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Symbolic models are abstract descriptions of continuous systems in which symbols represent aggregates of continuous states. In the last few years there has been a growing interest in the use of symbolic models as a tool for mitigating…

Optimization and Control · Mathematics 2007-07-31 Giordano Pola , Paulo Tabuada

This work presents the use of graph learning for the prediction of multi-step experimental outcomes for applications across experimental research, including material science, chemistry, and biology. The viability of geometric learning for…

Machine Learning · Computer Science 2024-08-13 Amanda A. Volk , Robert W. Epps , Jeffrey G. Ethier , Luke A. Baldwin

We present a parameterized synthetic dataset called Moving Symbols to support the objective study of video prediction networks. Using several instantiations of the dataset in which variation is explicitly controlled, we highlight issues in…

Computer Vision and Pattern Recognition · Computer Science 2018-03-23 Ryan Szeto , Simon Stent , German Ros , Jason J. Corso

To support and guide an extensive experimental research into systems biology of signaling pathways, increasingly more mechanistic models are being developed with hopes of gaining further insight into biological processes. In order to…

Quantitative Methods · Quantitative Biology 2009-05-28 Tina Toni , Michael P. H. Stumpf

Knowledge graphs are an expressive and widely used data structure due to their ability to integrate data from different domains in a sensible and machine-readable way. Thus, they can be used to model a variety of systems such as molecules…

Neural and Evolutionary Computing · Computer Science 2023-08-28 Dominik Dold , Josep Soler Garrido , Victor Caceres Chian , Marcel Hildebrandt , Thomas Runkler

Symbolic encoding has been used in multi-operator learning as a way to embed additional information for distinct time-series data. For spatiotemporal systems described by time-dependent partial differential equations, the equation itself…

Machine Learning · Computer Science 2024-09-19 Derek Jollie , Jingmin Sun , Zecheng Zhang , Hayden Schaeffer

We propose a numerical technique for parameter inference in Markov models of biological processes. Based on time-series data of a process we estimate the kinetic rate constants by maximizing the likelihood of the data. The computation of…

Quantitative Methods · Quantitative Biology 2011-02-15 Aleksandr Andreychenko , Linar Mikeev , David Spieler , Verena Wolf

Symbolic equations are at the core of scientific discovery. The task of discovering the underlying equation from a set of input-output pairs is called symbolic regression. Traditionally, symbolic regression methods use hand-designed…

Machine Learning · Computer Science 2021-06-14 Luca Biggio , Tommaso Bendinelli , Alexander Neitz , Aurelien Lucchi , Giambattista Parascandolo

Growing interest in modelling complex systems from brains to societies to cities using networks has led to increased efforts to describe generative processes that explain those networks. Recent successes in machine learning have prompted…

Neural and Evolutionary Computing · Computer Science 2024-01-12 Govind Gandhi

Binary decision diagrams can compactly represent vast sets of states, mitigating the state space explosion problem in model checking. Probabilistic systems, however, require multi-terminal diagrams storing rational numbers. They are…

Logic in Computer Science · Computer Science 2020-01-14 Ernst Moritz Hahn , Arnd Hartmanns

We characterise the evolution of a dynamical system by combining two well-known complex systems' tools, namely, symbolic ordinal analysis and networks. From the ordinal representation of a time-series we construct a network in which every…

We propose a new class of probabilistic neural-symbolic models, that have symbolic functional programs as a latent, stochastic variable. Instantiated in the context of visual question answering, our probabilistic formulation offers two key…

Machine Learning · Computer Science 2019-07-01 Ramakrishna Vedantam , Karan Desai , Stefan Lee , Marcus Rohrbach , Dhruv Batra , Devi Parikh

Many promising approaches to symbolic regression have been presented in recent years, yet progress in the field continues to suffer from a lack of uniform, robust, and transparent benchmarking standards. In this paper, we address this…

Neural and Evolutionary Computing · Computer Science 2021-08-02 William La Cava , Patryk Orzechowski , Bogdan Burlacu , Fabrício Olivetti de França , Marco Virgolin , Ying Jin , Michael Kommenda , Jason H. Moore

Mathematical modelling allows us to concisely describe fundamental principles in biology. Analysis of models can help to both explain known phenomena, and predict the existence of new, unseen behaviours. Model analysis is often a complex…

Quantitative Methods · Quantitative Biology 2020-08-13 Mark Blyth , Ludovic Renson , Lucia Marucci

Sequences of correlated binary patterns can represent many time-series data including text, movies, and biological signals. These patterns may be described by weighted combinations of a few dominant structures that underpin specific…

Machine Learning · Statistics 2019-03-29 Jimmy Gaudreault , Arunabh Saxena , Hideaki Shimazaki

In this paper we provide a broad benchmarking of recent genetic programming approaches to symbolic regression in the context of state of the art machine learning approaches. We use a set of nearly 100 regression benchmark problems culled…

Neural and Evolutionary Computing · Computer Science 2018-06-08 Patryk Orzechowski , William La Cava , Jason H. Moore

Causal and temporal reasoning about video dynamics is a challenging problem. While neuro-symbolic models that combine symbolic reasoning with neural-based perception and prediction have shown promise, they exhibit limitations, especially in…

Artificial Intelligence · Computer Science 2025-06-13 Adam Ishay , Zhun Yang , Joohyung Lee , Ilgu Kang , Dongjae Lim

We investigate the potential of numerical algorithms to decipher the kinetic parameters involved in multi-step chemical reactions. To this end we study a dimerization kinetics of protein as a model system. We follow the dimerization…

Biological Physics · Physics 2014-12-24 Srijeeta Talukder , Shrabani Sen , Ralf Metzler , Suman K Banik , Pinaki Chaudhury

Neural-symbolic computing has now become the subject of interest of both academic and industry research laboratories. Graph Neural Networks (GNN) have been widely used in relational and symbolic domains, with widespread application of GNNs…

Artificial Intelligence · Computer Science 2021-06-15 Luis C. Lamb , Artur Garcez , Marco Gori , Marcelo Prates , Pedro Avelar , Moshe Vardi

We discuss a method to describe the qualitative dynamics of chemical reaction networks in terms of symbolic dynamics. The method, that can be applied to mass-action reaction networks with separated timescales, uses solutions of the partial…

Molecular Networks · Quantitative Biology 2022-05-17 Aurélien Desoeuvres , Peter Szmolyan , Ovidiu Radulescu