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The liquid-liquid phase separation of biomolecules is an important process for intracellular organization. Biomolecular sequence combinatorics leads to a large variety of proteins and nucleic acids which can interact to form a diversity of…

Soft Condensed Matter · Physics 2025-08-27 Aria S. Chaderjian , Sam Wilken , Omar A. Saleh

The phase separation mechanism of a binary liquid mixture off-critically quenched in its miscibility gap is nucleation and growth, its homogeneous phase reaching a metastable equilibrium state. The successive stages of growth of the…

Statistical Mechanics · Physics 2009-11-18 Jean Colombani , Jacques Bert

Conventional phase segregation is controlled by a positive interfacial tension, which implies that the system relaxes towards a state in which the interfacial area (or length) is minimized, typically manifesting as a single droplet that…

Soft Condensed Matter · Physics 2025-09-24 Kathrin Hertäg , Joshua F. Robinson , Thomas Speck

Liquid-liquid phase separation is an important mechanism for compartmentalizing the cell's cytoplasm, allowing the dynamic organization of the components necessary for survival. However, it is not clear how phase separation is affected by…

Soft Condensed Matter · Physics 2022-01-31 Estefania Vidal-Henriquez , David Zwicker

We compare six elastic models for polymer networks in the context of phase separation within a gel, including a new model that combines the finite extensible Arruda-Boyce model and the slip tube model for entangled chains. We study…

Soft Condensed Matter · Physics 2025-10-08 Shichen Wang , Peter D. Olmsted

RNA molecules in living cells form what look like liquid droplets formed by liquid/liquid phase separation. But unlike the molecules in conventional phase separating mixtures, RNA molecules are transported by molecular motors that consume…

Soft Condensed Matter · Physics 2015-03-27 Richard P. Sear

We use a continuum model to examine the effect of activity on a phase separating mixture of an extensile active nematic and a passive fluid. We highlight the distinct role of previously considered interfacial active stresses and bulk active…

Soft Condensed Matter · Physics 2022-12-26 Fernando Caballero , M. Cristina Marchetti

Biological cells use droplets to separate components and spatially control their interior. Experiments demonstrate that the complex, crowded cellular environment affects the droplet arrangement and their sizes. To understand this behavior,…

Soft Condensed Matter · Physics 2021-10-27 Estefania Vidal-Henriquez , David Zwicker

The process of phase separation in elastic solids and viscous fluids is of fundamental importance to the stability and function of soft materials. We explore the dynamics of phase separation and domain growth in a viscoelastic material such…

Soft Condensed Matter · Physics 2023-03-24 Tine Curk , Erik Luijten

Liquid-liquid phase separation is important across biology, physics, and materials science. Although usually studied at equilibrium, active components - such as motor proteins, enzymes, and synthetic microswimmers - are increasingly…

Soft Condensed Matter · Physics 2026-01-06 Kan Chang , Yulin Li , Ming Yuan , Masaki Sano , Zhihong You , H. P. Zhang

Liquid-liquid phase separation is key to understanding aqueous two-phase systems (ATPS) arising throughout cell biology, medical science, and the pharmaceutical industry. Controlling the detailed morphology of phase-separating compound…

Soft Condensed Matter · Physics 2023-10-27 Eric W. Hester , Sean P. Carney , Vishwesh Shah , Alyssa Arnheim , Bena Patel , Dino Di Carlo , Andrea L. Bertozzi

Proteins and nucleic acids can spontaneously self-assemble into membraneless droplet-like compartments, both in vitro and in vivo. A key component of these droplets are multi-valent proteins that possess several adhesive domains with…

Biomolecules · Quantitative Biology 2020-01-10 Srivastav Ranganathan , Eugene Shakhnovich

We present a minimal model to study liquid phase separation in a fixed pH ensemble. The model describes a mixture composed of macromolecules that exist in three different charge states and have a tendency to phase separate. We introduce the…

Biological Physics · Physics 2020-10-30 Omar Adame-Arana , Christoph A. Weber , Vasily Zaburdaev , Jacques Prost , Frank Jülicher

Pattern formation inside a liquid phase is a phenomenon involved in many different aspects of life on our planet. The droplet form of a liquid that evaporates can reveal patterns that depend on the chemistry of the droplet and the physical…

Soft Condensed Matter · Physics 2024-09-12 Vahid Nasirimarekani

The precise control of liquid-liquid phase separation (LLPS) is the key to developing cutting-edge technologies that benefit diverse disciplines. Fluid flow was found to be capable of controlling the structure and effective temperature of…

Fluid Dynamics · Physics 2024-07-04 Yulin Li , Tong Zhou , Yanyu Li , Qi Zhang , Zhihong You

Whereas entropy can induce phase behavior that is as rich as seen in energetic systems, microphase separation remains a very rare phenomenon in entropic systems. In this paper, we present a density functional approach to study the…

Soft Condensed Matter · Physics 2009-11-10 Paul P. F. Wessels , Bela M. Mulder

Phase separation can drive spatial organization of multicomponent mixtures. For instance in developing animal embryos, effective phase separation descriptions have been used to account for the spatial organization of different tissue types.…

Soft Condensed Matter · Physics 2023-01-18 Simon Gsell , Matthias Merkel

Elastic interactions arising from a difference of lattice spacing between two coherent phases can have a strong influence on the phase separation (coarsening) of alloys. If the elastic moduli are different in the two phases, the elastic…

Mathematical Physics · Physics 2015-06-26 P. Fratzl , O. Penrose , J. L. Lebowitz

We study the structure and dynamics of a transient network composed of droplets of microemulsion connected by telechelic polymers. The polymer induces a bridging attraction between droplets without changing their shape. A viscoelastic…

Soft Condensed Matter · Physics 2009-10-31 F. Molino , J. Appell , M. Filali , E. Michel , G. Porte , S. Mora , E. Sunyer

The aerodynamic breakup of a polymeric droplet in the bag breakup regime is investigated experimentally and compared with the result of the Newtonian droplet. To understand the effect of liquid elasticity, the Weber number is kept fixed…

Fluid Dynamics · Physics 2023-09-27 Navin Kumar Chandra , Shubham Sharma , Saptarshi Basu , Aloke Kumar