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This research gives a thorough examination of an HIV infection model that includes quiescent cells and immune response dynamics in the host. The model, represented by a system of ordinary differential equations, captures the complex…

Populations and Evolution · Quantitative Biology 2025-03-04 Ibrahim Nali , Attila Dénes , Abdessamad Tridane , Xueyong Zhou

Objective: The reservoir of human immunodeficiency virus (HIV) latently infected cells is the major obstacle for eradication of acquired immunodeficiency syndrome (AIDS). Due to the noisy environment and multiple influencing factors in the…

Biological Physics · Physics 2024-11-06 Ruiqi Xiong , Yang Su , Ping Ao

Mathematical modeling of biological systems is crucial to effectively and efficiently developing treatments for medical conditions that plague humanity. Often, systems of ordinary differential equations are a traditional tool used to…

Classical Analysis and ODEs · Mathematics 2015-09-01 Eric Jones , Peter Roemer , Mrinal Raghupathi , Stephen Pankavich

The control of opportunistic infections among HIV infected individuals should be one of the major public health concerns in reducing mortality rate of individuals living with HIV/AIDS. In this study a deterministic co-infection mathematical…

Dynamical Systems · Mathematics 2024-08-02 Michael Byamukama , Damian Kajunguri , Martin Karuhanga

In this paper, we develop a dynamic model of HIV infection that incorporates latent hosts, cytotoxic T lymphocyte (CTL) immunity, saturated incidence rates, and two transmission mechanisms: virus-to-cell and cell-to-cell transmission. The…

Dynamical Systems · Mathematics 2025-11-25 Songbo Hou , Xinxin Tian

In this paper, we investigate a novel 3-compartment model of HIV infection of CD4$^+$ T-cells with a mass action term by including two versions: one baseline ODE model and one delay-differential equation (DDE) model with a constant discrete…

Populations and Evolution · Quantitative Biology 2021-01-05 Hoang Anh Ngo , Hung Dang Nguyen , Mehmet Dik

We consider a time-delayed HIV/AIDS epidemic model with education dissemination and study the asymptotic dynamics of solutions as well as the asymptotic behavior of the endemic equilibrium with respect to the amount of information…

Dynamical Systems · Mathematics 2021-08-10 Dawit Denu , Sedar Ngoma , Rachidi B. Salako

In this paper, we propose a mathematical model for HIV-1 infection with intracellular delay. The model examines a viral-therapy for controlling infections through recombining HIV-1 virus with a genetically modified virus. For this model,…

Dynamical Systems · Mathematics 2014-04-10 Yun Tian , Yu Bai , Pei Yu

We consider a Human Immunodeficiency Virus (HIV) model with a logistic growth term and continue the analysis of the previous article [6]. We now take the viral diffusion in a two-dimensional environment. The model consists of two ODEs for…

Analysis of PDEs · Mathematics 2012-11-02 Claude-Michel Brauner , Xinyue Fan , Luca Lorenzi

In this work we introduce a differential equation model with time-delay that describes the three-stage dynamics and the two time scales observed in HIV infection. Assuming that the virus has high mutation and rapid reproduction rates that…

Biological Physics · Physics 2015-03-13 Flora S. Bacelar , Roberto F. S. Andrade , Rita M. Zorzenon dos Santos

In this article, we consider an HIV/AIDS epidemic model with four classes of individuals. We have discussed about basic properties of the system and found the basic reproduction number $R_0$ of the system. The stability analysis of the…

Dynamical Systems · Mathematics 2023-04-18 Nouar Chorfi , Salem Abdelmalek , Samir Bendoukha

Recently, a long-term model of HIV infection dynamics was developed to describe the entire time course of the disease. It consists of a large system of ODEs with many parameters, and is expensive to simulate. In the current paper, this…

Populations and Evolution · Quantitative Biology 2016-04-20 Tyson Loudon , Stephen Pankavich

In [Math. Comput. Sci. 12 (2018), no. 2, 111--127], a delayed model describing the dynamics of the Human Immunodeficiency Virus (HIV) with Cytotoxic T Lymphocytes (CTL) immune response is investigated by Allali, Harroudi and Torres. Here,…

Dynamical Systems · Mathematics 2022-10-03 Sandra Vaz , Delfim F. M. Torres

A central challenge in Human Immunodeficiency Virus (HIV) public health policy lies in determining whether to universally expand treatment access, despite the risk of sub-optimal adherence and consequent drug resistance, or to adopt a more…

Quantitative Methods · Quantitative Biology 2025-07-16 Ashish Poonia , Siddhartha P. Chakrabarty

The purpose of this paper is to analyze the mechanism for the interplay of deterministic and stochastic models for contagious diseases. Deterministic models for contagious diseases are prone to predict global stability. Small natural birth…

Populations and Evolution · Quantitative Biology 2022-06-17 Torsten Lindström

We study within-host HIV dynamics using a three--component nonlinear ordinary differential equation model for healthy CD4$^{+}$ T cells, infected CD4$^{+}$ T cells, and free virus. In addition to the baseline model without treatment, we…

Numerical Analysis · Mathematics 2025-12-16 Abdul Rab

A dynamic model of non-lineal time-dependent ordinary differential equations (ODE) has been applied to the interactions of a HIV infection with the immune system cells. This model has been simplified into two compartments: lymph node and…

Cell Behavior · Quantitative Biology 2020-08-07 Miguel Ramos Pascual

Physiological stress fundamentally alters disease susceptibility in aquatic environments. In this paper, we develop a stress-structured epidemiological model where host vulnerability is dynamically driven by water quality. Analytically, we…

Populations and Evolution · Quantitative Biology 2026-02-10 Clotilde Djuikem , Julien Arino

A ternary reaction-diffusion model for early HIV infection dynamics, incorporating logistic growth of target cells, is introduced. According to in vitro and in vivo studies, random movement of target cells, infected cells, and virions and a…

Populations and Evolution · Quantitative Biology 2024-10-21 Florinda Capone , Roberta De Luca , Vincenzo Luongo

We propose and investigate a delayed model that studies the relationship between HIV and the immune system during the natural course of infection and in the context of antiviral treatment regimes. Sufficient criteria for local asymptotic…

Optimization and Control · Mathematics 2018-03-19 Diana Rocha , Cristiana J. Silva , Delfim F. M. Torres
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