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Objective: Dynamic cone-beam CT (CBCT) imaging is highly desired in image-guided radiation therapy to provide volumetric images with high spatial and temporal resolutions to enable applications including tumor motion tracking/prediction and…
Conventional MRI reconstruction methods treat images and coil sensitivities as discrete objects, leading to high memory demands and limited structural awareness that hamper effective regularization. These limitations hinder accurate…
Contrast agents in dynamic contrast enhanced magnetic resonance imaging allow to localize tumors and observe their contrast kinetics, which is essential for cancer characterization and respective treatment decision-making. However, contrast…
Dynamic contrast-enhanced (DCE) MRI is essential for breast cancer diagnosis and treatment. However, its reliance on contrast agents introduces safety concerns, contraindications, increased cost, and workflow complexity. To this end, we…
In vivo cardiac diffusion tensor imaging (cDTI) is a promising Magnetic Resonance Imaging (MRI) technique for evaluating the micro-structure of myocardial tissue in the living heart, providing insights into cardiac function and enabling the…
Time-resolved MR angiography (tMRA) has been widely used for dynamic contrast enhanced MRI (DCE-MRI) due to its highly accelerated acquisition. In tMRA, the periphery of the k-space data are sparsely sampled so that neighbouring frames can…
Perfusion-weighted magnetic resonance imaging (MRI) is an imaging technique that allows one to measure tissue perfusion in an organ of interest through the injection of an intravascular paramagnetic contrast agent (CA). Due to a preference…
In spite of its extensive adaptation in almost every medical diagnostic and examinatorial application, Magnetic Resonance Imaging (MRI) is still a slow imaging modality which limits its use for dynamic imaging. In recent years, Parallel…
Radiomics is an active area of research in medical image analysis, the low reproducibility of radiomics has limited its applicability to clinical practice. This issue is especially prominent when radiomic features are calculated from noisy…
Magnetic particle imaging reconstructs tracer distributions using a system matrix obtained through time-consuming, noise-prone calibration measurements. Methods for addressing imperfections in measured system matrices increasingly rely on…
Magnetic Resonance Imaging (MRI) is a crucial medical imaging technology for the screening and diagnosis of frequently occurring cancers. However image quality may suffer by long acquisition times for MRIs due to patient motion, as well as…
In this paper, we investigate image reconstruction for dynamic Computed Tomography. The motion of the target with respect to the measurement acquisition rate leads to highly resolved in time but highly undersampled in space measurements.…
Dynamic fetal heart magnetic resonance imaging (MRI) presents unique challenges due to the fast heart rate of the fetus compared to adult subjects and uncontrolled fetal motion. This requires high temporal and spatial resolutions over a…
Dynamic cone-beam computed tomography (CBCT) can capture high-spatial-resolution, time-varying images for motion monitoring, patient setup, and adaptive planning of radiotherapy. However, dynamic CBCT reconstruction is an extremely…
Image reconstruction from insufficient data is common in computed tomography (CT), e.g., image reconstruction from truncated data, limited-angle data and sparse-view data. Deep learning has achieved impressive results in this field.…
Traditional model-based image reconstruction (MBIR) methods combine forward and noise models with simple object priors. Recent application of deep learning methods for image reconstruction provides a successful data-driven approach to…
This thesis consists of original contributions in the area of digital signal processing. The reconstruction of signals sparse (highly concentrated) in various transform domains is the primary problem analyzed in the thesis. The considered…
Introduction: Quantification of dynamic contrast-enhanced (DCE)-MRI has the potential to provide valuable clinical information, but robust pharmacokinetic modeling remains a challenge for clinical adoption. Methods: A 7-layer neural network…
Dose reduction in computed tomography (CT) is essential for decreasing radiation risk in clinical applications. Iterative reconstruction is one of the most promising ways to compensate for the increased noise due to reduction of photon…
We propose a novel deformation corrected compressed sensing (DC-CS) framework to recover dynamic magnetic resonance images from undersampled measurements. We introduce a generalized formulation that is capable of handling a wide class of…