Related papers: SETI in vivo: testing the we-are-them hypothesis

Would another origin of life resemble Earth's biochemical use of amino acids? Here we review current knowledge at three levels: 1) Could other classes of chemical structure serve as building blocks for biopolymer structure and catalysis?…

The search for extraterrestrial (alien) life is one of the greatest scientific quests yet raises fundamental questions about just what we should be looking for and how. We approach alien hunting from the perspective of an experimenter…

The synthesis problem asks to construct a reactive finite-state system from an $\omega$-regular specification. Initial specifications are often unrealizable, which means that there is no system that implements the specification. A common…

Here we review how environmental context can be used to interpret whether O2 is a biosignature in extrasolar planetary observations. This paper builds on the overview of current biosignature research discussed in Schwieterman et al. (2017),…

This study introduces a novel theoretical framework, the Stacked Autoencoder Evolution Hypothesis, which proposes that biological evolutionary systems operate through multi-layered self-encoding and decoding processes, analogous to stacked…

Despite advances in clinical genetic testing, including the introduction of exome sequencing (ES), more than 50% of individuals with a suspected Mendelian condition lack a precise molecular diagnosis. Clinical evaluation is increasingly…

One primary reason for the formulation of the term Earth-like planet and the search for such planets in the galaxy is because life has arisen in such a world. Thus, this search seems justifiable as it is known here what one is looking for.…

To render a sequence testable, namely capable of identifying and detecting errors, it is necessary to apply a transformation that increases its length by introducing statistical dependence among symbols, as commonly exemplified by the…

Evolution is the theory that plants and animals today have come from kinds that have existed in the past. Scientists such as Charles Darwin and Alfred Wallace dedicate their life to observe how species interact with their environment, grow,…

In this paper we propose a new mathematical model capable of merging Darwinian Evolution, Human History and SETI into a single mathematical scheme: 1) Darwinian Evolution over the last 3.5 billion years is defined as one particular…

Sentence encoders map sentences to real valued vectors for use in downstream applications. To peek into these representations - e.g., to increase interpretability of their results - probing tasks have been designed which query them for…

Optimization of chemical systems and processes have been enhanced and enabled by the guidance of algorithms and analytical approaches. While many methods will systematically investigate how underlying variables govern a given outcome, there…

The poly-tRNA model was recently presented for the origin and evolution of genetic coding. This model has led to a rather precise description of what might have occurred at the beginning of protein synthesis in the first life form. Here, we…

Standing genetic variation provides a rich reservoir of potentially useful mutations facilitating the adaptation to novel environments. Experimental evolution studies have demonstrated that rapid and strong phenotypic responses to selection…

Determining the full complement of protein-coding genes is a key goal of genome annotation. The most powerful approach for confirming protein coding potential is the detection of cellular protein expression through peptide mass spectrometry…

We address the possibility that intelligent civilisations that destroy themselves could present signatures observable by humanity. Placing limits on the number of self-destroyed civilisations in the Milky Way has strong implications for the…

When analyzing communities of microorganisms from their sequenced DNA, an important task is taxonomic profiling: enumerating the presence and relative abundance of all organisms, or merely of all taxa, contained in the sample. This task can…

This paper highlights a methodological approach designed to enhance the search for extraterrestrial intelligence (SETI) by hypothesizing that a transmission technosignature would likely have two features: 1) be wideband in the microwave or…

The oft-repeated claim that life is written into the laws of nature are examined and criticized. Arguments are given in favour of life spreading between near-neighbour planets in rocky impact ejecta (transpermia), but against panspermia,…

Rich information on the prebiotic evolution is still stored in contemporary genomic data. The statistical mechanism at the sequence level may play a significant role in the prebiotic evolution. Based on statistical analysis of genome…