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Background: Significance analysis plays a major role in identifying and ranking genes, transcription factor binding sites, DNA methylation regions, and other high-throughput features for association with disease. We propose a new approach,…

Methodology · Statistics 2017-01-10 Andrew E. Jaffe , John D. Storey , Hongkai Ji , Jeffrey T. Leek

Ongoing progress in computational intelligence (CI) has led to an increased desire to apply CI techniques for the purpose of improving software engineering processes, particularly software testing. Existing state-of-the-art automated…

Neural and Evolutionary Computing · Computer Science 2023-02-16 Jarrod Goschen , Anna Sergeevna Bosman , Stefan Gruner

The existence of generalized steady states (GSSs) in nonlinear mechanical systems under moderate temporally aperiodic forcing has only been shown recently. Here we derive systematic expansions for such GSSs and construct a numerical…

Dynamical Systems · Mathematics 2026-02-20 Roshan S. Kaundinya , Isabella Thiel , Bálint Kaszás , Shobhit Jain , George Haller

A valuable step in the modeling of multiscale dynamical systems in fields such as computational chemistry, biology, materials science and more, is the representative sampling of the phase space over long timescales of interest; this task is…

Machine Learning · Computer Science 2023-12-29 Ellis R. Crabtree , Juan M. Bello-Rivas , Ioannis G. Kevrekidis

Symbolic regression is the process of identifying mathematical expressions that fit observed output from a black-box process. It is a discrete optimization problem generally believed to be NP-hard. Prior approaches to solving the problem…

Neural and Evolutionary Computing · Computer Science 2021-11-19 T. Nathan Mundhenk , Mikel Landajuela , Ruben Glatt , Claudio P. Santiago , Daniel M. Faissol , Brenden K. Petersen

Automated vehicles require efficient and safe planning to maneuver in uncertain environments. Largely this uncertainty is caused by other traffic participants, e.g., surrounding vehicles. Future motion of surrounding vehicles is often…

Systems and Control · Electrical Eng. & Systems 2022-06-09 Tim Brüdigam , Michael Olbrich , Dirk Wollherr , Marion Leibold

Prompt-based techniques have demostrated great potential for improving the few-shot generalization of pretrained language models. However, their performance heavily relies on the manual design of prompts and thus requires a lot of human…

Computation and Language · Computer Science 2022-11-01 Hanwei Xu , Yujun Chen , Yulun Du , Nan Shao , Yanggang Wang , Haiyu Li , Zhilin Yang

Symbolic regression is a powerful system identification technique in industrial scenarios where no prior knowledge on model structure is available. Such scenarios often require specific model properties such as interpretability, robustness,…

This paper concerns applications of genetic algorithms and genetic programming to tasks for which it is difficult to find a representation that does not map to a highly complex and discontinuous fitness landscape. In such cases the standard…

Neural and Evolutionary Computing · Computer Science 2016-05-06 Michal Gregor , Juraj Spalek

Genetic variation in human populations is influenced by geographic ancestry due to spatial locality in historical mating and migration patterns. Spatial population structure in genetic datasets has been traditionally analyzed using either…

Populations and Evolution · Quantitative Biology 2016-10-26 Anand Bhaskar , Adel Javanmard , Thomas A. Courtade , David Tse

Motivation: Most existing methods for DNA sequence analysis rely on accurate sequences or genotypes. However, in applications of the next-generation sequencing (NGS), accurate genotypes may not be easily obtained (e.g. multi-sample…

Genomics · Quantitative Biology 2013-03-19 Heng Li

Self-supervised pre-training based on next-token prediction has enabled large language models to capture the underlying structure of text, and has led to unprecedented performance on a large array of tasks when applied at scale. Similarly,…

A class of algorithms for the Landau gauge fixing is proposed, which makes the steepest ascent (SA) method be more efficient by concepts of genetic algorithm. Main concern is how to incorporate random gauge transformation (RGT) %, mutation…

High Energy Physics - Lattice · Physics 2015-06-25 Azusa Yamaguchi , Hideo Nakajima

In this paper we describe SYNERGY, which is a highly parallelizable, linear planning system that is based on the genetic programming paradigm. Rather than reasoning about the world it is planning for, SYNERGY uses artificial selection,…

Artificial Intelligence · Computer Science 2007-05-23 Ion Muslea

This paper investigates a novel problem, namely the Uncertain Agile Earth Observation Satellite Scheduling Problem (UAEOSSP). Unlike the static AEOSSP, it takes into account a range of uncertain factors (e.g., task profit, resource…

Neural and Evolutionary Computing · Computer Science 2026-02-18 Yuning Chen , Junhua Xue , Wangqi Gu , Mingyan Shao

Reinforcement learning is essential for neural architecture search and hyperparameter optimization, but the conventional approaches impede widespread use due to prohibitive time and computational costs. Inspired by DeepSeek-V3 multi-token…

Machine Learning · Computer Science 2025-06-19 Zheng Li , Jerry Cheng , Huanying Helen Gu

Individual's semantics have been used for guiding the learning process of Genetic Programming solving supervised learning problems. The semantics has been used to proposed novel genetic operators as well as different ways of performing…

Machine Learning · Computer Science 2021-04-06 Claudia N. Sánchez , Mario Graff

Software development projects management is a complex endeavor because it requires dealing with numerous unforeseen events that constantly arise along the way and that go against the expectations that had been established at the beginning.…

Software Engineering · Computer Science 2022-09-27 Fernando Pinciroli

Stochastic gradient descent with momentum (SGDM) is one of the most widely used optimization algorithms in machine learning. While optimization properties of SGDM have been extensively studied in the literature, it remains insufficiently…

Machine Learning · Computer Science 2026-05-28 Yunwen Lei , Zimeng Wang , Xiaoming Yuan

Stochastic gradient descent in continuous time (SGDCT) provides a computationally efficient method for the statistical learning of continuous-time models, which are widely used in science, engineering, and finance. The SGDCT algorithm…

Probability · Mathematics 2017-10-31 Justin Sirignano , Konstantinos Spiliopoulos