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We explain the physical basis of a model for small globular proteins with water interactions. The water is supposed to access the protein interior in an "all-or-none" manner during the unfolding of the protein chain. As a consequence of…

Condensed Matter · Physics 2009-10-31 Audun Bakk , Alex Hansen , Kim Sneppen

Transformer architectures have proven to learn useful representations for protein classification and generation tasks. However, these representations present challenges in interpretability. In this work, we demonstrate a set of methods for…

Computation and Language · Computer Science 2021-03-30 Jesse Vig , Ali Madani , Lav R. Varshney , Caiming Xiong , Richard Socher , Nazneen Fatema Rajani

We derive interface models for 3D Rayleigh-Taylor instability (RTI), making use of a novel asymptotic expansion in the non-locality of the fluid flow. These interface models are derived for the purpose of studying universal features…

Fluid Dynamics · Physics 2023-02-14 Gavin Pandya , Steve Shkoller

We propose a theoretical model for ice growth under a wind-driven supercooled water film. The thickness and surface velocity of the water layer are variable by changing the air stream velocity. For a given water supply rate, linear…

Fluid Dynamics · Physics 2015-05-27 K. Ueno , M. Farzaneh

We study numerically and theoretically the gravity-driven flow of a viscous liquid film coating the inner side of a horizontal cylindrical tube and surrounding a shear-free dynamically inert gaseous core. The liquid-gas interface is prone…

Fluid Dynamics · Physics 2022-11-22 Shahab Eghbali , Yves-Marie Ducimetiere , Edouard Boujo , Francois Gallaire

Topographical and diffuse interface reconfigurations occur with a change in the solidification rate. In this article we pursue the hypothesis that the interface configuration during solidification is determined by the rate of entropy…

Materials Science · Physics 2017-02-14 Yaw Delali Bensah , J. A. Sekhar

Water plays a fundamental role in protein stability. However, the effect of the properties of water on the behaviour of proteins is only partially understood. Several theories have been proposed to give insight into the mechanisms of cold…

Soft Condensed Matter · Physics 2021-03-25 Giancarlo Franzese , Joan Àguila Rojas , Valentino Bianco , Ivan Coluzza

The study of protein interactions has generated great interest in the food industry. Therefore, research on new supramolecular structures shows promise. Supramolecular structures of the whey proteins {\alpha}-lactalbumin and…

An accurate description of the structure and dynamics of interfacial water is essential for phospholipid membranes, since it determines their function and their interaction with other molecules. Here we consider water confined in stacked…

Soft Condensed Matter · Physics 2018-11-16 Sotiris Samatas , Carles Calero , Fausto Martelli , Giancarlo Franzese

We develop a simple correspondence between hydrophobic surface topology of globular proteins and and an effective protein-protein adhesiveness parameter of the Baxter type. We discuss within this framework analytical interpretation of the…

Soft Condensed Matter · Physics 2007-05-23 F. N. Braun

We consider the hydrodynamics of lipid bilayers containing transmembrane proteins of arbitrary shape. This biologically-motivated problem is relevant to the cell membrane, whose fluctuating dynamics play a key role in phenomena ranging from…

Soft Condensed Matter · Physics 2016-10-10 Andrew Callan-Jones , Marc Durand , Jean-Baptiste Fournier

Bacterial attachment to a fluid interface can lead to the formation of a film with physicochemical properties that evolve with time. We study the time evolution of interface (micro)mechanics for interfaces between oil and bacterial…

Soft Condensed Matter · Physics 2015-03-26 Liana Vaccari , Daniel Allan , Nima Sharifi-Mood , Aayush Singh , Robert Leheny , Kathleen Stebe

The molecular water structure at charged aqueous interfaces is shaped by interfacial electric fields, which can induce significant anisotropy in the molecular orientations extending over nanometer-scale distances. Despite great relevance,…

Chemical Physics · Physics 2025-12-03 Álvaro Diaz-Duque , Vasileios Balos , Martin Wolf , Alexander P. Fellows , Martin Thämer

First shells of hydration and bulk solvent plays a crucial role in the folding of proteins. Here, the role of water in the dynamics of proteins has been investigated using a theoretical protein-solvent model and a statistical physics…

Soft Condensed Matter · Physics 2015-05-27 Olivier Collet

Tissue growth underpins a wide array of biological and developmental processes, and numerical modeling of growing systems has been shown to be a useful tool for understanding these processes. However, the phenomena that can be captured are…

Soft Condensed Matter · Physics 2023-11-08 Andrew Killeen , Benjamin Partridge , Thibault Bertrand , Chiu Fan Lee

Recent experiments have reported lower critical solution temperature (LCST) phase behavior of aqueous solutions of proteins induced by multivalent ions, where the solution phase separates upon heating. This phenomenon is linked to complex…

Soft Condensed Matter · Physics 2021-12-21 Anil Kumar Sahoo , Frank Schreiber , Roland R. Netz , Prabal K. Maiti

The function of membrane-embedded proteins such as ion channels depends crucially on their conformation. We demonstrate how conformational changes in asymmetric membrane proteins may be inferred from measurements of their diffusion. Such…

Soft Condensed Matter · Physics 2015-11-20 Richard G. Morris , Matthew S. Turner

Effects of chain length compatibility and molecular ratio on the two-dimensional crystallization of a binary mixed surfactant system with non-identical molecular size and its consequence on retardation to water evaporation are described via…

Soft Condensed Matter · Physics 2025-03-25 Kulsuma Begum , Abhijeet Das , Dinesh O. Shah , Sanjeev Kumar

Polymer association at liquid-liquid interfaces is a promising way to spontaneously obtain soft self-healing membranes. In the case of reversible bonding between two polymers, the macromolecules are mobile everywhere within the membrane and…

Enhanced stabilisation of protein structures via the presence of inert excipients is a key mechanism adopted both by physiological systems and in biotechnological applications. While the intrinsic stability of proteins is ultimately fixed…

Biomolecules · Quantitative Biology 2023-05-10 Mattia Miotto , Nina Warner , Giancarlo Ruocco , Gian Gaetano Tartaglia , Oren A. Scherman , Edoardo Milanetti