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Response-adaptive designs have been extensively studied and used in clinical trials. However, there is a lack of a comprehensive study of response-adaptive designs that include covariates, despite their importance in clinical experiments.…

Statistics Theory · Mathematics 2008-12-26 Li-Xin Zhang , Feifang Hu , Siu Hung Cheung , Wai Sum Chan

Copula modelling has in the past decade become a standard tool in many areas of applied statistics. However, a largely neglected aspect concerns the design of related experiments. Particularly the issue of whether the estimation of copula…

Methodology · Statistics 2014-06-12 Elisa Perrone , Werner G. Müller

This paper extends the design-based framework to settings with multi-way cluster dependence, and shows how multi-way clustering can be justified when clustered assignment and clustered sampling occurs on different dimensions, or when either…

Econometrics · Economics 2023-09-06 Luther Yap

The impressive performance exhibited by modern machine learning models hinges on the ability to train such models on a very large amounts of labeled data. However, since access to large volumes of labeled data is often limited or expensive,…

Machine Learning · Computer Science 2021-04-27 Neta Shoham , Haim Avron

Model-based process design and operation involves here-and-now and wait-and-see decisions. Here-and-now decisions include design variables like the size of heat exchangers or the height of distillation columns, whereas wait-and-see…

Information visualization significantly enhances human perception by graphically representing complex data sets. The variety of visualization designs makes it challenging to efficiently evaluate all possible designs catering to users'…

Methodology · Statistics 2020-04-07 Xiaoning Kang , Xiaoyu Chen , Ran Jin , Hao Wu , Xinwei Deng

As the meta-analysis of more than one diagnostic tests can impact clinical decision making and patient health, there is an increasing body of research in models and methods for meta-analysis of studies comparing multiple diagnostic tests.…

Methodology · Statistics 2021-05-11 Aristidis K. Nikoloulopoulos

The hybrid approach to experimental design aims to control frequentist operating characteristics of Bayesian decision procedures. These operating characteristics are assessed by simulating sampling distributions of posterior summaries under…

Methodology · Statistics 2026-05-04 Luke Hagar , James M. McGree

The ability to design effective experiments is crucial for obtaining data that can substantially reduce the uncertainty in the predictions made using computational models. An optimal experimental design (OED) refers to the choice of a…

Methodology · Statistics 2025-06-17 Troy Butler , John Jakeman , Michael Pilosov , Scott Walsh , Timothy Wildey

We present a review of methods for optimal experimental design (OED) for Bayesian inverse problems governed by partial differential equations with infinite-dimensional parameters. The focus is on problems where one seeks to optimize the…

Optimization and Control · Mathematics 2021-02-01 Alen Alexanderian

Over time, clinical trials have increasingly incorporated complex design and analysis elements such as interim analyses, adaptations, multiple endpoints, and sophisticated multiplicity schemes for multiple endpoints and/or treatment arms…

The first order behavior of multivariate heavy-tailed random vectors above large radial thresholds is ruled by a limit measure in a regular variation framework. For a high dimensional vector, a reasonable assumption is that the support of…

Statistics Theory · Mathematics 2019-06-27 Holger Drees , Anne Sabourin

Data series classification is an important and challenging problem in data science. Explaining the classification decisions by finding the discriminant parts of the input that led the algorithm to some decisions is a real need in many…

Machine Learning · Computer Science 2022-07-26 Paul Boniol , Mohammed Meftah , Emmanuel Remy , Themis Palpanas

The value of multiple choice questions (MCQs) in seeking large-scale, high-stakes, educational assessment is widely established. Students' responses to test items with a multiple-choice question format enable assess the extent of students'…

Physics Education · Physics 2019-06-20 P. K. Joshi , Y. Jain , R. Khunyakari , S. Basu

In current research, machine and deep learning solutions for the classification of temporal data are shifting from single-channel datasets (univariate) to problems with multiple channels of information (multivariate). The majority of these…

Machine Learning · Computer Science 2023-04-13 Leonardos Pantiskas , Kees Verstoep , Mark Hoogendoorn , Henri Bal

Utilizing covariate information has been a powerful approach to improve the efficiency and accuracy for causal inference, which support massive amount of randomized experiments run on data-driven enterprises. However, state-of-art…

Methodology · Statistics 2023-11-06 Yuhang Wu , Jinghai He , Zeyu Zheng

We consider the problem of obtaining D-optimal designs for factorial experiments with a binary response and $k$ qualitative factors each at two levels. We obtain a characterization for a design to be locally D-optimal. Based on this…

Statistics Theory · Mathematics 2015-03-19 Jie Yang , Abhyuday Mandal , Dibyen Majumdar

For multivariate regularly random vectors of dimension $d$, the dependence structure of the extremes is modeled by the so-called angular measure. When the dimension $d$ is high, estimating the angular measure is challenging because of its…

Methodology · Statistics 2025-05-29 Lucas Butsch , Vicky Fasen-Hartmann

We consider the problem of evaluating designs for a two-arm randomized experiment with an incidence (binary) outcome under a nonparametric general response model. Our two main results are that the priori pair matching design of Greevy et…

Methodology · Statistics 2022-09-02 Adam Kapelner , Abba M. Krieger , David Azriel

Many applications of machine learning methods involve an iterative protocol in which data are collected, a model is trained, and then outputs of that model are used to choose what data to consider next. For example, one data-driven approach…

Machine Learning · Computer Science 2025-04-07 Clara Fannjiang , Stephen Bates , Anastasios N. Angelopoulos , Jennifer Listgarten , Michael I. Jordan