We challenge the Type I error paradigm that underlies these corrections. Moreover we posit that…

Applications · Statistics 2009-07-16 Andrew Gelman , Jennifer Hill , Masanao Yajima

Realignment is a promising strategy to improve cross-lingual transfer in multilingual language models. However, empirical results are mixed and often unreliable, particularly for typologically distant or low-resource languages (LRLs)…

Computation and Language · Computer Science 2025-11-11 Quang Phuoc Nguyen , David Anugraha , Felix Gaschi , Jun Bin Cheng , En-Shiun Annie Lee

Data quality is an important consideration in many engineering applications and projects. Data collection procedures do not always involve careful utilization of the most precise instruments and strictest protocols. As a consequence, data…

Methodology · Statistics 2023-03-02 Krasymyr Tretiak , Scott Ferson

Statistical hypothesis testing serves as statistical evidence for scientific innovation. However, if the reported results are intentionally biased, hypothesis testing no longer controls the rate of false discovery. In particular, we study…

Methodology · Statistics 2018-10-12 Junpei Komiyama , Takanori Maehara

Data analysis based on information from several sources is common in economic and biomedical studies. This setting is often referred to as the data fusion problem, which differs from traditional missing data problems since no complete data…

Methodology · Statistics 2022-04-07 Wei Li , Shanshan Luo , Wangli Xu

Modern statisticians are often presented with hundreds or thousands of hypothesis testing problems to evaluate at the same time, generated from new scientific technologies such as microarrays, medical and satellite imaging devices, or flow…

Applications · Statistics 2008-12-18 Bradley Efron

When estimating causal effects using observational data, it is desirable to replicate a randomized experiment as closely as possible by obtaining treated and control groups with similar covariate distributions. This goal can often be…

Methodology · Statistics 2010-10-28 Elizabeth A. Stuart

In many application domains such as medicine, information retrieval, cybersecurity, social media, etc., datasets used for inducing classification models often have an unequal distribution of the instances of each class. This situation,…

Machine Learning · Computer Science 2022-01-21 Mohamed S. Kraiem , Fernando Sánchez-Hernández , María N. Moreno-García