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Machine learning (ML) algorithms are showing a growing trend in helping the scientific communities across different disciplines and institutions to address large and diverse data problems. However, many available ML tools are…

Autonomous scientific research, capable of independently conducting complex experiments and serving non-specialists, represents a long-held aspiration. Achieving it requires a fundamental paradigm shift driven by artificial intelligence…

Artificial Intelligence · Computer Science 2025-07-04 Mingyu Wu , Zhaoguo Wang , Jiabin Wang , Zhiyuan Dong , Jingkai Yang , Qingting Li , Tianyu Huang , Lei Zhao , Mingqiang Li , Fei Wang , Chunhai Fan , Haibo Chen

Genomics data is essential in biological and medical domains, and bioinformatics analysts often manually create circos plots to analyze the data and extract valuable insights. However, creating circos plots is complex, as it requires…

Human-Computer Interaction · Computer Science 2025-04-01 Mingyang Gu , Jiamin Zhu , Qipeng Wang , Fengjie Wang , Xiaolin Wen , Yong Wang , Min Zhu

Causal analysis is a crucial task in many domains, including manufacturing, social science, and medicine. However, despite recent progress, the conceptual and methodological complexity of causal methods makes them largely inaccessible to…

Artificial Intelligence · Computer Science 2026-05-27 Phi Nguyen Xuan , Nicholas Tagliapietra , Lavdim Halilaj , Kristian Kersting , Juergen Luettin

Ontology Matching (OM) plays an important role in many domains such as bioinformatics and the Semantic Web, and its research is becoming increasingly popular, especially with the application of machine learning (ML) techniques. Although the…

Artificial Intelligence · Computer Science 2023-07-25 Yuan He , Jiaoyan Chen , Hang Dong , Ernesto Jiménez-Ruiz , Ali Hadian , Ian Horrocks

Many ontologies have been developed in biology and these ontologies increasingly contain large volumes of formalized knowledge commonly expressed in the Web Ontology Language (OWL). Computational access to the knowledge contained within…

Databases · Computer Science 2015-02-02 Robert Hoehndorf , Luke Slater , Paul N. Schofield , Georgios V. Gkoutos

Biclustering is a data mining technique which searches for local patterns in numeric tabular data with main application in bioinformatics. This technique has shown promise in multiple areas, including development of biomarkers for cancer,…

Machine Learning · Computer Science 2021-05-05 Paweł Renc , Patryk Orzechowski , Aleksander Byrski , Jarosław Wąs , Jason H. Moore

In the past few decades, the life sciences have experienced an unprecedented accumulation of data, ranging from genomic sequences and proteomic profiles to heavy-content imaging, clinical assays, and commercial biological products for…

Databases · Computer Science 2025-09-22 Rosalia Moreddu

Database-search algorithms, that deduce peptides from Mass Spectrometry (MS) data, have tried to improve the computational efficiency to accomplish larger, and more complex systems biology studies. Existing serial, and high-performance…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-02-08 Muhammad Haseeb , Fahad Saeed

Epistemic AI accelerates biomedical discovery by finding hidden connections in the network of biomedical knowledge. The Epistemic AI web-based software platform embodies the concept of knowledge mapping, an interactive process that relies…

Artificial Intelligence · Computer Science 2022-04-04 Da Chen Emily Koo , Heather Bowling , Kenneth Ashworth , David J. Heeger , Stefano Pacifico

Motivation: The rapid growth of biological data has intensified the need for transparent, reproducible, and well-documented computational workflows. The ability to clearly connect the steps of a workflow in the code with their description…

Computation and Language · Computer Science 2026-03-10 Clémence Sebe , Olivier Ferret , Aurélie Névéol , Mahdi Esmailoghli , Ulf Leser , Sarah Cohen-Boulakia

We view Digital Ecosystems to be the digital counterparts of biological ecosystems. Here, we are concerned with the creation of these Digital Ecosystems, exploiting the self-organising properties of biological ecosystems to evolve…

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The human-associated microbiome is closely tied to human health and is of substantial clinical interest. Metagenomics-based tools are emerging for clinical diagnostics, tracking the spread of diseases, and surveillance of potential…

Research in the Life Sciences depends on the integration of large, distributed and heterogeneous data sources and web services. The discovery of which of these resources are the most appropriate to solve a given task is a complex research…

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Combining clinical and omics data can improve both daily clinical routines and research to gain more insights into complex medical procedures. We present the results of our first phase in a multi-year collaboration with analysts and…

Human-Computer Interaction · Computer Science 2023-09-25 Markus Höhn , Hendrik Lücke-Tieke , Jan Burmeister , Jörn Kohlhammer

In the past decade, enormous progress has been made in advancing the state-of-the-art in bioimage analysis - a young computational field that works in close collaboration with the life sciences on the quantitative analysis of scientific…

Other Quantitative Biology · Quantitative Biology 2023-07-11 Joran Deschamps , Damian Dalle Nogare , Florian Jug

Molecular biology knowledge can be systematically represented in a computer-readable form as a comprehensive map of molecular interactions. There exist a number of maps of molecular interactions containing detailed description of various…

Molecular Networks · Quantitative Biology 2015-02-03 Inna Kuperstein , David PA Cohen , Stuart Pook , Laurence Calzone , Emmanuel Barillot , Andrei Zinovyev

Social multimedia users are increasingly sharing all kinds of data about the world. They do this for their own reasons, not to provide data for field studies-but the trend presents a great opportunity for scientists. The Yahoo Flickr…

With the rapid development of Large Language Models (LLMs), AI agents have demonstrated increasing proficiency in scientific tasks, ranging from hypothesis generation and experimental design to manuscript writing. Such agent systems are…

Bioinformatics is a new discipline that addresses the need to manage and interpret the data that in the past decade was massively generated by genomic research. This discipline represents the convergence of genomics, biotechnology and…

Computational Engineering, Finance, and Science · Computer Science 2009-11-24 Sabu M. Thampi