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I consider the microscopic mechanisms by which a particular left-right (L/R) asymmetry is generated at the organism level from the microscopic handedness of cytoskeletal molecules. In light of a fundamental symmetry principle, the typical…

Subcellular Processes · Quantitative Biology 2015-06-03 Christopher L. Henley

Understanding chirality transfer from the molecular to the macroscopic scale poses a significant challenge in soft and biological condensed matter physics. Many nanorods of biological origin not only have chiral molecular features but also…

Soft Condensed Matter · Physics 2026-01-30 William S. Fall , Henricus H. Wensink

In multicellular organisms, epithelial cells form layers separating compartments responsible for different physiological functions. At the early stage of epithelial layer formation, each cell of an aggregate defines an inner and an outer…

Cell Behavior · Quantitative Biology 2010-02-09 A. Veglio , A. Gamba , M. Nicodemi , F. Bussolino , G. Serini

In condensed matter physics, a broad spectrum of physical characteristics, such as chirality, axiality, and polarity, arises as a direct consequence of the underlying symmetry of the system. We here theoretically investigate the effective…

Strongly Correlated Electrons · Physics 2025-11-12 Satoru Hayami , Rikuto Oiwa , Akane Inda

Chirality is an important concept that describes the asymmetry property of a system, which usually emerges spontaneously due to mirror symmetry breaking. Such spontaneous chirality manifests predominantly as parity breaking in modern…

Polar active particles constitute a wide class of synthetic colloids that are able to propel along a preferential direction, given by their polar axis. Here, we demonstrate a generic self-phoretic mechanism that leads to their spontaneous…

Soft Condensed Matter · Physics 2021-10-27 Marco De Corato , Ignacio Pagonabarraga , Giovanniantonio Natale

Chirality is a pervasive form of symmetry that is intimately connected to the physical properties of solids, as well as the chemical and biological activity of molecular systems. However, its control with light is challenging, because…

Materials Science · Physics 2025-06-13 Z. Zeng , M. Först , M. Fechner , M. Buzzi , E. Amuah , C. Putzke , P. J. W. Moll , D. Prabhakaran , P. Radaelli , A. Cavalleri

Chiral symmetry breaking occurs when a physical or chemical process, with no preference for the production of one or other enantiomer, spontaneously generates a large excess of one of the two enantiomers: (L), left-handed or (D), right…

Other Condensed Matter · Physics 2007-05-23 Cristobal Viedma

Chirality is a ubiquitous phenomenon in which a symmetry between left- and right-handed objects is broken, examples in nature ranging from subatomic particles and molecules to living organisms. In particle physics, the weak force is…

Chiral symmetry breaking is ubiquitous in biological systems, from DNA to bacterial suspensions. A key unresolved problem is how chiral structures may spontaneously emerge from achiral interactions. We study a simple model of bacterial…

Soft Condensed Matter · Physics 2016-08-18 Rebekka E. Breier , Robin L. B. Selinger , Giovanni Ciccotti , Stephan Herminghaus , Marco G. Mazza

Many of the biological phenomena involve collective dynamics driven by self-propelled motion and nonequilibrium force (i.e., activity) that result in features unexpected from equilibrium physics. On the other hand, biological experiments…

Soft Condensed Matter · Physics 2020-09-08 Lisa Yamauchi , Tomoya Hayata , Masahito Uwamichi , Tomoki Ozawa , Kyogo Kawaguchi

We show that chiral symmetry can be broken spontaneously in one-component systems with isotropic interactions, i.e. many-particle systems having maximal a priori symmetry. This is achieved by designing isotropic potentials that lead to…

Materials Science · Physics 2012-05-16 Erik Edlund , Oskar Lindgren , Martin Nilsson Jacobi

Chirality is a feature of many biological systems and much research has been focused on understanding the origin and implications of this property. Famously, sugars and amino acids found in nature are homochiral, i.e., chiral symmetry is…

Cell Behavior · Quantitative Biology 2023-07-28 Ludwig A. Hoffmann , Luca Giomi

The occurrence of biological homochirality is attributed to symmetry breaking mechanisms which are still debatable1. Studies of symmetry breaking require tools for monitoring the population ratios of individual chiral nano-objects, such as…

Optics · Physics 2018-08-20 Eitam Vinegrad , Uri Hananel , Gil Markovich , Ori Cheshnovsky

It has been long recognized that the spatial polarization of the electronic clouds in molecules, and the spatial arrangements of atoms into chiral molecular structures, play crucial roles in physics, chemistry and biology. However, these…

Optics · Physics 2020-04-14 David Ayuso , Andres Ordonez , Piero Decleva , Misha Ivanov , Olga Smirnova

To understand the relationship between the chirality of individual cells and that of tissues and organisms, we have developed a chiral polarized particle model to investigate the movement of cell populations on substrates. Our model…

Biological Physics · Physics 2024-07-02 Xi Li , Bin Chen

Living systems have evolved to efficiently consume available energy sources using an elaborate circuitry of chemical reactions which, puzzlingly, bear a strict restriction to asymmetric chiral configurations. While autocatalysis is known to…

Chemical Physics · Physics 2022-05-25 William D. Piñeros , Tsvi Tlusty

Chirality plays a crucial role in determining the structure of many systems in nature. Twisted or helical aggregates as a consequence of self-assembly can be seen in many biological and synthetic materials. Despite extensive theoretical and…

Soft Condensed Matter · Physics 2026-05-27 Sayantan Mondal , Jayashree Saha

We study quantum systems with broken symmetry that can be modelled as cyclic three-level atoms with coexisting one- and two-photon transitions. They can be selectively optically excited to any state. As an example, we show that left- and…

Quantum Physics · Physics 2008-01-28 Yong Li , C. Bruder

The origin of recently observed spontaneous chiral symmetry breaking in polar fluids is an unsolved problem, and poses fundamental questions as to how heliconical structures emerge in systems composed of achiral molecules. We report on the…

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