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A cardinal feature common to embryonic development and tissue reorganization, as well as to wound healing and cancer cell invasion, is collective cellular migration. During collective migratory events the phenomena of cell jamming and…

Soft Condensed Matter · Physics 2021-12-07 Jeffrey J. Fredberg

We investigate the emergence of global alignment in colonies of dividing rod-shaped cells under confinement. Using molecular dynamics simulations and continuous modeling, we demonstrate that geometrical anisotropies in the confining…

Soft Condensed Matter · Physics 2021-01-26 Zhihong You , Daniel J. G. Pearce , Luca Giomi

Topological defects are at the root of the large-scale organization of liquid crystals. In two-dimensional active nematics, two classes of topological defects of charges $\pm 1/2$ are known to play a major role due to active stresses.…

Soft Condensed Matter · Physics 2022-04-08 Louis Brézin , Thomas Risler , Jean-François Joanny

Most cells possess the capacity to locomote. Alone or collectively, this allows them to adapt, to rearrange, and to explore their surroundings. The biophysical characterization of such motile processes, in health and disease, has so far…

Biological Physics · Physics 2021-05-05 Vincent E. Debets , Liesbeth M. C. Janssen , Cornelis Storm

Activity and renewability are distinctive features of living matter, and constitute a new class of materials that we term renewable active matter. A striking example is the cell cytoskeleton, where myosin filaments bind to the actin…

Soft Condensed Matter · Physics 2025-05-27 M. Abhishek , Ankit Dhanuka , Deb Sankar Banerjee , Madan Rao

Adiabatic invariants foliate phase space, and impart a macro-scale hierarchy by separating microscopic variables. On a macroscopic leaf, long-scale ordered structures are created while maximizing entropy. A plasma confined in a…

Plasma Physics · Physics 2014-10-14 Z. Yoshida , S. M. Mahajan

Highly-diverse ecosystems exhibit a broad distribution of population sizes and species turnover, where species at high and low abundances are exchanged over time. We show that these two features generically emerge in the fluctuating phase…

Populations and Evolution · Quantitative Biology 2024-01-09 Thibaut Arnoulx de Pirey , Guy Bunin

Fluctuation in fluorescence emission of immobilized single molecule is typically ascribed to the chromophore's intrinsic structural conformations and the influence of local environmental factors. Despite extensive research over several…

Chemical Physics · Physics 2024-08-07 Aranyak Sarkar , Vinu Namboodiri , Manoj Kumbhakar

Cell signaling, gene expression, and metabolism are affected by cell-cell heterogeneity and random changes in the environment. The effects of such fluctuations on cell signaling and gene expression have recently been studied intensively…

Biological Physics · Physics 2015-04-02 A. -K. Gustavsson , C. B. Adiels , B. Mehlig , M. Goksör

Dynamic cooperativity in monomeric enzymes is characterized in terms of a non-Michaelis-Menten kinetic behaviour. The latter is believed to be associated with mechanisms that include multiple reaction pathways due to enzymatic…

Chemical Physics · Physics 2016-09-21 Ashutosh Kumar , Sambarta Chatterjee , Mintu Nandi , Arti Dua

The spontaneous generation of electrical activity underpins a number of essential physiological processes, and is observed even in tissues where specialized pacemaker cells have not been identified. The emergence of periodic oscillations in…

Adaptation and Self-Organizing Systems · Physics 2022-02-01 Ria Ghosh , Shakti N. Menon

We study localization driven solely by interparticle interactions in moir\'e lattice systems without intrinsic disorder or externally imposed quasiperiodic potentials. We consider a one-dimensional bilayer with incommensurate lattice…

Disordered Systems and Neural Networks · Physics 2026-02-03 Yan-Hao Yang , Zhihao Xu , Lei Ying , Qizhong Zhu

While it is well established that self-propelled particles with alignment interactions can exhibit orientational order, the impact of self-replication and annihilation, which are key characteristics in cellular systems, on spatiotemporal…

Populations and Evolution · Quantitative Biology 2025-09-09 Seiya Takamura , Nen Saito

From the formation of animal flocks to the emergence of coordinate motion in bacterial swarms, at all scales populations of motile organisms display coherent collective motion. This consistent behavior strongly contrasts with the difference…

Soft Condensed Matter · Physics 2013-11-11 Antoine Bricard , Jean-Baptiste Caussin , Nicolas Desreumaux , Olivier Dauchot , Denis Bartolo

Steady state dynamics of clustering, long range order, and inelastic collapse are experimentally observed in vertically shaken granular monolayers. At large vibration amplitudes, particle correlations show only short range order like…

Soft Condensed Matter · Physics 2009-10-31 J. S. Olafsen , J. S. Urbach

During embryonic development, structures with complex geometry can emerge from planar epithelial monolayers and to study these shape transitions is of key importance for revealing the biophysical laws involved in the morphogenesis of…

Soft Condensed Matter · Physics 2023-08-29 Daria S. Roshal , Karim Azzag , Kirill K. Fedorenko , Sergei B. Rochal , Stephen Baghdiguian

Confluent cell monolayers and epithelia tissues show remarkable patterns and correlations in structural arrangements and actively-driven collective flows. We simulate these properties using multiphase field models. The models are based on…

Soft Condensed Matter · Physics 2021-12-08 Dennis Wenzel , Axel Voigt

The temporal evolution of equilibrium fluctuations for surface steps of monoatomic height is analyzed studying one-dimensional solid-on-solid models. Using Monte Carlo simulations, fluctuations due to periphery-diffusion (PD) as well as due…

Statistical Mechanics · Physics 2014-07-31 Walter Selke

We present a hydrodynamic model of spreading epithelial monolayers as polar viscous fluids, with active contractility and traction on the substrate. The combination of both active forces generate an instability that leads to nonlinear…

Soft Condensed Matter · Physics 2017-05-02 C. Blanch-Mercader , J. Casademunt

Phagocytosis is the process by which cells, which are 5 to 10 times larger than the particle size, engulf particles, holding substantial importance in various biological contexts ranging from the nutrient uptake of unicellular organisms to…

Soft Condensed Matter · Physics 2024-11-20 Partha Sarathi Mondal , Pawan Kumar Mishra , Mitali Thorat , Ananya Verma , Shradha Mishra
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