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Bayesian adaptive clinical trials offer a flexible and efficient alternative to traditional fixed-design trials, but their implementation is often hindered by the complexity of Bayesian computations and the need for advanced statistical…

Applications · Statistics 2025-07-04 Krishna Padmanabhan , Danny Baker

Dynamic Causal Modeling (DCM) is a Bayesian framework for inferring on hidden (latent) neuronal states, based on measurements of brain activity. Since its introduction in 2003 for functional magnetic resonance imaging data, DCM has been…

Quantitative Methods · Quantitative Biology 2021-04-08 Inês Pereira , Stefan Frässle , Jakob Heinzle , Dario Schöbi , Cao Tri Do , Moritz Gruber , Klaas E. Stephan

In this work, we propose a denoising diffusion generative model (DDGM) trained with healthy electrocardiogram (ECG) data that focuses on ECG morphology and inter-lead dependence. Our results show that this innovative generative model can…

Signal Processing · Electrical Eng. & Systems 2024-01-12 Gabriel V. Cardoso , Lisa Bedin , Josselin Duchateau , Rémi Dubois , Eric Moulines

Linear mixed models are able to handle an extraordinary range of complications in regression-type analyses. Their most common use is to account for within-subject correlation in longitudinal data analysis. They are also the standard vehicle…

Statistics Theory · Mathematics 2007-06-13 Y. Zhao , J. Staudenmayer , B. A. Coull , M. P. Wand

In differentiable neural architecture search (NAS) algorithms like DARTS, the training set used to update model weight and the validation set used to update model architectures are sampled from the same data distribution. Thus, the uncommon…

Machine Learning · Computer Science 2021-12-02 Ruisi Zhang , Youwei Liang , Sai Ashish Somayajula , Pengtao Xie

Latent Gaussian models (LGMs) are perhaps the most commonly used class of models in statistical applications. Nevertheless, in areas ranging from longitudinal studies in biostatistics to geostatistics, it is easy to find datasets that…

Methodology · Statistics 2022-11-22 Rafael Cabral , David Bolin , Håvard Rue

Joint models (JMs) for longitudinal and time-to-event data are an important class of biostatistical models in health and medical research. When the study population consists of heterogeneous subgroups, the standard JM may be inadequate and…

Methodology · Statistics 2024-10-31 Sida Chen , Danilo Alvares , Marco Palma , Jessica K. Barrett

Cognitive diagnostics in the Web-based Intelligent Education System (WIES) aims to assess students' mastery of knowledge concepts from heterogeneous, noisy interactions. Recent work has tried to utilize Large Language Models (LLMs) for…

Artificial Intelligence · Computer Science 2025-10-08 Guixian Zhang , Guan Yuan , Ziqi Xu , Yanmei Zhang , Jing Ren , Zhenyun Deng , Debo Cheng

This paper studies large-scale dynamical networks where the current state of the system is a linear transformation of the previous state, contaminated by a multivariate Gaussian noise. Examples include stock markets, human brains and gene…

Computation · Statistics 2015-06-23 Yiyuan She , Yuejia He , Shijie Li , Dapeng Wu

Digital learning platforms are increasingly used to support reading development while generating rich log files and item-level textual content. Using these data, this study proposes a dynamic cognitive diagnostic modelling (CDM) framework…

Methodology · Statistics 2026-04-09 Yawen Ma , Sahoko Ishida , Kate Cain , Gabriel Wallin

Neural population activity exhibits complex, nonlinear dynamics, varying in time, over trials, and across experimental conditions. Here, we develop Conditionally Linear Dynamical System (CLDS) models as a general-purpose method to…

Neurons and Cognition · Quantitative Biology 2025-10-31 Victor Geadah , Amin Nejatbakhsh , David Lipshutz , Jonathan W. Pillow , Alex H. Williams

Functional connectivity analysis is an important tool for characterizing interactions among brain regions, particularly in studies of neurodegenerative disorders such as Alzheimer's disease (AD). Gaussian graphical models (GGMs) provide a…

Methodology · Statistics 2026-04-14 Panpan Zhang , Shiying Xiao , W. Hudson Robb , Dandan Liu , Angela L. Jefferson , Jun Yan

In this technical note, we address an unresolved challenge in neuroimaging statistics: how to determine which of several datasets is the best for inferring neuronal responses. Comparisons of this kind are important for experimenters when…

The Drift-Diffusion Model (DDM) is widely used in neuropsychological studies to understand the decision process by incorporating both reaction times and subjects' responses. Various models have been developed to estimate DDM parameters,…

Applications · Statistics 2025-07-03 Zekai Jin , Yaakov Stern , Seonjoo Lee

We consider the problem of including additional knowledge in estimating sparse Gaussian graphical models (sGGMs) from aggregated samples, arising often in bioinformatics and neuroimaging applications. Previous joint sGGM estimators either…

Machine Learning · Computer Science 2019-04-18 Beilun Wang , Arshdeep Sekhon , Yanjun Qi

Bayesian networks are widely used to learn and reason about the dependence structure of discrete variables. However, they are only capable of formally encoding symmetric conditional independence, which in practice is often too strict to…

Artificial Intelligence · Computer Science 2023-01-03 Manuele Leonelli , Gherardo Varando

This article describes blavaan, an R package for estimating Bayesian structural equation models (SEMs) via JAGS and for summarizing the results. It also describes a novel parameter expansion approach for estimating specific types of models…

Computation · Statistics 2018-06-19 Edgar C. Merkle , Yves Rosseel

The question of how to combine experimental results that `appear' to be in mutual disagreement, treated in detail years ago in a previous paper, is revisited. The first novelty of the present note is the explicit use of graphical models, in…

Data Analysis, Statistics and Probability · Physics 2020-01-14 Giulio D'Agostini

Discrete choice models (DCMs) are used to analyze individual decision-making in contexts such as transportation choices, political elections, and consumer preferences. DCMs play a central role in applied econometrics by enabling inference…

Machine Learning · Statistics 2025-12-19 Daniel F. Villarraga , Ricardo A. Daziano

Bayesian methodologies prioritising accurate associations above sparsity in Gaussian graphical model (GGM) estimation remain relatively scarce in scientific literature. It is well accepted that the $\ell_2$ penalty enjoys a smaller…

Methodology · Statistics 2022-10-31 J. Smith , M. Arashi , A. Bekker