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We study theoretically the shapes of biological tubes affected by various pathologies. When epithelial cells grow at an uncontrolled rate, the negative tension produced by their division provokes a buckling instability. Several shapes are…

Biological Physics · Physics 2012-07-09 Edouard Hannezo , Jean-Francois Joanny , Jacques Prost

Developing tissues often maintain mechanical coherence while continuously remodeling through cellular processes such as cell divisions and rearrangements. In this way, they are an example of amorphous solids. In passive amorphous solids,…

Soft Condensed Matter · Physics 2026-05-13 Ali Tahaei , Ahandeep Manna , Marko Popović

The mortality rate of many complex multicellular organisms increase with age, which suggests that net aging damage is accumulative, despite remodeling processes. But how exactly do little mishaps in the cellular level accumulate and spread…

Tissues and Organs · Quantitative Biology 2017-12-12 Daniel Suma , Aylin Acun , Pinar Zorlutuna , Dervis Can Vural

We study numerically a Ginzburg-Landau type equation for micelles in two dimensions. The domain size and the interface length of a cellular structure are controlled by two feedback terms. The deformation and the successive splitting of the…

Soft Condensed Matter · Physics 2009-07-01 Hidetsugu Sakaguchi

We consider the dynamics and kinetic roughening of wetting fronts in the case of forced wetting driven by a constant mass flux into a 2D disordered medium. We employ a coarse-grained phase field model with local conservation of density,…

Disordered Systems and Neural Networks · Physics 2009-11-11 T. Laurila , C. Tong , I. Huopaniemi , S. Majaniemi , T. Ala-Nissila

The organization of live cells into tissues and their subsequent biological function involves inter-cell mechanical interactions, which are mediated by their elastic environment. To model this interaction, we consider cells as spherical…

Soft Condensed Matter · Physics 2024-02-20 Roman Golkov , Yair Shokef

The dynamics of phase-separated interfaces shape the behavior of both passive and active condensates. While surface tension in equilibrium systems minimizes interface length, non-equilibrium fluxes can destabilize flat or constantly curved…

Soft Condensed Matter · Physics 2025-05-27 Florian Raßhofer , Simon Bauer , Alexander Ziepke , Ivan Maryshev , Erwin Frey

We study a generic model for the polarisation and motility of self-propelled soft objects, biological cells or biomimetic systems, interacting with a viscous substrate. The active forces generated by the cell on the substrate are modelled…

Soft Condensed Matter · Physics 2015-06-23 M. Leoni , P. Sens

In contexts ranging from embryonic development to bacterial ecology, cell populations migrate chemotactically along self-generated chemical gradients, often forming a propagating front. Here, we theoretically show that the stability of such…

Biological Physics · Physics 2022-06-07 Ricard Alert , Alejandro Martínez-Calvo , Sujit S. Datta

When a spatially localized stress is applied to a growing one-dimensional interface, the interface deforms. This deformation is described by the effective surface tension representing the stiffness of the interface. We present that the…

Statistical Mechanics · Physics 2023-05-17 Mutsumi Minoguchi , Shin-ichi Sasa

We investigate morphologies of proliferating cellular tissues using a newly developed numerical simulation model for mechanical cell division and migration in 2D. The model is applied to a bimodal mixture consisting of stiff cells with a…

Soft Condensed Matter · Physics 2021-05-26 Pranav Madhikar , Jan Åström , Björn Baumeier , Mikko Karttunen

The motility of a cell can be triggered or inhibited not only by an applied force but also by a mechanically neutral force couple. This type of loading, represented by an applied stress and commonly interpreted as either squeezing or…

Soft Condensed Matter · Physics 2018-01-24 Thibaut Putelat , Pierre Recho , Lev Truskinovsky

The mechanism by which cells measure the dimension of the organ in which they are embedded, and slow down their growth when the final size is reached, is a long-standing problem of developmental biology. The role of mechanics in this…

Biological Physics · Physics 2023-07-19 Alexander Erlich , Pierre Recho

We demonstrate that topological insulators exhibit an intrinsic interfacial instability that amplifies small interface fluctuations, resulting in chaotic behavior during interface growth. This mechanism is fundamentally different from…

Mesoscale and Nanoscale Physics · Physics 2025-12-29 Yutaro Tanaka , Akira Furusaki

We investigate the individual and collective dynamics of torque-driven particles, called microrollers, near fluid-fluid interfaces. We find that the viscosity ratio across the interface controls the speed and direction of the particles,…

Soft Condensed Matter · Physics 2023-06-19 Blaise Delmotte

Cell growth, division and death are defining features of biological tissues that contribute to morphogenesis. In hydrodynamic descriptions of cohesive tissues, their occurrence implies a non-zero rate of variation of cell density. We show…

Tissues and Organs · Quantitative Biology 2017-08-23 Shunsuke Yabunaka , Philippe Marcq

Bacterial cellulose is an important class of biomaterials which can be grown in well-controlled laboratory and industrial conditions. The cellulose structure is affected by several biological, chemical and environmental factors, including…

Biological Physics · Physics 2021-07-28 Sung-Ha Hong , Jia Yang , Mahdi Davoodianidalik , Horst Punzmann , Michael Shats , Hua Xia

The growth of a tissue, which depends on cell-cell interactions and biologically relevant process such as cell division and apoptosis, is regulated by a mechanical feedback mechanism. We account for these effects in a minimal…

Soft Condensed Matter · Physics 2022-07-06 Sumit Sinha , Xin Li , Rajsekhar Das , D. Thirumalai

Based on a non-equilibrium mechanism for spatial pattern formation we study how position information can be controlled by locally coupled discrete dynamical networks, similar to gene regulation networks of cells in a developing…

Molecular Networks · Quantitative Biology 2009-08-26 Thimo Rohlf , Stefan Bornholdt

We analyze from a far field the evolution of an interface that separates ideal incompressible fluids of different densities and has an interfacial mass flux. We develop and apply the general matrix method to rigorously solve the boundary…