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Familywise error rate (FWER) has been a cornerstone in simultaneous inference for decades, and the classical Bonferroni method has been one of the most prominent frequentist approaches for controlling FWER. The present article studies the…

Statistics Theory · Mathematics 2021-12-07 Monitirtha Dey , Subir Kumar Bhandari

The field of brainwave-based biometrics has gained attention for its potential to revolutionize user authentication through hands-free interaction, resistance to shoulder surfing, continuous authentication, and revocability. However,…

Signal Processing · Electrical Eng. & Systems 2026-02-12 Matin Fallahi , Patricia Arias-Cabarcos , Thorsten Strufe

Over the last twenty five years, advances in the collection and analysis of fMRI data have enabled new insights into the brain basis of human health and disease. Individual behavioral variation can now be visualized at a neural level as…

Image and Video Processing · Electrical Eng. & Systems 2019-12-24 Matthew Kollada , Qingzhu Gao , Monika S Mellem , Tathagata Banerjee , William J Martin

A common feature in many neuroscience datasets is the presence of hierarchical data structures, most commonly recording the activity of multiple neurons in multiple animals across multiple trials. Accordingly, the measurements constituting…

Neurons and Cognition · Quantitative Biology 2020-07-17 Varun Saravanan , Gordon J Berman , Samuel J Sober

The process comparing the empirical cumulative distribution function of the sample with a parametric estimate of the cumulative distribution function is known as the empirical process with estimated parameters and has been extensively…

Methodology · Statistics 2012-10-08 Ivan Kojadinovic , Jun Yan

Structural and functional neuroimaging modalities provide complementary windows into brain organization: structural imaging characterizes neural tissue anatomy and microstructure, while functional imaging captures dynamic patterns of neural…

Methodology · Statistics 2026-03-24 Sakul Mahat , Sharmistha Guha , Jessica Bernard

In many large scale multiple testing applications, the hypotheses often have a known graphical structure, such as gene ontology in gene expression data. Exploiting this graphical structure in multiple testing procedures can improve power as…

Methodology · Statistics 2018-12-04 Wenge Guo , Gavin Lynch , Joseph P. Romano

Stepwise multiple testing procedures have attracted several statisticians for decades and are also quite popular with statistics users because of their technical simplicity. The Bonferroni procedure has been one of the earliest and most…

Statistics Theory · Mathematics 2023-02-21 Monitirtha Dey

We present a novel method for controlling the $k$-familywise error rate ($k$-FWER) in the linear regression setting using the knockoffs framework first introduced by Barber and Cand\`es. Our procedure, which we also refer to as knockoffs,…

Methodology · Statistics 2015-11-10 Lucas Janson , Weijie Su

The Gaussian Kinematic Formula (GKF) is a powerful and computationally efficient tool to perform statistical inference on random fields and became a well-established tool in the analysis of neuroimaging data. Using realistic error models,…

Methodology · Statistics 2024-04-17 Fabian JE Telschow , Samuel Davenport

In this paper,our main focus is to obtain an asymptotic bound on the family wise error rate (FWER) for Bonferroni-type procedure in the simultaneous hypotheses testing problem when the observations corresponding to individual hypothesis are…

Statistics Theory · Mathematics 2025-08-27 Nabaneet Das , Subir K. Bhandari

Group sequential design (GSD) is widely used in clinical trials in which correlated tests of multiple hypotheses are used. Multiple primary objectives resulting in tests with known correlations include evaluating 1) multiple experimental…

Methodology · Statistics 2021-03-22 Keaven M. Anderson , Zifang Guo , Jing Zhao , Linda Z. Sun

In genome-wide association (GWA) studies the goal is to detect association between one or more genetic markers and a given phenotype. The number of genetic markers in a GWA study can be in the order hundreds of thousands and therefore…

Methodology · Statistics 2016-12-22 Kari Krizak Halle , Srdjan Djurovic , Ole Andreas Andreassen , Mette Langaas

Meta-analyses require an effect-size estimate and its corresponding sampling variance from primary studies. In some cases, estimators for the sampling variance of a given effect size statistic may not exist, necessitating the derivation of…

The desire to train complex machine learning algorithms and to increase the statistical power in association studies drives neuroimaging research to use ever-larger datasets. The most obvious way to increase sample size is by pooling scans…

Computer Vision and Pattern Recognition · Computer Science 2020-10-29 Christian Wachinger , Anna Rieckmann , Sebastian Pölsterl

Traditional voxel-level multiple testing procedures in neuroimaging, mostly $p$-value based, often ignore the spatial correlations among neighboring voxels and thus suffer from substantial loss of power. We extend the…

Applications · Statistics 2016-07-29 Hai Shu , Bin Nan , Robert Koeppe

This paper investigates the accuracy of bootstrap-based bias correction of persistence measures for long memory fractionally integrated processes. The bootstrap method is based on the semi-parametric sieve approach, with the dynamics in the…

Methodology · Statistics 2016-03-08 Simone D. Grose , Gael M. Martin , Donald S. Poskitt

Normative modelling is an increasingly common statistical technique in neuroimaging that estimates population-level benchmarks in brain structure. It enables the quantification of individual deviations from expected distributions whilst…

Neurons and Cognition · Quantitative Biology 2025-10-21 Nida Alyas , Jonathan Horsley , Bethany Little , Peter N. Taylor , Yujiang Wang , Karoline Leiberg

X-ray imaging is a fundamental tool of routine clinical diagnosis. Fluoroscopic imaging can further acquire X-ray images at video frame rates, thus enabling non-invasive in-vivo motion studies of joints, gastrointestinal tract, etc. For…

Image and Video Processing · Electrical Eng. & Systems 2018-10-22 Jacky C. K. Chow , Derek Lichti , Kathleen Ang , Gregor Kuntze , Gulshan Sharma , Janet Ronsky

False discovery rate (FDR) control methods are essential for voxel-wise multiple testing in neuroimaging data analysis, where hundreds of thousands or even millions of tests are conducted to detect brain regions associated with…

Machine Learning · Statistics 2025-05-30 Taehyo Kim , Qiran Jia , Mony J. de Leon , Hai Shu