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In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

Numerical Analysis · Mathematics 2022-05-09 Harald Garcke , Dennis Trautwein

We perform a rigorous examination of the sharp interface limit of a coupled Navier-Stokes and mass-conserving Allen-Cahn system in a two-dimensional, bounded, and smooth domain as the parameter $\varepsilon > 0$, representing the thickness…

Analysis of PDEs · Mathematics 2026-04-14 Helmut Abels , Hanifah Mumtaz

This paper studies asymptotic behavior of solutions of a free boundary problem modeling the growth of tumors with two species of cells: proliferating cells and quiecent cells. In previous literatures it has been proved that this problem has…

Analysis of PDEs · Mathematics 2013-03-18 Shangbin Cui

We consider a diffuse interface model for tumor growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation, which models a tumor growing in the presence of a nutrient species and surrounded by…

Analysis of PDEs · Mathematics 2017-05-04 Harald Garcke , Kei Fong Lam

We investigate the convergence of solutions of a recently proposed diffuse interface/phase field model for cell blebbing by means of matched asymptotic expansions. It is a biological phenomenon that increasingly attracts attention by both…

Analysis of PDEs · Mathematics 2023-02-10 Philipp Nöldner , Martin Burger , Harald Garcke

This paper provides a unified mathematical analysis of a family of non-local diffuse interface models for tumor growth describing evolutions driven by long-range interactions. These integro-partial differential equations model cell-to-cell…

Analysis of PDEs · Mathematics 2021-07-07 Luca Scarpa , Andrea Signori

A new diffuse interface model for a two-phase flow of two incompressible fluids with different densities is introduced using methods from rational continuum mechanics. The model fulfills local and global dissipation inequalities and is also…

Fluid Dynamics · Physics 2010-11-03 Helmut Abels , Harald Garcke , Günther Grün

We investigate the long-time dynamics and optimal control problem of a diffuse interface model that describes the growth of a tumor in presence of a nutrient and surrounded by host tissues. The state system consists of a Cahn-Hilliard type…

Analysis of PDEs · Mathematics 2023-07-28 Cecilia Cavaterra , Elisabetta Rocca , Hao Wu

In this paper, we study a distributed optimal control problem for a diffuse interface model for tumor growth. The model consists of a Cahn-Hilliard type equation for the phase field variable coupled to a reaction diffusion equation for the…

Optimization and Control · Mathematics 2021-10-12 Matthias Ebenbeck , Patrik Knopf

We investigate the general Porous Medium Equations with drift and source terms that model tumor growth. Incompressible limit of such models has been well-studied in the literature, where convergence of the density and pressure variables are…

Analysis of PDEs · Mathematics 2024-03-12 Jiajun Tong , Yuming Paul Zhang

A steady-state convection-diffusion problem with a small diffusion of order $\mathcal{O}(\varepsilon)$ is considered in a thin three-dimensional graph-like junction consisting of thin cylinders connected through a domain (node) of diameter…

Analysis of PDEs · Mathematics 2022-08-12 Taras A. Mel'nyk , Arsen V. Klevtsovskiy

This paper studies the sharp interface limit for a mass conserving Allen-Cahn equation added an external noise and derives a stochastically perturbed mass conserving mean curvature flow in the limit. The stochastic term destroys the precise…

Probability · Mathematics 2016-12-30 Tadahisa Funaki , Satoshi Yokoyama

Interfaces in a model with a single, real nonconserved order parameter and purely dissipative evolution equation are considered. We show that a systematic perturbative approach, called the expansion in width and developed for curved domain…

Soft Condensed Matter · Physics 2009-10-31 H. Arodz , R. Pelka

We consider an optimal control problem for a diffuse interface model of tumor growth. The state equations couples a Cahn-Hilliard equation and a reaction-diffusion equation, which models the growth of a tumor in the presence of a nutrient…

Optimization and Control · Mathematics 2016-08-02 Harald Garcke , Kei-Fong Lam , Elisabetta Rocca

We use a diffuse interface method for solving Poisson's equation with a Dirichlet condition on an embedded curved interface. The resulting diffuse interface problem is identified as a standard Dirichlet problem on approximating regular…

Numerical Analysis · Mathematics 2015-11-23 Matthias Schlottbom

We construct gradient structures for free boundary problems with nonlinear elasticity and study the impact of moving contact lines. In this context, we numerically analyze how phase-field models converge to certain sharp-interface limits…

Analysis of PDEs · Mathematics 2024-06-26 Leonie Schmeller , Dirk Peschka

We study the asymptotic limit of diffused surface energy in the van der Waals--Cahn--Hillard theory when an advection term is added and the energy is uniformly bounded. We prove that the limit interface is an integral varifold and the…

Analysis of PDEs · Mathematics 2020-10-12 Yoshihiro Tonegawa , Yuki Tsukamoto

Cancer is a very complex phenomenon that involves many different scales and situations. In this paper we consider a free boundary problem describing the evolution of a tumor colony and we derive a new asymptotic model for tumor growth. We…

Analysis of PDEs · Mathematics 2025-04-15 Rafael Granero-Belinchón , Martina Magliocca

We investigate the sharp material interface limit of the Darcy-Boussinesq model for convection in layered porous media with diffused material interfaces, which allow a gradual transition of material parameters between different layers. We…

Analysis of PDEs · Mathematics 2025-04-25 Hongjie Dong , Xiaoming Wang

We consider the sharp interface limit of a coupled Stokes/Cahn\textendash Hilliard system in a two dimensional, bounded and smooth domain, i.e., we consider the limiting behavior of solutions when a parameter $\epsilon>0$ corresponding to…

Analysis of PDEs · Mathematics 2020-04-02 Helmut Abels , Andreas Marquardt