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Transcription factors regulate gene expression, but how these proteins recognize and specifically bind to their DNA targets is still debated. Machine learning models are effective means to reveal interaction mechanisms. Here we studied the…

Quantum Physics · Physics 2018-03-02 Richard Y. Li , Rosa Di Felice , Remo Rohs , Daniel A. Lidar

Exploiting quantum properties to outperform classical ways of information-processing is an outstanding goal of modern physics. A promising route is quantum simulation, which aims at implementing relevant and computationally hard problems in…

In the field of quantum information, classical optimizers play an important role. From experimentalists optimizing their physical devices to theorists exploring variational quantum algorithms, many aspects of quantum information require the…

Quantum Physics · Physics 2023-10-17 Lucas Tecot , Cho-Jui Hsieh

This work proposes a hybrid framework combining classical computers with quantum annealers for structural optimisation. At each optimisation iteration of an iterative process, two minimisation problems are formulated one for the underlying…

Computational Engineering, Finance, and Science · Computer Science 2025-10-27 Van-Dung Nguyen , Erin Kuci , Michel Rasquin , Ludovic Noels

Quantum Variational Circuits (QVCs) are often claimed as one of the most potent uses of both near term and long term quantum hardware. The standard approaches to optimizing these circuits rely on a classical system to compute the new…

Quantum Physics · Physics 2022-02-11 Owen Lockwood

Recent advances in quantum technology have led to the development and manufacturing of experimental programmable quantum annealers that promise to solve certain combinatorial optimization problems of practical relevance faster than their…

Quantum Physics · Physics 2016-05-31 Itay Hen , Federico M. Spedalieri

Quantum annealing is a promising paradigm for building practical quantum computers. Compared to other approaches, quantum annealing technology has been scaled up to a larger number of qubits. On the other hand, deep learning has been…

Quantum Physics · Physics 2021-07-07 Michele Sasdelli , Tat-Jun Chin

In recent years, quantum, quantum-inspired, and hybrid algorithms are increasingly showing promise for solving software engineering optimization problems. However, best-intended practices for conducting empirical studies have not yet well…

Software Engineering · Computer Science 2025-11-03 Man Zhang , Yuechen Li , Tao Yue , Kai-Yuan Cai

We investigate the use of quantum computing algorithms on real quantum hardware to tackle the computationally intensive task of feature selection for light-weight medical image datasets. Feature selection is often formulated as a k of n…

Quantum Physics · Physics 2025-02-27 Merlin A. Nau , Luca A. Nutricati , Bruno Camino , Paul A. Warburton , Andreas K. Maier

In this work, we review quantum approaches to combinatorial optimization, with the aim of bridging theoretical developments and industrial relevance. We first survey the main families of quantum algorithms, including Quantum Annealing, the…

Quantum Physics · Physics 2026-03-20 Hala Hawashin , Deep Nath , Marco Alberto Javarone

Quantum annealing provides a promising route for the development of quantum optimization devices, but the usefulness of such devices will be limited in part by the range of implementable problems as dictated by hardware constraints. To…

Quantum Physics · Physics 2015-10-14 Walter Vinci , Tameem Albash , Gerardo Paz-Silva , Itay Hen , Daniel A. Lidar

Quantum(-inspired) annealers show promise in solving combinatorial optimisation problems in practice. There has been extensive researches demonstrating the utility of D-Wave quantum annealer and quantum-inspired annealer, i.e., Fujitsu…

Quantum Physics · Physics 2022-09-27 Tian Huang , Jun Xu , Tao Luo , Xiaozhe Gu , Rick Goh , Weng-Fai Wong

We investigate an efficient, generic method for evaluating the performance of quantum annealing devices that does not require the prior knowledge of the true ground state of the benchmark problem. This approach exploits symmetry properties…

Quantum Physics · Physics 2022-01-06 Dilina Perera , Bhavika Bhalgamiya , M. A. Novotny

This paper explores the applications of quantum annealing (QA) and classical simulated annealing (SA) to a suite of combinatorial optimization problems in machine learning, namely feature selection, instance selection, and clustering. We…

Quantum Physics · Physics 2025-07-22 Chloe Pomeroy , Aleksandar Pramov , Karishma Thakrar , Lakshmi Yendapalli

Markov chain Monte Carlo algorithms have important applications in counting problems and in machine learning problems, settings that involve estimating quantities that are difficult to compute exactly. How much can quantum computers speed…

Quantum Physics · Physics 2020-02-10 Aram W. Harrow , Annie Y. Wei

In the quantum optimization paradigm, variational quantum algorithms face challenges with hardware-specific and instance-dependent parameter tuning, which can lead to computational inefficiencies. The promising potential of parameter…

Real-world optimization problems must undergo a series of transformations before becoming solvable on current quantum hardware. Even for a fixed problem, the number of possible transformation paths -- from industry-relevant formulations…

Quantum computation is a promising emerging technology, and by utilizing the principles of quantum mechanics, it is expected to achieve faster computations than classical computers for specific problems. There are two distinct architectures…

Quantum Physics · Physics 2025-03-13 Takashi Imoto , Yuki Susa , Ryoji Miyazaki , Yuichiro Matsuzaki

There have been multiple attempts to design synthetic benchmark problems with the goal of detecting quantum speedup in current quantum annealing machines. To date, classical heuristics have consistently outperformed quantum-annealing based…

Quantum Physics · Physics 2018-07-04 Salvatore Mandrà , Helmut G. Katzgraber
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