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We present a methodology for accelerating the estimation of the free energy from path integral Monte Carlo simulations by considering an intermediate artificial reference system where interactions are inexpensive to evaluate numerically.…

Describing long-ranged electrostatics using short-ranged pair potentials is appealing since the computational complexity scales linearly with the number of particles. The foundation of this approach is to mimic the long-ranged medium…

Statistical Mechanics · Physics 2020-05-13 Björn Stenqvist , Vidar Aspelin , Mikael Lund

The Poisson-Boltzmann equation offers an efficient way to study electrostatics in molecular settings. Its numerical solution with the boundary element method is widely used, as the complicated molecular surface is accurately represented by…

Numerical Analysis · Mathematics 2021-08-25 Stefan D. Search , Christopher D. Cooper , Elwin van't Wout

It can be shown that Stable Diffusion has a permutation-invariance property with respect to the rows of Contrastive Language-Image Pretraining (CLIP) embedding matrices. This inspired the novel observation that these embeddings can…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Nicholas Karris , Luke Durell , Javier Flores , Tegan Emerson

We have extended the multilevel summation (MLS) method, originally developed to evaluate long-range Coulombic interactions in molecular dynamics (MD) simulations [Skeel et al., J. Comput. Chem., 23, 673 (2002)], to handle dispersion…

Materials Science · Physics 2014-01-16 Daniel Tameling , Paul Springer , Paolo Bientinesi , Ahmed E. Ismail

Electrochemical interfaces are of fundamental importance in electrocatalysis, batteries, and metal corrosion. Finite-field methods are one of most reliable approaches for modeling electrochemical interfaces in complete cells under realistic…

Chemical Physics · Physics 2025-06-13 Chaoqiang Feng , Bin Jiang

We study in this paper the function approximation error of multivariate linear extrapolation. The sharp error bound of linear interpolation already exists in the literature. However, linear extrapolation is used far more often in…

Optimization and Control · Mathematics 2026-05-20 Liyuan Cao , Zaiwen Wen , Ya-xiang Yuan

We propose a general theory of estimating interpolation error for smooth functions in two and three dimensions. In our theory, the error of interpolation is bound in terms of the diameter of a simplex and a geometric parameter. In the…

Numerical Analysis · Mathematics 2021-06-10 Hiroki Ishizaka , Kenta Kobayashi , Takuya Tsuchiya

Multi-fidelity simulation is a widely used strategy to reduce the computational cost of many-query numerical simulation tasks such as uncertainty quantification, design space exploration, and design optimization. The reduced basis approach…

Numerical Analysis · Mathematics 2025-09-17 Murray Cutforth , Tiffany Fan , Tony Zahtila , Alireza Doostan , Eric Darve

Massively-parallel molecular dynamics simulation is applied to systems containing electrolytes, vapour-liquid interfaces, and biomolecules in contact with water-oil interfaces. Novel molecular models of alkali halide salts are presented and…

The modeling of solid-state transformations, such as polymorphic transitions and chemical reactions in molecular crystals, is vital for many applications including drug design or the development of new synthesis methods. However, a…

Chemical Physics · Physics 2025-06-17 Natalia Goncharova , Johannes Hoja

In this paper, we present an approach to enhance interpolation and approximation error estimates. Based on a previously derived first-order Taylor-like formula, we demonstrate its applicability in improving the $P_1$-interpolation error…

Numerical Analysis · Mathematics 2023-10-31 Joel Chaskalovic , Franck Assous

The need to approximate functions is ubiquitous in science, either due to empirical constraints or high computational cost of accessing the function. In high-energy physics, the precise computation of the scattering cross-section of a…

High Energy Physics - Phenomenology · Physics 2022-06-08 Ibrahim Chahrour , James D. Wells

In this paper we present an efficient algorithm for bivariate interpolation, which is based on the use of the partition of unity method for constructing a global interpolant. It is obtained by combining local radial basis function…

Numerical Analysis · Mathematics 2014-08-04 Roberto Cavoretto

Most current machine learning interatomic potentials (MLIPs) rely on short-range approximations, without explicit treatment of long-range electrostatics. To address this, we recently developed the Latent Ewald Summation (LES) method, which…

Chemical Physics · Physics 2025-07-22 Dongjin Kim , Xiaoyu Wang , Peichen Zhong , Daniel S. King , Theo Jaffrelot Inizan , Bingqing Cheng

This report details an approach to improve the accuracy and precision of free energy difference estimates using thermodynamic integration data (slope of the free energy with respect to the switching variable lambda) and its application to…

Computational Physics · Physics 2010-01-19 Conrad Shyu , F. Marty Ytreberg

Immersed boundary methods are high-order accurate computational tools used to model geometrically complex problems in computational mechanics. While traditional finite element methods require the construction of high-quality boundary-fitted…

Numerical Analysis · Mathematics 2024-02-27 Jennifer E. Fromm , Nils Wunsch , Kurt Maute , John A. Evans , Jiun-Shyan Chen

The accurate representation of geostrophic balance is an essential requirement for numerical modelling of geophysical flows. Significant effort is often put into the selection of accurate or optimal balance representation by the…

Atmospheric and Oceanic Physics · Physics 2015-05-19 James R. Maddison , Colin J. Cotter , Patrick E. Farrell

Wavefunction extrapolation greatly reduces the number of self-consistent field (SCF) iterations and thus the overall computational cost of Born-Oppenheimer molecular dynamics (BOMD) that is based on the Kohn-Sham density functional theory.…

Computational Physics · Physics 2016-07-27 Jun Fang , Xingyu Gao , Haifeng Song , Han Wang

Molecular dynamics simulations of biomolecules have been widely adopted in biomedical studies. As classical point-charge models continue to be used in routine biomolecular applications, there have been growing demands on developing…

Computational Physics · Physics 2020-10-28 Haixin Wei , Ruxi Qi , Junmei Wang , Piotr Cieplak , Yong Duan , Ray Luo