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A central challenge in topological data analysis is the interpretation of barcodes. The classical algebraic-topological approach to interpreting homology classes is to build maps to spaces whose homology carries semantics we understand and…

Algebraic Topology · Mathematics 2023-08-11 Iris H. R. Yoon , Robert Ghrist , Chad Giusti

Persistent homology has been studied to better understand the structural properties and topology features of weighted networks. It can reveal hidden layers of information about the higher-order structures formed by non-pairwise interactions…

Combinatorics · Mathematics 2025-06-25 Udit Raj , Slobodan Maletić , Sudeepto Bhattacharya

Hypergraph data appear and are hidden in many places in the modern age. They are data structure that can be used to model many real data examples since their structures contain information about higher order relations among data points. One…

Social and Information Networks · Computer Science 2020-10-02 Dong Quan Ngoc Nguyen , Lin Xing , Lizhen Lin

Topological Data Analysis (TDA), a relatively new field of data analysis, has proved very useful in a variety of applications. The main persistence tool from TDA is persistent homology in which data structure is examined at many scales.…

Algebraic Topology · Mathematics 2021-09-21 Megan Johnson , Jae-Hun Jung

Persistent homology is a popular and powerful tool for capturing topological features of data. Advances in algorithms for computing persistent homology have reduced the computation time drastically -- as long as the algorithm does not…

Computational Geometry · Computer Science 2013-10-03 Ulrich Bauer , Michael Kerber , Jan Reininghaus

Persistent homology is a multiscale method for analyzing the shape of sets and functions from point cloud data arising from an unknown distribution supported on those sets. When the size of the sample is large, direct computation of the…

Persistent homology is a popular technique in topological data analysis that tracks the lifespans of homological features in a nested sequence of spaces. This data is typically presented in a multi-set called a persistence diagram or a…

Algebraic Topology · Mathematics 2025-11-26 Deni Salja

The statistical mechanical approach to complex networks is the dominant paradigm in describing natural and societal complex systems. The study of network properties, and their implications on dynamical processes, mostly focus on locally…

Statistical Mechanics · Physics 2013-06-27 Giovanni Petri , Martina Scolamiero , Irene Donato , Francesco Vaccarino

Topological data analysis is becoming increasingly relevant to support the analysis of unstructured data sets. A common assumption in data analysis is that the data set is a sample---not necessarily a uniform one---of some high-dimensional…

Algebraic Topology · Mathematics 2021-01-20 Bastian Rieck , Markus Banagl , Filip Sadlo , Heike Leitte

The persistent Betti numbers are used in topological data analysis to infer the scales at which topological features appear and disappear in the filtration of a topological space. Most commonly by means of the corresponding barcode or…

Statistics Theory · Mathematics 2021-09-14 Magnus Bakke Botnan , Christian Hirsch

Spatial transcriptomics studies are becoming increasingly large and commonplace, necessitating simultaneous analysis of a large number of spatially resolved variables. Correspondingly, a diverse range of methodologies have been proposed to…

Quantitative Methods · Quantitative Biology 2025-09-09 James Boyle , Gregory Hamm , Eleanor Williams , Robin JG Hartman , Magnus Soderburg , Ian Henry , Michael Casey

Understanding the structure of high-dimensional data is fundamental to neuroscience and other data-intensive scientific fields. While persistent homology effectively identifies basic topological features such as "holes," it lacks the…

Algebraic Topology · Mathematics 2025-07-16 Ekaterina S. Ivshina , Galit Anikeeva , Ling Zhou

Persistent homology provides information about the lifetime of homology classes along a filtration of cell complexes. Persistence barcode is a graphical representation of such information. A filtration might be determined by time in a set…

Computer Vision and Pattern Recognition · Computer Science 2018-01-04 Rocio Gonzalez-Diaz , Maria-Jose Jimenez , Belen Medrano

Protein fold classification is a classic problem in structural biology and bioinformatics. We approach this problem using persistent homology. In particular, we use alpha shape filtrations to compare a topological representation of the data…

Biomolecules · Quantitative Biology 2021-08-23 W. Hamilton , J. E. Borgert , T. Hamelryck , J. S. Marron

The Persistent Homology Transform (PHT) was introduced in the field of Topological Data Analysis about 10 years ago, and has since been proven to be a very powerful descriptor of Euclidean shapes. The PHT consists of scanning a shape from…

Algebraic Topology · Mathematics 2024-12-25 Adam Onus , Nina Otter , Renata Turkes

We present a machine learning approach that leverages persistent homology to classify bacterial flagellar motors into two functional states: rotated and stalled. By embedding protein structural data into a topological framework, we extract…

Biomolecules · Quantitative Biology 2025-12-19 Zakaria Lamine , Abdelatif Hafid , Mohamed Rahouti

Techniques from computational topology, in particular persistent homology, are becoming increasingly relevant for data analysis. Their stable metrics permit the use of many distance-based data analysis methods, such as multidimensional…

Algebraic Topology · Mathematics 2021-01-20 Bastian Rieck , Filip Sadlo , Heike Leitte

Persistent homology is an important methodology in topological data analysis which adapts theory from algebraic topology to data settings. Computing persistent homology produces persistence diagrams, which have been successfully used in…

Machine Learning · Statistics 2026-01-13 Yueqi Cao , Anthea Monod

Persistent homology is a popular and useful tool for analysing finite metric spaces, revealing features that can be used to distinguish sets of unlabeled points and as input into machine learning pipelines. The famous stability theorem of…

Computational Geometry · Computer Science 2024-05-10 Philip Smith , Vitaliy Kurlin

Artificial intelligence-assisted drug design is revolutionizing the pharmaceutical industry. Effective molecular features are crucial for accurate machine learning predictions, and advanced mathematics plays a key role in designing these…

Biomolecules · Quantitative Biology 2024-08-27 Hongsong Feng , Li Shen , Jian Liu , Guo-Wei Wei