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In mathematical epidemiology, epidemic control often aims at driving the number of infected individuals to zero, asymptotically. However , during the transitory phase, the number of infected can peak at high values. In this paper, we…
It is possible to model vector-borne infection using the classical Ross-Macdonald model. This attempt, however fails in several respects. First, using measured (or estimated) parameters, the model predicts a much greater number of cases…
We consider sustainable management issues formulated within the framework of control theory. The problem is one of controlling a discrete--time dynamical system (e.g. population model) in the presence of state and control constraints,…
The relationship between epidemiology, mathematical modeling and computational tools allows to build and test theories on the development and battling of a disease. This PhD thesis is motivated by the study of epidemiological models applied…
Dengue is one of the most important infectious diseases in the world, in terms of death and economic cost. Hence, the modeling of dengue is of great importance to help us understand the dynamics disease, and interfering with its spreading…
We investigate how key epidemiological parameters shape both seasonal epidemics and the persistence of dengue transmission. Our findings confirm known mechanistic drivers of epidemic variability and introduce a ranking of parameter…
We present an application of optimal control theory to Dengue epidemics. This epidemiologic disease is an important theme in tropical countries due to the growing number of infected individuals. The dynamic model is described by a set of…
Dengue is a vector-borne disease transmitted by Aedes mosquitoes. The worldwide spread of these mosquitoes and the increasing disease burden have emphasized the need for a spatio-temporal risk map capable of assessing dengue outbreak…
The model considers the human population, the adult mosquito population and the population of immature stages, which includes eggs, larvae and pupae. The model also considers the vertical transmission of dengue in the mosquitoes and the…
Dengue transmission is shaped by the population dynamics of the Aedes aegypti mosquito, making vector control a central strategy for disease mitigation. The impact of interventions such as larvicide, adulticide, and breeding-site reduction…
Mosquitoes are vectors of viral diseases with epidemic potential in many regions of the world, and in absence of vaccines or therapies, their control is the main alternative. Chemical control through insecticides has been one of the…
Dengue is one of the major international public health concerns. Although progress is underway, developing a vaccine against the disease is challenging. Thus, the main approach to fight the disease is vector control. A model for the…
Dengue is a vector-borne disease transmitted from an infected human to an Aedes mosquito, during a blood-meal. Dengue is still a major public health problem. A model for the disease transmission is presented, composed by human and…
A model for the transmission of dengue disease is presented. It consists of eight mutually-exclusive compartments representing the human and vector dynamics. It also includes a control parameter (adulticide spray) in order to combat the…
A model for the transmission of dengue disease is presented. It consists of eight mutually-exclusive compartments representing the human and vector dynamics. It also includes a control parameter (insecticide) in order to fight the…
Aedes aegypti is known as the responsible vector transmitting dengue flavivirus. Unavailability of medication to cure the transmission of the virus in the human blood becomes a global health issue in recent decades. World epidemiologists…
A model with six mutually-exclusive compartments related to dengue is studied. Three vector control tools are considered: insecticides (larvicide and adulticide) and mechanical control. The basic reproduction number associated to the model…
In stochastic control applications, typically only an ideal model (controlled transition kernel) is assumed and the control design is based on the given model, raising the problem of performance loss due to the mismatch between the assumed…
A model with six mutually-exclusive compartments related to Dengue disease is presented. In this model there are three vector control tools: insecticides (larvicide and adulticide) and mechanical control. The problem is studied using an…
Controlling diseases such as dengue fever, chikungunya and zika fever by introduction of the intracellular parasitic bacterium Wolbachia in mosquito populations which are their vectors, is presently quite a promising tool to reduce their…